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Nanobodies against the S2 region of the spike protein potently neutralize SARS-CoV-2 viruses and show resistance to viral immune escape

Clarke JD, Jones L, Buckle I, Sharma P, Park E, Kipar A, Kirby A, Mega D, Ramadurai S, Karmakar A, Cornish K, McCaffrey L, Campaigne H, Eyssen LEA, James WS, Stewart JP, Carroll MW, Owens RJ
Sci Rep (2026). https://doi.org/10.1038/s41598-026-67451-8 (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
251751pOPINVHH_BA.1_C2Protein expression in E. coli
251752pOPINVHH_BA.1_D3Protein expression in E. coli
251753pPINVHH_MERS-C9Protein expression in E. coli

Antibodies from Article