Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity.
Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, Gregorieff A, Ahmad M, Dimaras H, Langille E, Cole SPC, Monnier PP, Lok BH, Tsao MS, Akeno N, Schramek D, Wikenheiser-Brokamp KA, Knudsen ES, Witkiewicz AK, Wrana JL, Goodrich DW, Bremner R
Cancer Cell. 2021 Jul 13. pii: S1535-6108(21)00338-X. doi: 10.1016/j.ccell.2021.06.016. PubMed Article
Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, Gregorieff A, Ahmad M, Dimaras H, Langille E, Cole SPC, Monnier PP, Lok BH, Tsao MS, Akeno N, Schramek D, Wikenheiser-Brokamp KA, Knudsen ES, Witkiewicz AK, Wrana JL, Goodrich DW, Bremner R
Cancer Cell. 2021 Jul 13. pii: S1535-6108(21)00338-X. doi: 10.1016/j.ccell.2021.06.016. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 174168 | EFSp-GFP-YAP | Lentiviral vector to constitutively express YAP under control of the EFS promoter. |
| 174169 | EFSp-GFP-YAP (S94A) | Lentiviral vector to constitutively express TEAD-binding mutant YAP under control of the EFS promoter. |
| 174170 | EFSp-GFP-YAP (5SA) | Lentiviral vector to constitutively express overactive YAP (5 LATS phosporylation sites mutated to Ala) under control of the EFS promoter. |
| 174171 | EFSp-GFP-Empty | Control lentiviral vector expressing GFP under control of the EFS promoter. |
| 174172 | PGKp-GFP-YAP | Lentiviral vector to constitutively express YAP under control of the human PGK promoter. |
| 174173 | PGKp-GFP-YAP (S94A) | Lentiviral vector to constitutively express TEAD-binding mutant YAP under control of the human PGK promoter. |
| 174174 | PGKp-GFP-YAP (5SA) | Lentiviral vector to constitutively express overactive YAP (5 LATS phosporylation sites mutated to Ala) under control of the human PGK promoter. |
| 174175 | PGKp-GFP-Empty | Control lentiviral vector expressing GFP under control of the human PGK promoter. |
| 174176 | PGKp-GFP-TAZ | Lentiviral vector to constitutively express TAZ/WWTR1 under control of the human PGK promoter. |