S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness.
Yurkovetskiy L, Egri S, Kurhade C, Diaz-Salinas MA, Jaimes JA, Nyalile T, Xie X, Choudhary MC, Dauphin A, Li JZ, Munro JB, Shi PY, Shen K, Luban J
bioRxiv [Preprint]. 2023 Apr 24:2023.03.30.535005. doi: 10.1101/2023.03.30.535005.
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 256956 | pDMJ2_SARS2_S_WuhanHu1 | Expresses SARS-CoV-2 spike (WuhanHu1) protein for creating pseudotyped virus |
| 256957 | pDMJ2_SARS2_S_WuhanHu1_D614G | Expresses SARS-CoV-2 spike (WuhanHu1 D614G) protein for creating pseudotyped virus |
| 256958 | pDMJ2_SARS2_S_Brigham_Day75 | Expresses SARS-CoV-2 spike (Brigham Day 75) protein for creating pseudotyped virus |
| 256959 | pDMJ2_SARS2_S_Brigham_Day75_D614 | Expresses SARS-CoV-2 spike (Brigham Day 75 D614) protein for creating pseudotyped virus |
| 256960 | pDMJ2_SARS2_S_Brigham_Day128 | Expresses SARS-CoV-2 spike (Brigham Day 128) protein for creating pseudotyped virus |
| 256961 | pDMJ2_SARS2_S_Brigham_Day128_D614 | Expresses SARS-CoV-2 spike (Brigham Day 128 D614) protein for creating pseudotyped virus |
| 256962 | pDMJ2_SARS2_S_Brigham_Day143 | Expresses SARS-CoV-2 spike (Brigham Day 143) protein for creating pseudotyped virus |
| 256964 | pDMJ2_SARS2_S_Brigham_Day146 | Expresses SARS-CoV-2 spike (Brigham Day 146) protein for creating pseudotyped virus |
| 256965 | pDMJ2_SARS2_S_Brigham_Day146_D614 | Expresses SARS-CoV-2 spike (Brigham Day 146 D614) protein for creating pseudotyped virus |
| 256966 | pDMJ2_SARS2_S_Brigham_Day152 | Expresses SARS-CoV-2 spike (Brigham Day 152) protein for creating pseudotyped virus |
| 256967 | pDMJ2_SARS2_S_Brigham_Day152_D614 | Expresses SARS-CoV-2 spike (Brigham Day 152 D614) protein for creating pseudotyped virus |
| 256968 | pDMJ2_SARS2_S_Brigham_Day146_Q183 | Expresses SARS-CoV-2 spike (Brigham Day 143 Q183) protein for creating pseudotyped virus |
| 256969 | pDMJ2_SARS2_S_Brigham_Day146_N440 | Expresses SARS-CoV-2 spike (Brigham Day 143 N440) protein for creating pseudotyped virus |
| 256970 | pDMJ2_SARS2_S_Brigham_Day146_T478 | Expresses SARS-CoV-2 spike (Brigham Day 146 T478) protein for creating pseudotyped virus |
| 256971 | pDMJ2_SARS2_S_Brigham_Day146_Q493 | Expresses SARS-CoV-2 spike (Brigham Day 146 Q493) protein for creating pseudotyped virus |
| 256972 | pDMJ2_SARS2_S_Brigham_Day146_S494 | Expresses SARS-CoV-2 spike (Brigham Day 146 S494) protein for creating pseudotyped virus |
| 256973 | pDMJ2_SARS2_S_Brigham_Day146_N501 | Expresses SARS-CoV-2 spike (Brigham Day 146 N501) protein for creating pseudotyped virus |
