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We narrowed to 621 results for: Dos

Showing: 601 - 620 of 621 results

  2. dTAG - You're it!

    Type
    Blog Post
    Published
    June 21, 2018, 2:06 p.m.
    ...choice to ensure that there are no toxicities at the doses used to evaluate degradation of the FKBP12F36V-fusion... observed little to no toxicity with dTAG-13 at doses as high as 20 µM (see Figures 3 and 5 in Nabet et...See our recent papers noted below for examples of dose-responses and time-courses (Nabet et al., Erb et...

  3. CRISPR-based Genome Editing Systems For Editing in E. coli

    Type
    Blog Post
    Published
    April 13, 2021, 1:15 p.m.
    ...initial paper, we used MUCICAT to optimize the gene dosage of glucose dehydrogenase and generated a strain...higher cargo copy numbers. (D) The effect of gene dosage on N-acetylglucosamine concentration. Image from...construct a strain library with different gene dosages to facilitate swift optimization of strains. Multiple...

  4. Beyond the Blood Brain Barrier: PHP.B Enters the Central Nervous System Via the LY6A Receptor

    Type
    Blog Post
    Published
    July 23, 2019, 12:46 p.m.
    ...into the bloodstream, but requires a high vector dose and is unable to reach all regions of the CNS. PHP.B...similar transduction efficiency, but at a log lower dose than PHP.B.  A Ly6a variant is linked to PHP.B CNS...gene transfer to the rat CNS: AAV PHP. EB vector dose–response and comparison to AAV PHP. B." Gene therapy...

  5. Viral Vectors 101: Chemogenetics

    Type
    Blog Post
    Published
    July 11, 2023, 1:15 p.m.
    ...that these issues can be mitigated by using low doses and running appropriate controls (Jendryka et al...molecules (PSEMs). Higher potency means lower drug doses, which decreases the risk of off target effects....

  6. Quick Guide to All Things Lentivirus

    Type
    Blog Post
    Published
    March 21, 2017, 2:30 p.m.
    ...p24 ELISA dosing method detects the expression of viral capsid antigen p24, the FACS dosing method correlates...

  7. Cancer and the Immune System: Deciphering the Relationship

    Type
    Blog Post
    Published
    March 14, 2017, 2:30 p.m.
    ...situ before being injected back into the body in 3 doses intravenously. B cells and T cells activated ex ...leukaemia in children and young adults: a phase 1 dose-escalation trial." The Lancet 385.9967 (2015): 517...

  8. CRISPR 101 eBook...en español

    Type
    Blog Post
    Published
    Jan. 18, 2024, 2:15 p.m.
    ...Daniel Mejías Sánchez, ¡y no podríamos estar más emocionados! Después de recibir la traducción, Addgene contrató...

  13. Hot Plasmids - October 2020

    Type
    Blog Post
    Published
    Oct. 13, 2020, 1:15 p.m.
    ...-3 to proliferate. The cells cultured with a low dose of IL-3 showed reduced proliferation and had a greater...

  14. CRISPR in the Clinic

    Type
    Blog Post
    Published
    Nov. 2, 2023, 1:15 p.m.
    ...SCD in 2022 as well. Hereditary transthyretin amyloidosis (hATTR) hATTR is caused by a variety of single...

  15. Plasmids 101: Terminators and PolyA signals

    Type
    Blog Post
    Published
    March 31, 2016, 2:30 p.m.
    ...presence of the poly(A) tail targets the RNA to the degradosome, which contains enzymes that cut RNA not protected...

  18. Hot Plasmids: Summer 2024

    Type
    Blog Post
    Published
    Aug. 27, 2024, 1:15 p.m.
    ..., Cogan, J. Z., Replogle, J. M., Adriaens, C., Ramadoss, G. N., Shi, Q., Hung, K. L., Samelson, A. J.,...
Showing: 601 - 620 of 621 results