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The human DeltaNp53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function.
Lin SC, Karoly ED, Taatjes DJ
Aging Cell. 2013 Oct;12(5):863-72. doi: 10.1111/acel.12108. Epub 2013 Jun 25. PubMed Article

Plasmids from Article

ID Plasmid Purpose
49242pIRES2-EGFP-p53 WTexpresses human wt p53 and EGFP in mammalian cells
49243pIRES2-mCherry-p53 deltaNexpresses human p53 deltaN and mCherry in mammalian cells
49244pIRES2-EGFP-deltaNp53:WTp53expresses human p53 deltaN linked to full length p53 with C terminal His tag and also expresses EGFP in mammalian cells
49245pIRES2-EGFP-p53 tetheredexpresses two human WT p53s tethered together and also expresses EGFP in mammalian cells

Antibodies from Article