| 256974 | pDMJ2_SARS2_S_Brigham_Day146_I870 | Expresses SARS-CoV-2 spike (Brigham Day 146 I870) protein for creating pseudotyped virus |
| 256975 | pDMJ2_SARS2_S_Brigham_Day146_A1020 | Expresses SARS-CoV-2 spike (Brigham Day 146 A1020) protein for creating pseudotyped virus |
| 256976 | pDMJ2_SARS2_S_Alpha | Expresses SARS-CoV-2 spike (Alpha) protein for creating pseudotyped virus |
| 256977 | pDMJ2_SARS2_S_Alpha_D614 | Expresses SARS-CoV-2 spike (Alpha D614) protein for creating pseudotyped virus |
| 256978 | pDMJ2_SARS2_S_Beta | Expresses SARS-CoV-2 spike (Beta) protein for creating pseudotyped virus |
| 256979 | pDMJ2_SARS2_S_Beta _D614 | Expresses SARS-CoV-2 spike (Beta D614) protein for creating pseudotyped virus |
| 256980 | pDMJ2_SARS2_S_Gamma | Expresses SARS-CoV-2 spike (Gamma) protein for creating pseudotyped virus |
| 256981 | pDMJ2_SARS2_S_Gamma_D614 | Expresses SARS-CoV-2 spike (Gamma D614) protein for creating pseudotyped virus |
| 256983 | pDMJ2_SARS2_S_Delta_D614 | Expresses SARS-CoV-2 spike (Delta D614) protein for creating pseudotyped virus |
| 256984 | pDMJ2_SARS2_S_Epsilon | Expresses SARS-CoV-2 spike (Epsilon) protein for creating pseudotyped virus |
| 256985 | pDMJ2_SARS2_S_Epsilon_D614 | Expresses SARS-CoV-2 spike (Epsilon D614) protein for creating pseudotyped virus |
| 256986 | pDMJ2_SARS2_S_A.23 | Expresses SARS-CoV-2 spike (A.23) protein for creating pseudotyped virus |
| 256987 | pDMJ2_SARS2_S_A.23_F157 | Expresses SARS-CoV-2 spike (A.23 F157) protein for creating pseudotyped virus |
| 256988 | pDMJ2_SARS2_S_A.23_V367 | Expresses SARS-CoV-2 spike (A.23 V367) protein for creating pseudotyped virus |
| 256989 | pDMJ2_SARS2_S_A.23_Q613 | Expresses SARS-CoV-2 spike (A.23 Q613) protein for creating pseudotyped virus |
| 256990 | pDMJ2_SARS2_S_A.23.1 | Expresses SARS-CoV-2 spike (A.23.1) protein for creating pseudotyped virus |
| 256991 | pDMJ2_SARS2_S_A.23.1_R102 | Expresses SARS-CoV-2 spike (A.23.1 R102) protein for creating pseudotyped virus |
| 256992 | pDMJ2_SARS2_S_A.23.1_F157 | Expresses SARS-CoV-2 spike (A.23.1 F157) protein for creating pseudotyped virus |
| 256993 | pDMJ2_SARS2_S_A.23.1_V367 | Expresses SARS-CoV-2 spike (A.23.1 V367) protein for creating pseudotyped virus |
| 256994 | pDMJ2_SARS2_S_A.23.1_Q613 | Expresses SARS-CoV-2 spike (A.23.1 Q613) protein for creating pseudotyped virus |
| 256995 | pDMJ2_SARS2_S_A.23.1_P681 | Expresses SARS-CoV-2 spike (A.23.1 P681) protein for creating pseudotyped virus |
| 256996 | pDMJ2_SARS2_S_A.27 | Expresses SARS-CoV-2 spike (A.27) protein for creating pseudotyped virus |
| 256997 | pDMJ2_SARS2_S_A.27_L18 | Expresses SARS-CoV-2 spike (A.27 L18) protein for creating pseudotyped virus |
