A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming.
Han J, LaVigne CA, Jones BT, Zhang H, Gillett F, Mendell JT
Science. 2020 Dec 18;370(6523). pii: science.abc9546. doi: 10.1126/science.abc9546. Epub 2020 Nov 12.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 254995 | LentiCRISPRv2_sgZSWIM8 | Used to knockout human ZSWIM8 by CRISPR/Cas9 |
| 254996 | LentiCRISPRv2_sgZswim8 | Used to knockout mouse Zswim8 by CRISPR/Cas9 |
| 254997 | AAVS1-CMV-V5-ZSWIM8 | Used to overexpress V5 tagged human ZSWIM8 |
| 254998 | Lenti-CMV-AGO2-K493R | Used to overexpress Human AGO2-K493R mutant |
| 254999 | Lenti-CMV-AGO2-KR25 | Used to overexpress Human AGO2-KR25 mutant |