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Genetically targeted mTORC1 inhibitor reveals transcriptional control by nuclear mTORC1.

Zhong Y, Sahan AZ, Shao Z, Zhang QY, Zhou X, Haggett JG, Koshizuka K, Myers SA, Gutkind JS, Zhang J
Nat Chem Biol. 2026 May 14. doi: 10.1038/s41589-026-02188-z. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
260302pLenti-TetOn-Cyto-mCherry-TerminaTORLentiviral vector for inducible expression of genetically encoded mTORC1 inhibitor.
260304pLenti-TetOn-Nuc-mCherry-TerminaTORLentiviral vector for inducible expression of genetically encoded mTORC1 inhibitor targeted to the nucleus.

Antibodies from Article