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pLKO.1 - TRC cloning vector Citations (328)

Plasmid Article: A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.
Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE Cell. 2006 Mar 24. 124(6):1283-98.
PubMed Journal

Articles Citing pLKO.1 - TRC cloning vector

Articles
Formation of Kv2.1-FAK complex as a mechanism of FAK activation, cell polarization and enhanced motility. Wei JF, Wei L, Zhou X, Lu ZY, Francis K, Hu XY, Liu Y, Xiong WC, Zhang X, Banik NL, Zheng SS, Yu SP. J Cell Physiol. 2008 Nov;217(2):544-57. doi: 10.1002/jcp.21530. PubMed
A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. Zhang X, Lian Z, Padden C, Gerstein MB, Rozowsky J, Snyder M, Gingeras TR, Kapranov P, Weissman SM, Newburger PE. Blood. 2009 Mar 12;113(11):2526-34. doi: 10.1182/blood-2008-06-162164. Epub 2009 Jan 14. PubMed
The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Chen M, Wang J, Lu J, Bond MC, Ren XR, Lyerly HK, Barak LS, Chen W. Biochemistry. 2009 Nov 3;48(43):10267-74. doi: 10.1021/bi9009677. PubMed
Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Gu B, Zhang J, Chen Q, Tao B, Wang W, Zhou Y, Chen L, Liu Y, Zhang M. Biochem Biophys Res Commun. 2010 Apr 2. 394(2):418-23. PubMed
Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. Yang JL, Tadokoro T, Keijzers G, Mattson MP, Bohr VA. J Biol Chem. 2010 Sep 3;285(36):28191-9. doi: 10.1074/jbc.M109.082883. Epub 2010 Jun 23. PubMed
Syntaxin 3 is necessary for cAMP- and cGMP-regulated exocytosis of CFTR: implications for enterotoxigenic diarrhea. Collaco A, Marathe J, Kohnke H, Kravstov D, Ameen N. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1450-60. doi: 10.1152/ajpcell.00029.2010. Epub 2010 Sep 15. PubMed
ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. Mohni KN, Livingston CM, Cortez D, Weller SK. J Virol. 2010 Dec;84(23):12152-64. doi: 10.1128/JVI.01643-10. Epub 2010 Sep 22. PubMed
In vitro genetic analysis of an erythrocyte determinant of malaria infection. Bei AK, Brugnara C, Duraisingh MT. J Infect Dis. 2010 Dec 1;202(11):1722-7. doi: 10.1086/657157. Epub 2010 Oct 19. PubMed
S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD. Cell Death Dis. 2011 Feb 10;2:e119. doi: 10.1038/cddis.2011.3. PubMed
L1 stimulation of human glioma cell motility correlates with FAK activation. Yang M, Li Y, Chilukuri K, Brady OA, Boulos MI, Kappes JC, Galileo DS. J Neurooncol. 2011 Oct;105(1):27-44. doi: 10.1007/s11060-011-0557-x. Epub 2011 Mar 4. PubMed
Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation. Hu X, Wei L, Taylor TM, Wei J, Zhou X, Wang JA, Yu SP. Am J Physiol Cell Physiol. 2011 Aug;301(2):C362-72. doi: 10.1152/ajpcell.00013.2010. Epub 2011 May 11. PubMed
Stable knockdown of MYCN by lentivirus-based RNAi inhibits human neuroblastoma cells growth in vitro and in vivo. Jiang R, Xue S, Jin Z. Biochem Biophys Res Commun. 2011 Jul 1;410(2):364-70. doi: 10.1016/j.bbrc.2011.06.020. Epub 2011 Jun 12. PubMed
Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation. Ullah Z, de Renty C, DePamphilis ML. Mol Cell Biol. 2011 Oct;31(19):4129-43. doi: 10.1128/MCB.05723-11. Epub 2011 Jul 26. PubMed
Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Yang Y, Nakagawa H, Tetreault MP, Billig J, Victor N, Goyal A, Sepulveda AR, Katz JP. Cancer Res. 2011 Oct 15;71(20):6475-84. doi: 10.1158/0008-5472.CAN-11-1702. Epub 2011 Aug 25. PubMed
DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. Mohni KN, Mastrocola AS, Bai P, Weller SK, Heinen CD. J Virol. 2011 Dec;85(23):12241-53. doi: 10.1128/JVI.05487-11. Epub 2011 Sep 28. PubMed
A Wnt/beta-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes. Ma B, van Blitterswijk CA, Karperien M. Arthritis Rheum. 2012 Aug;64(8):2589-600. doi: 10.1002/art.34425. PubMed
Sensing adenovirus infection: activation of interferon regulatory factor 3 in RAW 264.7 cells. Stein SC, Falck-Pedersen E. J Virol. 2012 Apr;86(8):4527-37. doi: 10.1128/JVI.07071-11. Epub 2012 Feb 15. PubMed
Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis. Xing L, Yao X, Williams KR, Bassell GJ. Mol Biol Cell. 2012 Apr;23(8):1500-9. doi: 10.1091/mbc.E11-10-0867. Epub 2012 Feb 22. PubMed
Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Kravtsov DV, Caputo C, Collaco A, Hoekstra N, Egan ME, Mooseker MS, Ameen NA. Traffic. 2012 Aug;13(8):1072-82. doi: 10.1111/j.1600-0854.2012.01368.x. Epub 2012 May 8. PubMed
Aire promotes the self-renewal of embryonic stem cells through Lin28. Bin G, Jiarong Z, Shihao W, Xiuli S, Cheng X, Liangbiao C, Ming Z. Stem Cells Dev. 2012 Oct 10;21(15):2878-90. doi: 10.1089/scd.2012.0097. Epub 2012 Jun 11. PubMed
Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia. DeSalvo J, Kuznetsov JN, Du J, Leclerc GM, Leclerc GJ, Lampidis TJ, Barredo JC. Mol Cancer Res. 2012 Jul;10(7):969-78. doi: 10.1158/1541-7786.MCR-12-0125. Epub 2012 Jun 12. PubMed
Cell-specific regulation of nucleic acid sensor cascades: a controlling interest in the antiviral response. Stein SC, Lam E, Falck-Pedersen E. J Virol. 2012 Dec;86(24):13303-12. doi: 10.1128/JVI.02296-12. Epub 2012 Sep 26. PubMed
Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts. Gagan J, Dey BK, Layer R, Yan Z, Dutta A. J Biol Chem. 2012 Nov 23;287(48):40360-70. doi: 10.1074/jbc.M112.378414. Epub 2012 Oct 10. PubMed
Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed
Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteins. Mohni KN, Dee AR, Smith S, Schumacher AJ, Weller SK. J Virol. 2013 Jan;87(1):531-42. doi: 10.1128/JVI.02504-12. Epub 2012 Oct 24. PubMed
Silencing alpha1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion. Buffone A Jr, Mondal N, Gupta R, McHugh KP, Lau JT, Neelamegham S. J Biol Chem. 2013 Jan 18;288(3):1620-33. doi: 10.1074/jbc.M112.400929. Epub 2012 Nov 28. PubMed
RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation. Tariq A, Garncarz W, Handl C, Balik A, Pusch O, Jantsch MF. Nucleic Acids Res. 2013 Feb 1;41(4):2581-93. doi: 10.1093/nar/gks1353. Epub 2012 Dec 28. PubMed
MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3. Liu C, Cheng H, Shi S, Cui X, Yang J, Chen L, Cen P, Cai X, Lu Y, Wu C, Yao W, Qin Y, Liu L, Long J, Xu J, Li M, Yu X. Curr Mol Med. 2013 May;13(4):467-78. PubMed
RNAi-mediated gene function analysis in skin. Beronja S, Fuchs E. Methods Mol Biol. 2013;961:351-61. doi: 10.1007/978-1-62703-227-8_23. PubMed
Up-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherin. Xu J, Zhu W, Xu W, Yao W, Zhang B, Xu Y, Ji S, Liu C, Long J, Ni Q, Yu X. Curr Mol Med. 2013 Mar;13(3):387-400. PubMed
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Chapman JR, Barral P, Vannier JB, Borel V, Steger M, Tomas-Loba A, Sartori AA, Adams IR, Batista FD, Boulton SJ. Mol Cell. 2013 Mar 7;49(5):858-71. doi: 10.1016/j.molcel.2013.01.002. Epub 2013 Jan 17. PubMed
A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing. Garncarz W, Tariq A, Handl C, Pusch O, Jantsch MF. RNA Biol. 2013 Feb;10(2):192-204. doi: 10.4161/rna.23208. Epub 2013 Jan 25. PubMed
Proteome identification of proteins interacting with histone methyltransferase SET8. Qin Y, Ouyang H, Liu J, Xie Y. Acta Biochim Biophys Sin (Shanghai). 2013 Apr;45(4):303-8. doi: 10.1093/abbs/gmt011. Epub 2013 Feb 17. PubMed
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Klauke K, Radulovic V, Broekhuis M, Weersing E, Zwart E, Olthof S, Ritsema M, Bruggeman S, Wu X, Helin K, Bystrykh L, de Haan G. Nat Cell Biol. 2013 Apr;15(4):353-62. doi: 10.1038/ncb2701. Epub 2013 Mar 17. PubMed
Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair. Xu J, Zhu W, Xu W, Cui X, Chen L, Ji S, Qin Y, Yao W, Liu L, Liu C, Long J, Li M, Yu X. Int J Oncol. 2013 Jun;42(6):2046-52. doi: 10.3892/ijo.2013.1901. Epub 2013 Apr 16. PubMed
T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor kappaB signaling. Ma B, Zhong L, van Blitterswijk CA, Post JN, Karperien M. J Biol Chem. 2013 Jun 14;288(24):17552-8. doi: 10.1074/jbc.M113.453985. Epub 2013 Apr 19. PubMed
EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation. Saha B, Home P, Ray S, Larson M, Paul A, Rajendran G, Behr B, Paul S. Mol Cell Biol. 2013 Jul;33(14):2691-705. doi: 10.1128/MCB.00069-13. Epub 2013 May 13. PubMed
Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O'Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM. PLoS One. 2013 Jun 10;8(6):e67054. doi: 10.1371/journal.pone.0067054. Print 2013. PubMed
Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. Trinh AT, Kim SH, Chang HY, Mastrocola AS, Tibbetts RS. J Biol Chem. 2013 Aug 16;288(33):23765-75. doi: 10.1074/jbc.M113.464057. Epub 2013 Jun 27. PubMed
The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. Mastrocola AS, Kim SH, Trinh AT, Rodenkirch LA, Tibbetts RS. J Biol Chem. 2013 Aug 23;288(34):24731-41. doi: 10.1074/jbc.M113.497974. Epub 2013 Jul 5. PubMed
LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program. Mao XG, Hutt-Cabezas M, Orr BA, Weingart M, Taylor I, Rajan AK, Odia Y, Kahlert U, Maciaczyk J, Nikkhah G, Eberhart CG, Raabe EH. Oncotarget. 2013 Jul;4(7):1050-64. PubMed
Specificity protein 4 functionally regulates the transcription of NMDA receptor subunits GluN1, GluN2A, and GluN2B. Priya A, Johar K, Wong-Riley MT. Biochim Biophys Acta. 2013 Dec;1833(12):2745-56. doi: 10.1016/j.bbamcr.2013.07.002. Epub 2013 Jul 18. PubMed
Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer. Itou J, Matsumoto Y, Yoshikawa K, Toi M. FEBS Lett. 2013 Sep 17;587(18):3115-21. doi: 10.1016/j.febslet.2013.07.049. Epub 2013 Aug 14. PubMed
Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca(2)(+)/calmodulin-dependent protein kinase II. Meng Z, Li T, Ma X, Wang X, Van Ness C, Gan Y, Zhou H, Tang J, Lou G, Wang Y, Wu J, Yen Y, Xu R, Huang W. Mol Cancer Ther. 2013 Oct;12(10):2067-77. doi: 10.1158/1535-7163.MCT-13-0314. Epub 2013 Aug 19. PubMed
Neuron-specific specificity protein 4 bigenomically regulates the transcription of all mitochondria- and nucleus-encoded cytochrome c oxidase subunit genes in neurons. Johar K, Priya A, Dhar S, Liu Q, Wong-Riley MT. J Neurochem. 2013 Nov;127(4):496-508. doi: 10.1111/jnc.12433. Epub 2013 Sep 30. PubMed
BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1. Yang JL, Lin YT, Chuang PC, Bohr VA, Mattson MP. Neuromolecular Med. 2014 Mar;16(1):161-74. doi: 10.1007/s12017-013-8270-x. Epub 2013 Oct 10. PubMed
Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression. de la Garza-Rodea AS, Baldwin DM, Oskouian B, Place RF, Bandhuvula P, Kumar A, Saba JD. FASEB J. 2014 Jan;28(1):506-19. doi: 10.1096/fj.13-233155. Epub 2013 Oct 24. PubMed
Regulation of Na(+)/K(+)-ATPase by neuron-specific transcription factor Sp4: implication in the tight coupling of energy production, neuronal activity and energy consumption in neurons. Johar K, Priya A, Wong-Riley MT. Eur J Neurosci. 2014 Feb;39(4):566-78. doi: 10.1111/ejn.12415. Epub 2013 Nov 12. PubMed
Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs. Donmez Cakil Y, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P. Mol Pharmacol. 2014 Mar;85(3):420-8. doi: 10.1124/mol.113.088526. Epub 2013 Dec 23. PubMed
The dual roles of geminin during trophoblast proliferation and differentiation. de Renty C, Kaneko KJ, DePamphilis ML. Dev Biol. 2014 Mar 1;387(1):49-63. doi: 10.1016/j.ydbio.2013.12.034. Epub 2014 Jan 9. PubMed
Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling. Spindler V, Dehner C, Hubner S, Waschke J. J Invest Dermatol. 2014 Jun;134(6):1655-64. doi: 10.1038/jid.2014.21. Epub 2014 Jan 17. PubMed
A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages. Alamuru NP, Behera S, Butchar JP, Tridandapani S, Kaimal Suraj S, Babu PP, Hasnain SE, Ehtesham NZ, Parsa KV. J Leukoc Biol. 2014 Jan 17. PubMed
LSD1 sustains pancreatic cancer growth via maintaining HIF1alpha-dependent glycolytic process. Qin Y, Zhu W, Xu W, Zhang B, Shi S, Ji S, Liu J, Long J, Liu C, Liu L, Xu J, Yu X. Cancer Lett. 2014 Jun 1;347(2):225-32. doi: 10.1016/j.canlet.2014.02.013. Epub 2014 Feb 18. PubMed
Specificity protein 4 (Sp4) regulates the transcription of AMPA receptor subunit GluA2 (Gria2). Priya A, Johar K, Nair B, Wong-Riley MT. Biochim Biophys Acta. 2014 Jun;1843(6):1196-206. doi: 10.1016/j.bbamcr.2014.02.008. Epub 2014 Feb 24. PubMed
Stathmin, interacting with Nf-kappaB, promotes tumor growth and predicts poor prognosis of pancreatic cancer. Lu Y, Liu C, Cheng H, Xu Y, Jiang J, Xu J, Long J, Liu L, Yu X. Curr Mol Med. 2014 Mar;14(3):328-39. PubMed
SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma. Lung HL, Man OY, Yeung MC, Ko JM, Cheung AK, Law EW, Yu Z, Shuen WH, Tung E, Chan SH, Bangarusamy DK, Cheng Y, Yang X, Kan R, Phoon Y, Chan KC, Chua D, Kwong DL, Lee AW, Ji MF, Lung ML. Oncogene. 2015 Feb 12;34(7):878-89. doi: 10.1038/onc.2014.12. Epub 2014 Mar 10. PubMed
Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P/STAT3 Signaling Pathway. Smith GS, Kumar A, Saba JD. Biomolecules. 2013 Jun 24;3(3):351-368. PubMed
Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K. PLoS One. 2014 Apr 9;9(4):e94735. doi: 10.1371/journal.pone.0094735. eCollection 2014. PubMed
Adaptations of energy metabolism associated with increased levels of mitochondrial cholesterol in Niemann-Pick type C1-deficient cells. Kennedy BE, Madreiter CT, Vishnu N, Malli R, Graier WF, Karten B. J Biol Chem. 2014 Jun 6;289(23):16278-89. doi: 10.1074/jbc.M114.559914. Epub 2014 Apr 30. PubMed
Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-beta. Alcaraz LB, Exposito JY, Chuvin N, Pommier RM, Cluzel C, Martel S, Sentis S, Bartholin L, Lethias C, Valcourt U. J Cell Biol. 2014 May 12;205(3):409-28. doi: 10.1083/jcb.201308031. PubMed
Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis. de Renty C, DePamphilis ML, Ullah Z. PLoS One. 2014 May 21;9(5):e97434. doi: 10.1371/journal.pone.0097434. eCollection 2014. PubMed
Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. Hall MD, Marshall TS, Kwit AD, Miller Jenkins LM, Dulcey AE, Madigan JP, Pluchino KM, Goldsborough AS, Brimacombe KR, Griffiths GL, Gottesman MM. J Biol Chem. 2014 Aug 1;289(31):21473-89. doi: 10.1074/jbc.M114.581702. Epub 2014 Jun 14. PubMed
