Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding.
Zeng J, Cheng Z, Chen H, Wang Z, Thompson J, Crosby KT, Han H, Singhal A, Ngo W, Xia C, Rosas-Rivera D, Zhang Z, Kang MH, Mao Y, Diolaiti ME, Lee GC, Diffley JFX, Song Y, Qiu L, Krah NM, Murthy N, Jackson RN, Liu Y, Ashworth A, Doudna JA
Nature. 2026 Jun 8. doi: 10.1038/s41586-026-10738-7.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 257716 | pJZ012_EFS-Cas12a2-puro | Express SuCas12a2 in mammalian cell lines; Puromycin selection. |
| 257717 | pJZ015_EFS-Cas12a2-TagBFP | Express SuCas12a2 in mammalian cell lines; TagBFP marker. |
| 257718 | plx313-EGFR_E746_A750del | Express EGFR E746_A750 in-frame deletion mutant in mammalian cells; Geneticin/G418 selection |
| 257719 | plx313-EGFRwt | Express EGFR WT in mammalian cells; Geneticin/G418 selection |
| 257720 | plx313-tp53-e285k | Express TP53 E285K mutant in mammalian cells; Geneticin/G418 selection |
| 257721 | plx313-tp53-r175h | Express TP53 R175H mutant in mammalian cells; Geneticin/G418 selection |
| 257722 | plx313-tp53-r248q | Express TP53 R248Q mutant in mammalian cells; Geneticin/G418 selection |
| 257723 | plx313-tp53-r280k | Express TP53 R280K mutant in mammalian cells; Geneticin/G418 selection |