An in vivo resource of age-regulated C. elegans intestinal secretory-pathway proteins highlights secreted enzymes associated with lifespan regulation.
Miklas JW, Papsdorf K, Sun ED, Tsenter A, Haseley NR, Ameglio B, Medoh UN, Richard D, McCarthy F, Artiles KL, Hims A, Levina A, Zhou OY, Elias JE, Abu-Remaileh M, Brunet A
Cell Rep. 2026 Aug 27;45(9):117902. doi: 10.1016/j.celrep.2026.117902.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 260154 | 3xHA-TurboID-ER_pJWM_014 | C. elegans intestine expressed TurboID localized to the ER ges-1p::ER-SP-3xHA-TurboID-ER-KDEL::unc-54 3’UTR |
| 260155 | C. elegans ACP7-WormScarlet_pJWM_037 | Intestine expression of ACP7/F21A3.11 tagged with WormScarlet ges-1p::F21A3.11-2xLinker-WormScarlet::SL2WormGreenLantern::unc-54 3’UTR |
| 260156 | VAPA-Scarlet_pJWM_032 | Intestine expression of VAPA/F53B6.4 tagged with WormScarlet: ges-1p::F53B6.4-2xLinker-WormScarlet::SL2WormGreenLantern::unc-54 3’UTR |
| 260157 | ACP7-3xHA_pJWM_080 | Intestine expressed ACP7/F21A3.11 with 3xHA-tags: ges-1p::F21A3.11-3xHA-tag::SL2WormScarlet::unc-54 3'UTR |
| 260158 | ACP7-7A-3xHA_pJWM_081 | Intestine expressed phosphatase inactive ACP7-7A/F21A3.11(7 point mutations) with 3xHA-tags |
| 260159 | Human ACP7_pJWM_099 | Expression of human ACP7 with 6x HIS tag: CMVp::ACP7-6xHIS::SV40 PolyA |
| 260215 | T05E12.3-Scarlet_pJWM_044 | Intestine expression of T05E12.3 tagged with WormScarlet: ges-1p::T05E12.3-2xLinker-WormScarlet::SL2WormGreenLantern::unc-54 3’UTR |
| 260216 | C02A12.4-Scarlet_pJWM_049 | Intestine expression of C02A12.4 tagged with WormScarlet: ges-1p::C02A12.4-2xLinker-WormScarlet::SL2WormGreenLantern::unc-54 3’UTR |
| 260217 | F56F10.1-Scarlet_pJWM_045 | Intestine expression of F56F10.1 tagged with WormScarlet: ges-1p::F56F10.1-2xLinker-WormScarlet::SL2WormGreenLantern::unc-54 3’UTR |
| 260218 | Secreted WormScarlet_pJWM_073 | Secreted form of WormScarlet from the intestine: ges-1:SP-WormScarlet::unc-54 3'UTR |
| 260219 | WormScarlet and WormGreenLantern_pJWM_025 | WormScarlet and WormGreenLantern expressed in the intestine: ges-1p::WormScarlet::SL2WormGreenLantern::unc-54 3'UTR |