END nucleases are antiphage defence systems targeting multiple phages with modified genomes.
Yee WX, Lee YJ, Makarova KS, Klein TA, Wirganowicz A, Gabagat AE, Liu M, Csorgo B, Koonin EV, Weigele PR, Bondy-Denomy J
Nat Microbiol. 2026 Jun 26. doi: 10.1038/s41564-026-02407-2.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 260815 | p30T ENDPaCFI | END nuclease identified from CF040 in paper; later established that it targets multiple phages with different DNA modifications in Pseudomonas aeruginosa. |
| 260816 | p30T-Ec1 | Ec1 homolog in p30T; established that it targets multiple phages with different DNA modifications in E. coli |
| 260817 | p30T-Vc | V. cholerae homolog in p30T; established that it targets multiple phages with different DNA modifications in E. coli. Seems to have a slightly wider range than Ec1. |
| 260818 | Tn7_ENDPaCFI | Plasmid to integrate END(PaCFI) into Tn7 site. |