High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors.
Urfer R, Tsoulfas P, O'Connell L, Hongo JA, Zhao W, Presta LG
J Biol Chem. 1998 Mar 6;273(10):5829-40. doi: 10.1074/jbc.273.10.5829. PubMed Article
Urfer R, Tsoulfas P, O'Connell L, Hongo JA, Zhao W, Presta LG
J Biol Chem. 1998 Mar 6;273(10):5829-40. doi: 10.1074/jbc.273.10.5829. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 190202 | pMEXneo-TrkC | To express the Human TrkC receptor under the Moloney mouse sarcoma virus LTR. |
| 190203 | pMEXneo-TrkB | To express the Human TrkB receptor under the Moloney mouse sarcoma virus LTR |
| 190204 | pMEXneo-TrkC-Δ6 | To express the human TrkC that has in the extracellular domain only the second IgG like domain. Still binds NT-3. |
| 190205 | pMEXneo-TrkC-TrkB-hybrid | To express a Human TrkC receptor that binds only BDNF. The second IgG like domain which is the main binding domain comes from the TrkB receptor |