Addgene: Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.

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Michael Cohen
Arnold et al

Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Arnold MR, Langelier MF, Gartrell J, Kirby IT, Sanderson DJ, Bejan DS, Sileikyte J, Sundalam SK, Nagarajan S, Marimuthu P, Duell AK, Shelat AA, Pascal JM, Cohen MS
Cell Chem Biol. 2022 Dec 15;29(12):1694-1708.e10. doi: 10.1016/j.chembiol.2022.11.006. Epub 2022 Dec 8. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
192260	pCMV-PARP1_D770A-mCherry	Expresses PARP1 D770A mutant in mammalian cells. Tagged with mCherry.
192261	pCMV-PARP1_R878A-mCherry	Expresses PARP1 R878A mutant in mammalian cells. Tagged with mCherry.

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