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Designing a chemical inhibitor for the AAA protein spastin using active site mutations.
Cupido T, Pisa R, Kelley ME, Kapoor TM
Nat Chem Biol. 2019 May;15(5):444-452. doi: 10.1038/s41589-019-0225-6. Epub 2019 Feb 18.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
167542HA, EGFP Spastin M87 with exon 4For doxycycline inducible mammalian expression of EGFP tagged Spastin M87 with exon 4.
167543HA, EGFP Spastin M87 with exon 4, N386CFor doxycycline inducible mammalian expression of EGFP tagged Spastin M87 with exon 4, with N386C mutation.

Antibodies from Article