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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Slabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J, Suchyta D, Sperling AS, Fink EC, Gasser JA, Wang LR, Corsello SM, Sellar RS, Jan M, Gillingham D, Scholl C, Frohling S, Golub TR, Fischer ES, Thoma NH, Ebert BL
Nature. 2020 Sep;585(7824):293-297. doi: 10.1038/s41586-020-2374-x. Epub 2020 Jun 3.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
169930CycK-GFP (1-270AA) in Cilantro (Codon optimized)Overexpression of 1-270AA CycK-GFP fusion
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169942Bison sgRNA libraryThe BISON CRISPR library targets 713 E1, E2, and E3 ubiquitin ligases, deubiquitinases, and control genes and contains 2,852 guide RNAs. It was cloned into the pXPR003.
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Recombinant Antibodies from Article