| 256998 | pDMJ2_SARS2_S_A.27_L452 | Expresses SARS-CoV-2 spike (A.27 L452) protein for creating pseudotyped virus |
| 256999 | pDMJ2_SARS2_S_A.27_N501 | Expresses SARS-CoV-2 spike (A.27 N501) protein for creating pseudotyped virus |
| 257000 | pDMJ2_SARS2_S_A.27_A653 | Expresses SARS-CoV-2 spike (A.27 A653) protein for creating pseudotyped virus |
| 257001 | pDMJ2_SARS2_S_A.27_H655 | Expresses SARS-CoV-2 spike (A.27 H655) protein for creating pseudotyped virus |
| 257002 | pDMJ2_SARS2_S_A.27_D796 | Expresses SARS-CoV-2 spike (A.27 D796) protein for creating pseudotyped virus |
| 257003 | pDMJ2_SARS2_S_A.27_G1219 | Expresses SARS-CoV-2 spike (A.27 G1219) protein for creating pseudotyped virus |
| 257005 | pDMJ2_SARS2_S_A.30_D80 | Expresses SARS-CoV-2 spike (A.30 D80) protein for creating pseudotyped virus |
| 257006 | pDMJ2_SARS2_S_A.30_Y144 | Expresses SARS-CoV-2 spike (A.30 Y144) protein for creating pseudotyped virus |
| 257007 | pDMJ2_SARS2_S_A.30_I210 | Expresses SARS-CoV-2 spike (A.30 I210) protein for creating pseudotyped virus |
| 257008 | pDMJ2_SARS2_S_A.30_N211 | Expresses SARS-CoV-2 spike (A.30 N211) protein for creating pseudotyped virus |
| 257009 | pDMJ2_SARS2_S_A.30_D215 | Expresses SARS-CoV-2 spike (A.30 D215) protein for creating pseudotyped virus |
| 257010 | pDMJ2_SARS2_S_A.30_R246 | Expresses SARS-CoV-2 spike (A.30 R246) protein for creating pseudotyped virus |
| 257011 | pDMJ2_SARS2_S_A.30_247SYL249 | Expresses SARS-CoV-2 spike (A.30 247SYL249) protein for creating pseudotyped virus |
| 257012 | pDMJ2_SARS2_S_A.30_W258 | Expresses SARS-CoV-2 spike (A.30 W258) protein for creating pseudotyped virus |
| 257013 | pDMJ2_SARS2_S_A.30_R346 | Expresses SARS-CoV-2 spike (A.30 R346) protein for creating pseudotyped virus |
| 257014 | pDMJ2_SARS2_S_A.30_T478 | Expresses SARS-CoV-2 spike (A.30 T478) protein for creating pseudotyped virus |
| 257015 | pDMJ2_SARS2_S_A.30_E484 | Expresses SARS-CoV-2 spike (A.30 E484) protein for creating pseudotyped virus |
| 257016 | pDMJ2_SARS2_S_A.30_H655 | Expresses SARS-CoV-2 spike (A.30 H655) protein for creating pseudotyped virus |
| 257017 | pDMJ2_SARS2_S_A.30_P681 | Expresses SARS-CoV-2 spike (A.30 P681) protein for creating pseudotyped virus |
| 257018 | pDMJ2_SARS2_S_A.30_Q957 | Expresses SARS-CoV-2 spike (A.30 Q957) protein for creating pseudotyped virus |
| 257019 | pDMJ2_SARS2_S_WuhanHu1_Q613H | Expresses SARS-CoV-2 spike (WuhanHu1 Q613H) protein for creating pseudotyped virus |
| 257020 | pDMJ2_SARS2_S_WuhanHu1_H655Y | Expresses SARS-CoV-2 spike (WuhanHu1 H655Y) protein for creating pseudotyped virus |
