Efficient prime editing in mouse brain, liver and heart with dual AAVs.
Davis JR, Banskota S, Levy JM, Newby GA, Wang X, Anzalone AV, Nelson AT, Chen PJ, Hennes AD, An M, Roh H, Randolph PB, Musunuru K, Liu DR
Nat Biotechnol. 2023 May 4. doi: 10.1038/s41587-023-01758-z. PubMed Article
Davis JR, Banskota S, Levy JM, Newby GA, Wang X, Anzalone AV, Nelson AT, Chen PJ, Hennes AD, An M, Roh H, Randolph PB, Musunuru K, Liu DR
Nat Biotechnol. 2023 May 4. doi: 10.1038/s41587-023-01758-z. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 198732 | v1em-Nterm-PE2max-U6-sgRNA | AAV genome encoding N-terminal PE2max and U6 expression cassette |
| 198733 | v1em-Cterm-PE2max-U6-pegRNA | AAV genome encoding C-terminal PE2max and U6 expression cassette |
| 198734 | v3em-Nterm-PE2max | AAV genome encoding N-terminal PE2max |
| 198735 | v3em-Cterm-PE2max-∆RNaseH-dualU6 | AAV genome encoding C-terminal PE2max and U6 expression cassettes |