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Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies.
Hanke L, Sheward DJ, Pankow A, Vidakovics LP, Karl V, Kim C, Urgard E, Smith NL, Astorga-Wells J, Ekstrom S, Coquet JM, McInerney GM, Murrell B
Sci Adv. 2022 Mar 25;8(12):eabm0220. doi: 10.1126/sciadv.abm0220. Epub 2022 Mar 25. PubMed Article

Plasmids from Article

ID Plasmid Purpose
194589pHEN-CoV2-nanobody-G6Bacterial expression of G6 nanobody targeting the receptor binding domain (RBD) of SARS-CoV-2 spike
194590pHEN-CoV2-nanobody-E2Bacterial expression of E2 nanobody targeting the receptor binding domain (RBD) of SARS-CoV-2 spike
194591pHEN-CoV2-nanobody-C7Bacterial expression of C7 nanobody targeting the receptor binding domain (RBD) of SARS-CoV-2 spike
194592pHEN-CoV2-nanobody-F1Bacterial expression of F1 nanobody targeting the receptor binding domain (RBD) of SARS-CoV-2 spike

Antibodies from Article