| 257021 | pDMJ2_SARS2_S_WuhanHu1_D614G-H655Y | Expresses SARS-CoV-2 spike (WuhanHu1 D614G-H655Y) protein for creating pseudotyped virus |
| 257022 | pDMJ2_SARS2_S_A.23_Q613-D614G | Expresses SARS-CoV-2 spike (A.23 Q613-D614G) protein for creating pseudotyped virus |
| 257023 | pDMJ2_SARS2_S_A.23_Q613-H655Y | Expresses SARS-CoV-2 spike (A.23 Q613-H655Y) protein for creating pseudotyped virus |
| 257024 | pDMJ2_SARS2_S_A.23.1_Q613-D614G | Expresses SARS-CoV-2 spike (A.23.1 Q613-D614G) protein for creating pseudotyped virus |
| 257025 | pDMJ2_SARS2_S_A.23.1_Q613-H655Y | Expresses SARS-CoV-2 spike (A.23.1 Q613-H655Y) protein for creating pseudotyped virus |
| 257026 | pDMJ2_SARS2_S_A.27_Q613H-H655 | Expresses SARS-CoV-2 spike (A.27 Q613H-H655) protein for creating pseudotyped virus |
| 257027 | pDMJ2_SARS2_S_A.27_D614G-H655 | Expresses SARS-CoV-2 spike (A.27 D514G-H655) protein for creating pseudotyped virus |
| 257028 | pDMJ2_SARS2_S_A.30_Q613H-H655 | Expresses SARS-CoV-2 spike (A.30 Q613H-H655) protein for creating pseudotyped virus |
| 257029 | pDMJ2_SARS2_S_A.30_D614G-H655 | Expresses SARS-CoV-2 spike (A.30 D614G-H655) protein for creating pseudotyped virus |
| 257030 | pDMJ2_SARS2_S_Gamma_H655 | Expresses SARS-CoV-2 spike (Gamma H655) protein for creating pseudotyped virus |
| 257031 | pDMJ2_SARS2_S_Gamma_D614-H655 | Expresses SARS-CoV-2 spike (Gamma D614-H655) protein for creating pseudotyped virus |
| 257036 | pDMJ2_SARS2_S_Omicron_BA.5 | Expresses SARS-CoV-2 spike (Omicron_BA.5) protein for creating pseudotyped virus |
| 257037 | pDMJ2_SARS2_S_Omicron_BA.5_D614 | Expresses SARS-CoV-2 spike (Omicron_BA.5 D614) protein for creating pseudotyped virus |
| 257038 | pDMJ2_SARS2_S_Omicron_BA.5_H655 | Expresses SARS-CoV-2 spike (Omicron_BA.5 H655) protein for creating pseudotyped virus |
| 257040 | pDMJ2_SARS1_S_Urbani | Expresses SARS-CoV-1 spike (Urbani) protein for creating pseudotyped virus |
| 257041 | pDMJ2_SARS1_S_Urbani_Q599H | Expresses SARS-CoV-1 spike (Urbani Q599H) protein for creating pseudotyped virus |
| 257042 | pDMJ2_SARS1_S_Urbani_D600G | Expresses SARS-CoV-1 spike (Urbani D600G) protein for creating pseudotyped virus |
| 257043 | pDMJ2_SARS1_S_Urbani_H641Y | Expresses SARS-CoV-1 spike (Urbani H641Y) protein for creating pseudotyped virus |
| 257044 | pDMJ2_SARS1_S_Urbani_D600G_H641Y | Expresses SARS-CoV-1 spike (Urbani D600G H641Y) protein for creating pseudotyped virus |
| 257045 | pDMJ2_SARS1_S_Urbani_S1S2 | Expresses SARS-CoV-1 spike (Urbani S1S2) protein for creating pseudotyped virus |
