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Broadly Applicable Bispecific Linker Approach to Noncovalently Target Therapeutic Nanoparticles to Tumor Cells Expressing Carcinoembryonic Antigen.

Fernando A, Sparkes A, Matus EI, Patel A, Foster FS, Goertz D, Lee P, Gariepy J
ACS Pharmacol Transl Sci. 2024 Jun 3;7(6):1864-1873. doi: 10.1021/acsptsci.4c00140. eCollection 2024 Jun 14. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
174688Anti-Halobacterium GvpA scFv 2B10-1-pcDNA 3.4 TOPOPlasmid for recombinant expression in mammalian cells of an anti-Halobacterium salinarum GvpA single chain variable fragment derived from monoclonal antibody 2B10-1
223553MFE23-ZZMFE23-ZZ, a bispecific adaptor molecule, was created by fusing a scFv, termed MFE23, recognizing carcinoembryonic antigen to protein ZZ, which binds to the Fc fragment of IgG.
223555GvpA-CaMFull length gas vesicle coat protein A derived from H. salinarum (GvpA) fused to calmodulin.

Antibodies from Article