Precision A3G base editors for disease modeling and correction.
Zeng H, Liu A, Daniel TC, Golla DA, Lu Z, Serodio R, Millette BA, Lingineni A, Gilberd P, Chee K, Talloo K, Peddi A, Park SH, Bao G, Gao X
Mol Ther. 2026 Apr 1;34(4):2343-2360. doi: 10.1016/j.ymthe.2026.01.003. Epub 2026 Jan 14.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 263230 | A3G5.13P (spCas9) | Mammalian expression of the A3G5.13P (A3G5.13-PAP) engineered base editor variant using spCas9. CMV promoter. AmpR marker for E. coli. |
| 263231 | A3G5.13P-E (spCas9) | Mammalian expression of the A3G5.13P-E (A3G5.13(R320E)-PAP) engineered base editor variant using spCas9. CMV promoter. AmpR marker for E. coli. |
| 263395 | A3G5.13P (spG-Cas9) | Mammalian expression of the A3G5.13P (A3G5.13-PAP) engineered base editor variant using spG-Cas9. CMV promoter. AmpR marker for E. coli. |
| 263396 | A3G5.13P-E (SpG-Cas9) | Mammalian expression of the A3G5.13P-E (A3G5.13(R320E)-PAP) engineered base editor variant using SpG-Cas9. CMV promoter. AmpR marker for E. coli. |