Matrix polyamines regulate bidirectional calcium flux through MCU.
Wang Q, Balderas E, Ramos AJ, Nwafor A, McManus JS, Rai NK, Masini YB, Eberhardt DR, Rekate EC, Balynas AM, Yin X, Stewart TM, Cao E, Stary-Weinzinger A, Chaudhuri D
Structure. 2026 Jul 27:S0969-2126(26)00212-1. doi: 10.1016/j.str.2026.07.002.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 256373 | MCU-EDD-EEAA-Flag | Mutate residues in the EMRE interacting domain that may be binding polyamines (E288, E293) |
| 256374 | MCU-mGFP-EMRE-TwinStrep pTRE bidirectional | Concurrent expression of mGFP-tagged MCU and TwinStrep-tagged EMRE using tet-responsive bidirectional promoter and puro resistance in piggybac vector |