Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.
Dou D, Smith EM, Evans CS, Boecker CA, Holzbaur ELF
Cell Rep. 2023 May 1;42(5):112448. doi: 10.1016/j.celrep.2023.112448. PubMed Article
Dou D, Smith EM, Evans CS, Boecker CA, Holzbaur ELF
Cell Rep. 2023 May 1;42(5):112448. doi: 10.1016/j.celrep.2023.112448. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 200083 | PGK mScarlet-LC3B | Mammalian expression of fluorescently-tagged marker for autophagic vesicles |
| 200084 | PGK EGFP-PPM1H-WT | Mammalian expression of wild-type PPM1H |
| 200427 | PGK EGFP-LC3B | Mammalian expression of fluorescently-tagged marker for autophagic vesicles |
| 200428 | PGK ARF6(Q67L)-CFP | Mammalian expression of Q67L mutation in ARF6 |
| 200429 | PGK CFP | Mammalian expression of CFP |
| 200430 | PGK 4xMito-mEmerald | Mammalian expression of fluorescently-tagged marker for mitochondria |
| 200431 | CMV mScarlet-LC3B | Mammalian expression of fluorescently-tagged marker for autophagic vesicles |
| 200432 | CMV EGFP-PPM1H-H153D | Mammalian expression of H153D mutation in PPM1H |