SUMO-2 promotes mRNA translation by enhancing interaction between eIF4E and eIF4G. Chen LZ, Li XY, Huang H, Xing W, Guo W, He J, Sun ZY, Luo AX, Liang HP, Hu J, Wang ZG, Xu YS, Xu X. PLoS One. 2014 Jun 27;9(6):e100457. doi: 10.1371/journal.pone.0100457. eCollection 2014. PubMed
The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker Zhou TB, Harris DA, Abraham CR. J Biol Chem. 2014 Aug 29;289(35):24700-15. doi: 10.1074/jbc.M114.567321. Epub 2014 Jul 18. PubMed
Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1alpha axis. Yao W, Ji S, Qin Y, Yang J, Xu J, Zhang B, Xu W, Liu J, Shi S, Liu L, Liu C, Long J, Ni Q, Li M, Yu X. Mol Cancer. 2014 Aug 7;13:187. doi: 10.1186/1476-4598-13-187. PubMed
Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells. Milewska A, Zarebski M, Nowak P, Stozek K, Potempa J, Pyrc K. J Virol. 2014 Nov;88(22):13221-30. doi: 10.1128/JVI.02078-14. Epub 2014 Sep 3. PubMed
Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment. Kravtsov D, Mashukova A, Forteza R, Rodriguez MM, Ameen NA, Salas PJ. Am J Physiol Gastrointest Liver Physiol. 2014 Nov 15;307(10):G992-G1001. doi: 10.1152/ajpgi.00180.2014. Epub 2014 Sep 25. PubMed
TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway. Neri F, Dettori D, Incarnato D, Krepelova A, Rapelli S, Maldotti M, Parlato C, Paliogiannis P, Oliviero S. Oncogene. 2014 Nov 3. doi: 10.1038/onc.2014.356. PubMed
The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity. Chang KE, Wei BR, Madigan JP, Hall MD, Simpson RM, Zhuang Z, Gottesman MM. Mol Cancer Ther. 2015 Jan;14(1):90-100. doi: 10.1158/1535-7163.MCT-14-0496. Epub 2014 Nov 5. PubMed
Asymmetric dimethylarginine exacerbates Abeta-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease. Luo Y, Yue W, Quan X, Wang Y, Zhao B, Lu Z. Free Radic Biol Med. 2015 Feb;79:117-26. doi: 10.1016/j.freeradbiomed.2014.12.002. Epub 2014 Dec 12. PubMed
Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells. Bayin NS, Modrek AS, Dietrich A, Lebowitz J, Abel T, Song HR, Schober M, Zagzag D, Buchholz CJ, Chao MV, Placantonakis DG. PLoS One. 2014 Dec 26;9(12):e116114. doi: 10.1371/journal.pone.0116114. eCollection 2014. PubMed
Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation. Chen X, Xie W, Gu P, Cai Q, Wang B, Xie Y, Dong W, He W, Zhong G, Lin T, Huang J. Sci Rep. 2015 Feb 6;5:8293. doi: 10.1038/srep08293. PubMed
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. J Clin Invest. 2015 Mar 2;125(3):1147-62. doi: 10.1172/JCI74725. Epub 2015 Feb 9. PubMed
The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, Cristea IM. Mol Syst Biol. 2015 Feb 9;11(1):787. doi: 10.15252/msb.20145808. PubMed
The nucleocapsid protein of human coronavirus NL63. Zuwala K, Golda A, Kabala W, Burmistrz M, Zdzalik M, Nowak P, Kedracka-Krok S, Zarebski M, Dobrucki J, Florek D, Zeglen S, Wojarski J, Potempa J, Dubin G, Pyrc K. PLoS One. 2015 Feb 20;10(2):e0117833. doi: 10.1371/journal.pone.0117833. eCollection 2015. PubMed
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid JA, Herrador R, Vindigni A, Lopes M. J Cell Biol. 2015 Mar 2;208(5):563-79. doi: 10.1083/jcb.201406099. PubMed
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. Ji S, Qin Y, Shi S, Liu X, Hu H, Zhou H, Gao J, Zhang B, Xu W, Liu J, Liang D, Liu L, Liu C, Long J, Zhou H, Chiao PJ, Xu J, Ni Q, Gao D, Yu X. Cell Res. 2015 May;25(5):561-73. doi: 10.1038/cr.2015.30. Epub 2015 Mar 10. PubMed
A versatile orthotopic nude mouse model for study of esophageal squamous cell carcinoma. Ip JC, Ko JM, Yu VZ, Chan KW, Lam AK, Law S, Tong DK, Lung ML. Biomed Res Int. 2015;2015:910715. doi: 10.1155/2015/910715. Epub 2015 Mar 5. PubMed
Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth. Zhu YP, Wan FN, Shen YJ, Wang HK, Zhang GM, Ye DW. Oncotarget. 2015 Jun 10;6(16):14488-96. PubMed
PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma. Cheung AK, Ip JC, Chu AC, Cheng Y, Leong MM, Ko JM, Shuen WH, Lung HL, Lung ML. Oncotarget. 2015 May 30;6(15):13434-47. PubMed
NF-kappaB p65 Subunit Is Modulated by Latent Transforming Growth Factor-beta Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells. Kan R, Shuen WH, Lung HL, Cheung AK, Dai W, Kwong DL, Ng WT, Lee AW, Yau CC, Ngan RK, Tung SY, Lung ML. PLoS One. 2015 May 14;10(5):e0127239. doi: 10.1371/journal.pone.0127239. eCollection 2015. PubMed
Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Cao H, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ. Nat Commun. 2015 Jun 10;6:7209. doi: 10.1038/ncomms8209. PubMed