| 257046 | pDMJ2_SARS1_S_Urbani_Q599H_S1S2 | Expresses SARS-CoV-1 spike (Urbani Q599H S1S2) protein for creating pseudotyped virus |
| 257047 | pDMJ2_SARS1_S_Urbani_D600G_S1S2 | Expresses SARS-CoV-1 spike (Urbani D600G S1S2) protein for creating pseudotyped virus |
| 257048 | pDMJ2_SARS1_S_Urbani_H641Y_S1S2 | Expresses SARS-CoV-1 spike (Urbani H641Y S1S2) protein for creating pseudotyped virus |
| 257049 | pDMJ2_SARS1_S_Urbani_D600G_H641Y_S1S2 | Expresses SARS-CoV-1 spike (Urbani D600G H641Y S1S2) protein for creating pseudotyped virus |
| 257050 | pDMJ2_SARS2_S_WuhanHu1_ΔS1S2 | Expresses SARS-CoV-2 spike (WuhanHu1 ΔS1S2) protein for creating pseudotyped virus |
| 257051 | pDMJ2_SARS2_S_WuhanHu1_Q613H_ΔS1S2 | Expresses SARS-CoV-2 spike (WuhanHu1 Q613H ΔS1S2) protein for creating pseudotyped virus |
| 257052 | pDMJ2_SARS2_S_WuhanHu1_D614G_ΔS1S2 | Expresses SARS-CoV-2 spike (WuhanHu1 D614G ΔS1S2) protein for creating pseudotyped virus |
| 257091 | pDMJ2_SARS2_S_WuhanHu1_D614P | Expresses SARS-CoV-2 spike (WuhanHu1 D614P) protein for creating pseudotyped virus |
| 257092 | pDMJ2_SARS2_S_WuhanHu1_H655A | Expresses SARS-CoV-2 spike (WuhanHu1 H655A) protein for creating pseudotyped virus |
| 257093 | pDMJ2_SARS2_S_WuhanHu1_F643A | Expresses SARS-CoV-2 spike (WuhanHu1 F643A) protein for creating pseudotyped virus |
| 257095 | pDMJ2_SARS2_S_WuhanHu1_D614A | Expresses SARS-CoV-2 spike (WuhanHu1 D614A) protein for creating pseudotyped virus |
| 257096 | pDMJ2_SARS2_S_Alpha_D614A | Expresses SARS-CoV-2 spike (Alpha D614A) protein for creating pseudotyped virus |
| 257097 | pDMJ2_SARS2_S_WuhanHu1_F643C-H655C | Expresses SARS-CoV-2 spike (WuhanHu1 F643C-655C) protein for creating pseudotyped virus |
| 257099 | pDMJ2_SARS2_S_Gamma_D614A | Expresses SARS-CoV-2 spike (Gamma D614A) protein for creating pseudotyped virus |
| 257100 | pDMJ2_SARS2_S_Gamma_F643C-H655C | Expresses SARS-CoV-2 spike (Gamma F643C-H655C) protein for creating pseudotyped virus |
| 257101 | pDMJ2_SARS2_S_Gamma_D614A-F643C-H655C | Expresses SARS-CoV-2 spike (Gamma D614A-F643C-H655C) protein for creating pseudotyped virus |
| 257103 | pDMJ2_SARS1_Urbani-SARS2_WuHu1_CTD2 | Expreses SARS-CoV-1 Urbani Spike fused with SARS-CoV-2 WuhanHu-1 Spike CTD2 |
| 257104 | pDMJ2_SARS1_Urbani-SARS2_WuHu1_CTD2_D614G | Expreses SARS-CoV-1 Urbani Spike fused with SARS-CoV-2 WuhanHu-1 Spike CTD2 (D614G) |
| 257105 | pDMJ2_SARS1_Urbani-SARS2_WuHu1_CTD2_H655Y | Expreses SARS-CoV-1 Urbani Spike fused with SARS-CoV-2 WuhanHu-1 Spike CTD2 (H655Y) |
| 257107 | pDMJ2_SARS1_Urbani-SARS2_WuHu1_CTD2_D614G-H655Y | Expreses SARS-CoV-1 Urbani Spike fused with SARS-CoV-2 WuhanHu-1 Spike CTD2 (D614G-H655Y) |