Cell type-selective AADC expression reduces motor deficits and dyskinesia in Parkinson’s disease mouse models
Chowdhury A, Fraser A, Departee M, Taskin N, Quinlan MA, Mich JK, Omstead V, Lerma N, Opitz-Araya X, Hughes AC, Kussick E, Martinez R, Reding M, Liang E, Shulga L, Rette D, Huang C, Casian B, Leibly M, Helback O, Barcelli T, Wood T, Uribe N, Bacon C, Bowlus J, Newman D, Kutsal R, Khem S, Donadio N, Yao S, Ronellenfitch K, Wright V, Gudsnuk K, Horwitz GD, Levi BP, Lein ES, Ting JT, Daigle TL
bioRxiv 2026.01.20.700641
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 246876 | AiP13663 - pAAV-AiE0450h-minBG-DDC(HBB3)-3xHA-WPRE3-bGHpA (Alias: CN3663) | Designed to drive AAV-mediated DDC-HA expression in striatal MSNs |
| 246877 | AiP16328 - pAAV-CMV-DDC(HBB3)-3xHA-WPRE3-bGHpA (Alias: HCT104) | Designed to drive AAV-mediated DDC-HA expression ubiquitously |
| 246878 | AiP13912 - pAAV-AiE0743m_3xCore2-minBG-DDC(HBB3)-3xHA-WPRE3-bGHpA (Alias: CN3912) | Designed to drive AAV-mediated DDC-HA expression in striatal cholinergic neurons |
| 246879 | AiP13742 - pAAV-AiE0888m-minBG-DDC(HBB3)-3xHA-WPRE3-bGHpA (Alias: CN3742) | Designed to drive AAV-mediated DDC-HA expression in midbrain dopaminergic neurons |
| 246880 | AiP15007 - pAAV-AiE0387m_3xCore1-minBG-DDC(HBB3)-3xHA-WPRE3-bGHpolyA (Alias: CN5007) | Designed to drive AAV-mediated DDC-HA expression in astrocytes |
| 246881 | AiP16390 - pAAV-AiE0450h-minBG-DDC-3xHA-WPRE3-bGHpA (Alias: HCT102) | Designed to drive AAV-mediated DDC-HA expression in striatal MSNs in absence of intron |
| 246882 | AiP16391 - pAAV-AiE0450h-minBG-DDC(GENSAT)-3xHA-WPRE3-bGHpA (Alias: HCT120) | Designed to drive AAV-mediated DDC-HA expression in striatal MSNs in presence of GENSAT intron |
| 246883 | AiP16392 - pAAV-AiE0450h-minBG-DDC(SV40)-3xHA-WPRE3-bGHpA (Alias: HCT121) | Designed to drive AAV-mediated DDC-HA expression in striatal MSNs in presence of SV40 intron |