Cardioprotective HIF-1alpha-frataxin signaling against ischemia-reperfusion injury. Nanayakkara G, Alasmari A, Mouli S, Eldoumani H, Quindry JC, McGinnis G, Fu X, Berlin A, Peters B, Zhong J, Amin RH. Am J Physiol Heart Circ Physiol. 2015 Jun 12:ajpheart.00875.2014. doi: 10.1152/ajpheart.00875.2014. PubMed
Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress. D'Osualdo A, Anania VG, Yu K, Lill JR, Kaufman RJ, Matsuzawa S, Reed JC. PLoS One. 2015 Jun 18;10(6):e0130635. doi: 10.1371/journal.pone.0130635. eCollection 2015. PubMed
The protein arginine methyltransferase PRMT5 regulates Abeta-induced toxicity in human cells and Caenorhabditis elegans models of Alzheimer's disease. Quan X, Yue W, Luo Y, Cao J, Wang H, Wang Y, Lu Z. J Neurochem. 2015 Jun 18. doi: 10.1111/jnc.13191. PubMed
Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL. Souza PS, Madigan JP, Gillet JP, Kapoor K, Ambudkar SV, Maia RC, Gottesman MM, Leung Fung K. Exp Cell Res. 2015 Jun 19. pii: S0014-4827(15)30013-6. doi: 10.1016/j.yexcr.2015.06.005. PubMed
Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition. Taylor IC, Hutt-Cabezas M, Brandt WD, Kambhampati M, Nazarian J, Chang HT, Warren KE, Eberhart CG, Raabe EH. J Neuropathol Exp Neurol. 2015 Aug;74(8):778-90. doi: 10.1097/NEN.0000000000000216. PubMed
Parent stem cells can serve as niches for their daughter cells. Pardo-Saganta A, Tata PR, Law BM, Saez B, Chow RDz, Prabhu M, Gridley T, Rajagopal J. Nature. 2015 Jul 30;523(7562):597-601. doi: 10.1038/nature14553. Epub 2015 Jul 6. PubMed
Down-regulation of poly (ADP-ribose) polymerase-1 by a viral processivity factor facilitates gammaherpesvirus lytic replication. Cheong WC, Park JH, Kang HR, Song MJ. J Virol. 2015 Jul 8. pii: JVI.00559-15. PubMed
Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir. Hui KF, Cheung AK, Choi CK, Yeung PL, Middeldorp JM, Lung ML, Tsao SW, Chiang AK. Int J Cancer. 2016 Jan 1;138(1):125-36. doi: 10.1002/ijc.29698. Epub 2015 Aug 11. PubMed
The role of frataxin in doxorubicin-mediated cardiac hypertrophy. Mouli S, Nanayakkara G, AlAlasmari A, Eldoumani H, Fu X, Berlin A, Lohani M, Nie B, Arnold RD, Kavazis A, Smith F, Beyers R, Denney T, Dhanasekaran M, Zhong J, Quindry J, Amin R. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H844-59. doi: 10.1152/ajpheart.00182.2015. Epub 2015 Jul 24. PubMed
Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells. Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML. Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22. PubMed
Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Martin KA, Cesaroni M, Denny MF, Lupey LN, Tempera I. Mol Cell Biol. 2015 Dec;35(23):3934-44. doi: 10.1128/MCB.00635-15. Epub 2015 Sep 14. PubMed
Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling. Kaduwal S, Jeong WJ, Park JC, Lee KH, Lee YM, Jeon SH, Lim YB, Min do S, Choi KY. Oncotarget. 2015 Oct 20;6(32):33091-105. doi: 10.18632/oncotarget.5173. PubMed
RAL-1 controls multivesicular body biogenesis and exosome secretion. Hyenne V, Apaydin A, Rodriguez D, Spiegelhalter C, Hoff-Yoessle S, Diem M, Tak S, Lefebvre O, Schwab Y, Goetz JG, Labouesse M. J Cell Biol. 2015 Oct 12;211(1):27-37. doi: 10.1083/jcb.201504136. PubMed
Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons. Nair B, Johar K, Priya A, Wong-Riley MT. Biochim Biophys Acta. 2016 Jan;1863(1):1-9. doi: 10.1016/j.bbamcr.2015.10.005. Epub 2015 Oct 18. PubMed
Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component. Moon DH, Segal M, Boyraz B, Guinan E, Hofmann I, Cahan P, Tai AK, Agarwal S. Nat Genet. 2015 Dec;47(12):1482-8. doi: 10.1038/ng.3423. Epub 2015 Oct 19. PubMed
Targeting mitochondrial RNA polymerase in acute myeloid leukemia. Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR. Oncotarget. 2015 Nov 10;6(35):37216-28. doi: 10.18632/oncotarget.6129. PubMed
Ribosome profiling reveals the rhythmic liver translatome and circadian clock regulation by upstream open reading frames. Janich P, Arpat AB, Castelo-Szekely V, Lopes M, Gatfield D. Genome Res. 2015 Dec;25(12):1848-59. doi: 10.1101/gr.195404.115. Epub 2015 Oct 20. PubMed
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. Zucal C, D'Agostino VG, Casini A, Mantelli B, Thongon N, Soncini D, Caffa I, Cea M, Ballestrero A, Quattrone A, Indraccolo S, Nencioni A, Provenzani A. BMC Cancer. 2015 Nov 5;15:855. doi: 10.1186/s12885-015-1845-1. PubMed
High-Throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation. Robitaille K, Rourke JL, McBane JE, Fu A, Baird S, Du Q, Kin T, Shapiro AM, Screaton RA. J Biol Chem. 2016 Jan 6. pii: jbc.M115.683912. PubMed
Store-operated Ca2+ entry-associated regulatory factor (SARAF) plays an important role in the regulation of arachidonate-regulated Ca2+ (ARC) channels. Albarran L, Lopez JJ, Woodard GE, Salido GM, Rosado JA. J Biol Chem. 2016 Jan 27. pii: jbc.M115.704940. PubMed
