Structure-guided discovery and engineering of miniature CRISPR-Cas12m for epigenome editing.
Yu T, Ji M, Yu D, Guan Z, Zhu R, Jiang Y, Yang Z, Qiu L, Zhang Z, Mu J, Mao F, Xiang K, Bai L, Li K
Nat Struct Mol Biol. 2026 Sep 16. doi: 10.1038/s41594-026-01890-9.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 244459 | Lenti-hU6-xCas12m sgRNA(BsmbI) | The PmCas12m/xCas12m sgRNA cloning backbone |
| 244460 | Lenti-xCas12m-VPR-P2A-mScarlet | Expression of xCas12m-VPR-mScarlet in human cells |
| 244461 | Lenti-xCas12m-KRAB-MeCP2-P2A-mScarlet | Expression of xCas12m-KRAB-MeCP2-mScarlet in human cells |
| 244462 | Lenti-xCas12m-CRISPRoff-P2A-mScarlet | Expression of xCas12m-CRISPRoff-mScarlet in human cells |