Development of an ultrahigh affinity, trimeric ACE2 biologic as a universal SARS-CoV-2 antagonist.
Gonzales J, Young T, Choi H, Park M, Jewel Y, Fan C, Purohit R, Bjorkman PJ, Williams JC
Commun Biol. 2025 Oct 6;8(1):1428. doi: 10.1038/s42003-025-08819-w.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 246927 | TD3AD R273Q Myc | Expresses stabilized and enzymatically deactivated trimeric ACE2 (N51C, V343C & R273Q) with a GSG linker between trimerization domain (Collagen XVIII, E31C, V37C), with Myc tag on C-terminus. |