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Immune evasive DNA donors and recombinases license kilobase-scale writing.

Tou CJ, Xie K, Ferreira da Silva J, Kalailingam P, Amar-Lewis E, Rufino-Ramos D, Sawyer W, Eller ML, Starzyk J, Majumdar I, Wang J, Lee D, Yang S, Meis RJ, Dahl GA, Li J, Shan R, Artzi N, Musolino PL, Wu H, Kleinstiver BP
Nature. 2026 Mar 11. doi: 10.1038/s41586-026-10241-z. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
248208pCMV-bpNLS-Bxb1 (EMK569)Bxb1 recombinase with N-terminal bpNLS, expressed from a CMV promoter.
248209pCMV-bpNLS-eeBxb1 (CJT555)eeBxb1 recombinase with N-terminal bpNLS, expressed from a CMV promoter.
248210pCMV-SV40NLS-Stab-exin21-Bxb1(A315R)-Stab (CJT604)SV40 NLS-, stabilon-, and exin21-tagged Bxb1 (A315R) recombinase, expressed from a CMV promoter.
248211pCMV-bpNLS-Stab-exin21-Bxb1(A315R)-Stab (CJT605)bpNLS-, stabilon-, and exin21-tagged Bxb1 (A315R) recombinase, expressed from a CMV promoter.

Antibodies from Article