Sorcin Links Pancreatic beta-Cell Lipotoxicity to ER Ca2+ Stores. Marmugi A, Parnis J, Chen X, Carmichael L, Hardy J, Mannan N, Marchetti P, Piemonti L, Bosco D, Johnson P, Shapiro JA, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Thorens B, Valdivia HH, Rutter GA, Leclerc I. Diabetes. 2016 Apr;65(4):1009-21. doi: 10.2337/db15-1334. Epub 2016 Jan 28. PubMed
ALDOA functions as an oncogene in the highly metastatic pancreatic cancer. Ji S, Zhang B, Liu J, Qin Y, Liang C, Shi S, Jin K, Liang D, Xu W, Xu H, Wang W, Wu C, Liu L, Liu C, Xu J, Ni Q, Yu X. Cancer Lett. 2016 Apr 28;374(1):127-35. doi: 10.1016/j.canlet.2016.01.054. Epub 2016 Feb 12. PubMed
Development of ovine chorionic somatomammotropin hormone-deficient pregnancies. Baker CM, Goetzmann LN, Cantlon JD, Jeckel KM, Winger QA, Anthony RV. Am J Physiol Regul Integr Comp Physiol. 2016 May 1;310(9):R837-46. doi: 10.1152/ajpregu.00311.2015. Epub 2016 Feb 17. PubMed
Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain. Scheckel C, Drapeau E, Frias MA, Park CY, Fak J, Zucker-Scharff I, Kou Y, Haroutunian V, Ma'ayan A, Buxbaum JD, Darnell RB. Elife. 2016 Feb 19;5. pii: e10421. doi: 10.7554/eLife.10421. PubMed
The membrane complement regulatory protein CD59 promotes tumor growth and predicts poor prognosis in breast cancer. Ouyang Q, Zhang L, Jiang Y, Ni X, Chen S, Ye F, Du Y, Huang L, Ding P, Wang N, Yang C, Huang T, Sun Y, Li S, Xia Y, Hu W, Luo R, Shao Z. Int J Oncol. 2016 May;48(5):2015-24. doi: 10.3892/ijo.2016.3408. Epub 2016 Feb 24. PubMed
Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer. Shi RL, Qu N, Liao T, Wang YL, Wang Y, Sun GH, Ji QH. Int J Oncol. 2016 May;48(5):2055-62. doi: 10.3892/ijo.2016.3412. Epub 2016 Mar 2. PubMed
Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models. Shi C, Viccaro K, Lee HG, Shah K. J Cell Sci. 2016 Mar 9. pii: jcs.185009. PubMed
MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer. Zhang B, Xu J, Li C, Shi S, Ji S, Xu W, Liu J, Jin K, Liang D, Liang C, Liu L, Liu C, Qin Y, Yu X. Curr Mol Med. 2016;16(4):404-11. PubMed
VEGF Promotes Glycolysis in Pancreatic Cancer via HIF1alpha Up-Regulation. Shi S, Xu J, Zhang B, Ji S, Xu W, Liu J, Jin K, Liang D, Liang C, Liu L, Liu C, Qin Y, Yu X. Curr Mol Med. 2016;16(4):394-403. PubMed
FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer. Ji S, Qin Y, Liang C, Huang R, Shi S, Liu J, Jin K, Liang D, Xu W, Zhang B, Liu L, Liu C, Xu J, Ni Q, Chiao PJ, Li M, Yu X. Clin Cancer Res. 2016 Aug 1;22(15):3950-60. doi: 10.1158/1078-0432.CCR-15-2380. Epub 2016 Mar 16. PubMed
DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells. Wang H, Guo Y, Liu L, Guan L, Wang T, Zhang L, Wang Y, Cao J, Ding W, Zhang F, Lu Z. Biochim Biophys Acta. 2016 Mar 18. pii: S0304-4165(16)30077-0. doi: 10.1016/j.bbagen.2016.03.022. PubMed
Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry. Albarran L, Lopez JJ, Amor NB, Martin-Cano FE, Berna-Erro A, Smani T, Salido GM, Rosado JA. Sci Rep. 2016 Apr 12;6:24452. doi: 10.1038/srep24452. PubMed
TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. Yan J, Xu J, Fei Y, Jiang C, Zhu W, Han Y, Lu S. Exp Cell Res. 2016 May 15;344(1):67-75. doi: 10.1016/j.yexcr.2016.04.014. Epub 2016 Apr 20. PubMed
Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF. Tyurin-Kuzmin PA, Zhdanovskaya ND, Sukhova AA, Sagaradze GD, Albert EA, Ageeva LV, Sharonov GV, Vorotnikov AV, Tkachuk VA. PLoS One. 2016 Apr 25;11(4):e0154157. doi: 10.1371/journal.pone.0154157. eCollection 2016. PubMed
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed
The Engrailed-1 Gene Stimulates Brown Adipogenesis. Zhang C, Weng Y, Shi F, Jin W. Stem Cells Int. 2016;2016:7369491. doi: 10.1155/2016/7369491. Epub 2016 Apr 11. PubMed
The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4. LeNoue-Newton ML, Wadzinski BE, Spiller BW. Biochem Biophys Res Commun. 2016 Jun 17;475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8. PubMed
The antitumor toxin CD437 is a direct inhibitor of DNA polymerase alpha. Han T, Goralski M, Capota E, Padrick SB, Kim J, Xie Y, Nijhawan D. Nat Chem Biol. 2016 Jul;12(7):511-5. doi: 10.1038/nchembio.2082. Epub 2016 May 16. PubMed
Optogenetic toolkit reveals the role of Ca2+ sparklets in coordinated cell migration. Kim JM, Lee M, Kim N, Heo WD. Proc Natl Acad Sci U S A. 2016 May 24;113(21):5952-7. doi: 10.1073/pnas.1518412113. Epub 2016 May 17. PubMed

Associated Plasmids

A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum. Wu L, Sun Y, Ma L, Zhu J, Zhang B, Pan Q, Li Y, Liu H, Diao A, Li Y. Sci Rep. 2016 Jun 6;6:27332. doi: 10.1038/srep27332. PubMed
