Protrudin acts at ER-endosome contacts to promote KIF5-mediated endosomal tubule fission.
Kleniuk J, Nadadhur AG, Rodger C, Wolfenden E, Hall IA, Cheers SR, Zlamalova E, Reid E
Neurobiol Dis. 2026 Jan;218:107231. doi: 10.1016/j.nbd.2025.107231. Epub 2025 Dec 20.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 253736 | Protrudin-WT | Control / baseline protrudin function |
| 253737 | Protrudin-FFAT | Abolish VAP binding via FFAT motif disruption |
| 253738 | Protrudin-FYVE | Abolish binding to endosomal phosphoinositides |
| 253739 | Protrudin-ΔCC | Remove kinesin-binding coiled-coil domain |