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CRISPR-mediated direct mutation of cancer genes in the mouse liver.
Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T
Nature. 2014 Aug 6. doi: 10.1038/nature13589.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
59909pX330 PtenpX330 backbone expressing sgRNA targeting Pten to edit mouse Pten. Expresses Cas9 from CBh promoter
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59910pX330 p53pX330 backbone expressing sgRNA targeting p53 to edit mouse p53. Expresses Cas9 from CBh promoter
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59911pX330 Ctnnb1.1pX330 backbone expressing sgRNA targeting Ctnnb1 to edit mouse beta-Catenin. Expresses Cas9 from CBh promoter
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59912pX330 Ctnnb1.2pX330 backbone expressing sgRNA targeting Ctnnb1 to edit mouse beta-Catenin. Expresses Cas9 from CBh promoter
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