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Fumarate is a terminal electron acceptor in the mammalian electron transport chain.
Spinelli JB, Rosen PC, Sprenger HG, Puszynska AM, Mann JL, Roessler JM, Cangelosi AL, Henne A, Condon KJ, Zhang T, Kunchok T, Lewis CA, Chandel NS, Sabatini DM
Science. 2021 Dec 3;374(6572):1227-1237. doi: 10.1126/science.abi7495. Epub 2021 Dec 2.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
177976pCW57.1 tTA SDHAAll-in-one dox-repressible expression of cDNA
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177977pCW57.1 tTA SDHBAll-in-one dox-repressible expression of cDNA
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177978pCW57.1 tTA UQCRC2All-in-one dox-repressible expression of cDNA
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177979pmxs_COX4Mammalian expression of COX4 cDNA
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177980pLentiCRISPRv1_SDHAlentiviral vector expressing Cas9 and a sgRNA targeting SDHA
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177981pLentiCRISPRv1_SDHBlentiviral vector expressing Cas9 and a sgRNA targeting SDHB
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177982pLentiCRISPRv1_UQCRC2lentiviral vector expressing Cas9 and a sgRNA targeting UQCRC2
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177983pLentiCRISPRv1_COX4lentiviral vector expressing Cas9 and a sgRNA targeting COX4
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177984pCW57.1_AOX-FLAGAll-in-one dox-inducible expression of Alternative Oxidase
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Recombinant Antibodies from Article