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Kate Galloway Lab: Engineering STRAIGHT-IN single and dual lines in the male iPS11 parental line for programmable DNA integration

Blanch-Asensio A, Gumustop DR, Wang NB, Peterman EL, Ploessl DS, Galloway KE
Stem Cell Research, 2026. In submission.

These materials are included in the STRAIGHT-IN Dual Kit.

Plasmids from Article

ID Plasmid Purpose
252223CLYBL_Bxb1-GT_CAG-EBFP_LP _TCCLYBL targeting construct with the Bxb1-GT landing pad cassette expressing EBFP
252224CLYBL_Bxb1-GA_CAG-EGFP_LP _TCCLYBL targeting construct with the Bxb1-GA landing pad cassette expressing EGFP
252225CLYBL_Bxb1-GA_CAG-mSc-ALFA_LP _TCCLYBL targeting construct with the Bxb1-GA landing pad cassette expressing mScarlet tagged with ALFA tag
252226CLYBL_CAG-TALEN-L1TALEN-expressing construct to target CLYBL (left)
252227CLYBL_CAG-TALEN-R1TALEN-expressing construct to target CLYBL (right)
252228Bxb1-GT-Donor_CBh_mCherryBxb1-GT donor plasmid for cloning DNA payloads upon NotI digest
252229Bxb1-GA-Donor_CBh_mCherryBxb1-GA donor plasmid for cloning DNA payloads upon NotI digest
252230Bxb1-GT-CAG_Donor_KanRBxb1-GT donor plasmid for cloning (trans)genes upon NotI digest, expressed under CAG promoter and upstream WPRE+polyA
252231Bxb1-GA-CAG_Donor_KanRBxb1-GA donor plasmid for cloning (trans)genes upon NotI digest, expressed under CAG promoter and upstream WPRE+polyA
252232Bxb1-GT_AIO-TetOn_Divergent_Donor_KanRBxb1-GT donor plasmid with divergent syntax for all-in-one doxycycline-inducible (trans)gene expression
252233Bxb1-GA_AIO-TetOn_Divergent_Donor_KanRBxb1-GA donor plasmid with divergent syntax for all-in-one doxycycline-inducible (trans)gene expression
252234Bxb1-GT-CAG-mGLBxb1-GT donor plasmid for constitutive mGreenLantern expression
252235Bxb1-GA-CAG-iRFP670Bxb1-GA donor plasmid for constitutive iRFP670 expression
252236Bxb1-GT-Dox-ETV2_DivBxb1-GT donor plasmid with divergent syntax for all-in-one doxycycline-inducible ETV2 expression
252237Bxb1-GA-Dox-NKX3-1_DivBxb1-GA donor plasmid with divergent syntax for all-in-one doxycycline-inducible NKX3.1 expression
252238CAG-eeBxb1_bGHeeBxb1-expressing plasmid under CAG promoter
252239pIVT-desNb_EGFP-PuroR-mRuby2Template for IVTR of destabilized antibody against EGFP or EBFP with BleoR-mRuby2 as effector
252240pIVT-desNb_EGFP-BleoR-mRuby2Template for IVTR of destabilized antibody against EGFP or EBFP with PuroR-mRuby2 as effector
252241pIVT-wtNb_ALFA-PuroR-mRuby2Template for IVTR of wt antibody against ALFA tag with PuroR-mRuby2 as effector

Antibodies from Article