Polygenic risk impacts PDGFRA mutation penetrance in non-syndromic cleft lip and palate.
Yu Y, Alvarado R, Petty LE, Bohlender RJ, Shaw DM, Below JE, Bejar N, Ruiz OE, Tandon B, Eisenhoffer GT, Kiss DL, Huff CD, Letra A, Hecht JT
Hum Mol Genet. 2022 Jul 21;31(14):2348-2357. doi: 10.1093/hmg/ddac037. PubMed Article
Yu Y, Alvarado R, Petty LE, Bohlender RJ, Shaw DM, Below JE, Bejar N, Ruiz OE, Tandon B, Eisenhoffer GT, Kiss DL, Huff CD, Letra A, Hecht JT
Hum Mol Genet. 2022 Jul 21;31(14):2348-2357. doi: 10.1093/hmg/ddac037. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 172596 | pCEP4-myc-PDGFRA-R914W_EGFP-PEST_reporter | Mammalian fluorescent (EGFP-PEST) reporter plasmid for PDGFRA-R914W mutant signaling. |
| 172597 | pCEP4-myc-PDGFRA-K627R_EGFP-PEST_reporter | Mammalian fluorescent (EGFP-PEST) reporter plasmid for PDGFRA-K627R mutant signaling. |
| 172598 | pCEP4-myc-PDGFRA-D842V_EGFP-PEST_reporter | Mammalian fluorescent (EGFP-PEST) reporter plasmid for PDGFRA-D842V mutant signaling. |
| 172599 | pCEP4-myc-PDGFRA-D842V+R914W_EGFP-PEST_reporter | Mammalian fluorescent (EGFP-PEST) reporter plasmid for PDGFRA-D842V+R914W mutant signaling. |
| 172600 | pCEP4-myc-PDGFRA-K627R+R914W_EGFP-PEST_reporter | Mammalian fluorescent (EGFP-PEST) reporter plasmid for PDGFRA-K627R+R914W mutant signaling. |