Broadly neutralizing antibodies target the coronavirus fusion peptide.
Dacon C, Tucker C, Peng L, Lee CD, Lin TH, Yuan M, Cong Y, Wang L, Purser L, Williams JK, Pyo CW, Kosik I, Hu Z, Zhao M, Mohan D, Cooper AJR, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Drawbaugh D, Eaton B, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Holbrook MR, Nemazee D, Mascola JR, Wilson IA, Tan J
Science. 2022 Jul 12:eabq3773. doi: 10.1126/science.abq3773. PubMed Article
Dacon C, Tucker C, Peng L, Lee CD, Lin TH, Yuan M, Cong Y, Wang L, Purser L, Williams JK, Pyo CW, Kosik I, Hu Z, Zhao M, Mohan D, Cooper AJR, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Drawbaugh D, Eaton B, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Holbrook MR, Nemazee D, Mascola JR, Wilson IA, Tan J
Science. 2022 Jul 12:eabq3773. doi: 10.1126/science.abq3773. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 172666 | pcDNA3.3-NL63-D14 | encodes NL63 spike protein, for pseudovirus production |
| 180375 | pcDNA3.3_SARS2_omicron_BA.1 | Pseudovirus plasmid expressing SARS-CoV-2 omicron BA.1 strain spike protein |
| 183700 | pcDNA3.3_SARS2_omicron BA.2 | expressing SARS-CoV-2 BA.2 spike protein for pseudovirus production |
| 186809 | pcDNA3.3_SARS2_BA.2.12.1 | pseudovirus plasmid that expresses spike of BA.2.12.1 |
| 186810 | pcDNA3.3_SARS2_BA.4/5 | pseudovirus plasmid expressing BA.4 and BA.5 spike protein |