The long intergenic non-coding RNA CCR492 functions as a let-7 competitive endogenous RNA to regulate c-Myc expression. Maldotti M, Incarnato D, Neri F, Krepelova A, Rapelli S, Anselmi F, Parlato C, Basile G, Dettori D, Calogero R, Oliviero S. Biochim Biophys Acta. 2016 Jun 23. pii: S1874-9399(16)30131-6. doi: 10.1016/j.bbagrm.2016.06.010. PubMed
Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma. Li Q, Qin Y, Wei P, Lian P, Li Y, Xu Y, Li X, Li D, Cai S. Mol Cancer Res. 2016 Sep;14(9):830-40. doi: 10.1158/1541-7786.MCR-16-0032. Epub 2016 Jul 11. PubMed
Selenoprotein O deficiencies suppress chondrogenic differentiation of ATDC5 cells. Yan J, Fei Y, Han Y, Lu S. Cell Biol Int. 2016 Oct;40(10):1033-40. doi: 10.1002/cbin.10644. Epub 2016 Jul 28. PubMed
Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. Martin KA, Lupey LN, Tempera I. J Virol. 2016 Sep 12;90(19):8520-30. doi: 10.1128/JVI.01180-16. Print 2016 Oct 1. PubMed
LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. Sas-Chen A, Aure MR, Leibovich L, Carvalho S, Enuka Y, Korner C, Polycarpou-Schwarz M, Lavi S, Nevo N, Kuznetsov Y, Yuan J, Azuaje F, Ulitsky I, Diederichs S, Wiemann S, Yakhini Z, Kristensen VN, Borresen-Dale AL, Yarden Y. EMBO Mol Med. 2016 Sep 1;8(9):1052-64. doi: 10.15252/emmm.201606198. PubMed
Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus. Hastie E, Cataldi M, Moerdyk-Schauwecker MJ, Felt SA, Steuerwald N, Grdzelishvili VZ. Oncotarget. 2016 Sep 20;7(38):61601-61618. doi: 10.18632/oncotarget.11202. PubMed
Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion. Nath S, Christian L, Tan SY, Ki S, Ehrlich LI, Poenie M. J Immunol. 2016 Sep 15;197(6):2090-101. doi: 10.4049/jimmunol.1600180. Epub 2016 Aug 17. PubMed
Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell. 2016 Aug 25;166(5):1147-1162.e15. doi: 10.1016/j.cell.2016.07.025. PubMed
High-throughput single-base resolution mapping of RNA 2'-O-methylated residues. Incarnato D, Anselmi F, Morandi E, Neri F, Maldotti M, Rapelli S, Parlato C, Basile G, Oliviero S. Nucleic Acids Res. 2016 Sep 9. pii: gkw810. PubMed
Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kappaB pathway regulators in nasopharyngeal carcinoma. Zheng H, Dai W, Cheung AK, Ko JM, Kan R, Wong BW, Leong MM, Deng M, Kwok TC, Chan JY, Kwong DL, Lee AW, Ng WT, Ngan RK, Yau CC, Tung S, Lee VH, Lam KO, Kwan CK, Li WS, Yau S, Chan KW, Lung ML. Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11283-11288. Epub 2016 Sep 19. PubMed
Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. Carr RM, Qiao G, Qin J, Jayaraman S, Prabhakar BS, Maker AV. Cell Death Discov. 2016 Sep 12;2:16067. doi: 10.1038/cddiscovery.2016.67. eCollection 2016. PubMed
mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease. Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS. Alzheimers Dement. 2016 Sep 29. pii: S1552-5260(16)32895-3. doi: 10.1016/j.jalz.2016.08.015. PubMed
Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Koch K, Hartmann R, Schroter F, Suwala AK, Maciaczyk D, Kruger AC, Willbold D, Kahlert UD, Maciaczyk J. Oncotarget. 2016 Nov 8;7(45):73414-73431. doi: 10.18632/oncotarget.12337. PubMed
The High Level of Aberrant Splicing of ISCU in Slow-Twitch Muscle May Involve the Splicing Factor SRSF3. Rawcliffe DF, Osterman L, Lindsten H, Holmberg M. PLoS One. 2016 Oct 26;11(10):e0165453. doi: 10.1371/journal.pone.0165453. eCollection 2016. PubMed
The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and delta-Catenin Signaling. Gilbert J, Man HY. eNeuro. 2016 Oct 28;3(5). pii: ENEURO.0238-16.2016. eCollection 2016 Sep-Oct. PubMed
CORALINA: a universal method for the generation of gRNA libraries for CRISPR-based screening. Koferle A, Worf K, Breunig C, Baumann V, Herrero J, Wiesbeck M, Hutter LH, Gotz M, Fuchs C, Beck S, Stricker SH. BMC Genomics. 2016 Nov 14;17(1):917. PubMed
Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells. Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, Skladanowski AC, Zaczek AJ, Biernat W, Kordek R, Romanska HM, Sadej R. Oncotarget. 2016 Dec 27;7(52):86011-86025. doi: 10.18632/oncotarget.13322. PubMed
Knockdown of PTRF ameliorates adipocyte differentiation and functionality of human mesenchymal stem cells. Perez-Diaz S, Garcia-Rodriguez B, Gonzalez-Irazabal Y, Valero M, Lagos-Lizan J, Arbones-Mainar JM. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C83-C91. doi: 10.1152/ajpcell.00246.2016. Epub 2016 Nov 16. PubMed
Heterogeneous nuclear ribonucleoprotein K is associated with poor prognosis and regulates proliferation and apoptosis in bladder cancer. Chen X, Gu P, Xie R, Han J, Liu H, Wang B, Xie W, Xie W, Zhong G, Chen C, Xie S, Jiang N, Lin T, Huang J. J Cell Mol Med. 2016 Nov 10. doi: 10.1111/jcmm.12999. PubMed
Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin. Keyes BE, Liu S, Asare A, Naik S, Levorse J, Polak L, Lu CP, Nikolova M, Pasolli HA, Fuchs E. Cell. 2016 Nov 17;167(5):1323-1338.e14. doi: 10.1016/j.cell.2016.10.052. PubMed
A20 inhibits lipopolysaccharide-induced inflammation in enterocytes. Zheng CF, Shi JR, Huang Y, Wang SN. World J Gastrointest Pharmacol Ther. 2016 Nov 6;7(4):540-549. PubMed
NRL-Regulated Transcriptome Dynamics of Developing Rod Photoreceptors. Kim JW, Yang HJ, Brooks MJ, Zelinger L, Karakulah G, Gotoh N, Boleda A, Gieser L, Giuste F, Whitaker DT, Walton A, Villasmil R, Barb JJ, Munson PJ, Kaya KD, Chaitankar V, Cogliati T, Swaroop A. Cell Rep. 2016 Nov 22;17(9):2460-2473. doi: 10.1016/j.celrep.2016.10.074. PubMed
A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron. Wang Y, Shen Y, Dai Q, Yang Q, Zhang Y, Wang X, Xie W, Luo Z, Lin C. Nucleic Acids Res. 2016 Nov 28. pii: gkw1051. PubMed
Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression. Paschos K, Bazot Q, Ho G, Parker GA, Lees J, Barton G, Allday MJ. Nucleic Acids Res. 2016 Nov 29. pii: gkw1167. PubMed
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KK, Tong KK, Kwan KM, Wang N, Chiu JJ, Zhu Y, Huang Y. Nature. 2016 Dec 7. doi: 10.1038/nature20602. PubMed

Associated Plasmids

WIP promotes in-vitro invasion ability, anchorage independent growth and EMT progression of A549 lung adenocarcinoma cells by regulating RhoA levels. Salvi A, Thanabalu T. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1353-1359. doi: 10.1016/j.bbrc.2016.12.040. Epub 2016 Dec 7. PubMed
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer. Liang C, Qin Y, Zhang B, Ji S, Shi S, Xu W, Liu J, Xiang J, Liang D, Hu Q, Ni Q, Yu X, Xu J. Cancer Lett. 2016 Dec 23;388:303-311. doi: 10.1016/j.canlet.2016.12.014. PubMed
Molecular cloning and characterization of the porcine ribosomal protein L21. Sun WS, Chun JL, Kim DH, Ahn JS, Kim MK, Hwang IS, Kwon DJ, Hwang SS, Lee JW. J Vet Sci. 2017 Jan 4. PubMed
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer. Cai X, Ding H, Liu Y, Pan G, Li Q, Yang Z, Liu W. Acta Biochim Biophys Sin (Shanghai). 2017 Feb 6;49(2):119-127. doi: 10.1093/abbs/gmw124. PubMed
Monomethyltransferase SETD8 regulates breast cancer metabolism via stabilizing hypoxia-inducible factor 1alpha. Huang R, Yu Y, Zong X, Li X, Ma L, Zheng Q. Cancer Lett. 2017 Apr 1;390:1-10. doi: 10.1016/j.canlet.2016.12.038. Epub 2017 Jan 13. PubMed
Parvovirus Expresses a Small Noncoding RNA That Plays an Essential Role in Virus Replication. Wang Z, Shen W, Cheng F, Deng X, Engelhardt JF, Yan Z, Qiu J. J Virol. 2017 Mar 29;91(8). pii: JVI.02375-16. doi: 10.1128/JVI.02375-16. Print 2017 Apr 15. PubMed
Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltran J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT. J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30. PubMed
Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology. Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PP. J Cell Sci. 2017 Mar 1;130(5):903-915. doi: 10.1242/jcs.195263. Epub 2017 Jan 30. PubMed
Cdk5-Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models. Shi C, Viccaro K, Lee HG, Shah K. J Cell Sci. 2016 May 1;129(9):1815-1830. doi: 10.1242/jcs.185009. Epub 2016 Mar 9. PubMed
A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron. Wang Y, Shen Y, Dai Q, Yang Q, Zhang Y, Wang X, Xie W, Luo Z, Lin C. Nucleic Acids Res. 2017 Feb 17;45(3):1177-1185. doi: 10.1093/nar/gkw1051. PubMed
High-throughput single-base resolution mapping of RNA 2-O-methylated residues. Incarnato D, Anselmi F, Morandi E, Neri F, Maldotti M, Rapelli S, Parlato C, Basile G, Oliviero S. Nucleic Acids Res. 2017 Feb 17;45(3):1433-1441. doi: 10.1093/nar/gkw810. PubMed
Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target. Etxabe A, Lara-Castillo MC, Cornet-Masana JM, Banus-Mulet A, Nomdedeu M, Torrente MA, Pratcorona M, Diaz-Beya M, Esteve J, Risueno RM. Leukemia. 2017 Nov;31(11):2288-2302. doi: 10.1038/leu.2017.52. Epub 2017 Feb 14. PubMed
MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase. Vidoni S, Harbour ME, Guerrero-Castillo S, Signes A, Ding S, Fearnley IM, Taylor RW, Tiranti V, Arnold S, Fernandez-Vizarra E, Zeviani M. Cell Rep. 2017 Feb 14;18(7):1727-1738. doi: 10.1016/j.celrep.2017.01.044. PubMed
Intragenic DNA methylation prevents spurious transcription initiation. Neri F, Rapelli S, Krepelova A, Incarnato D, Parlato C, Basile G, Maldotti M, Anselmi F, Oliviero S. Nature. 2017 Mar 2;543(7643):72-77. doi: 10.1038/nature21373. Epub 2017 Feb 22. PubMed
Prototype foamy virus elicits complete autophagy involving the ER stress-related UPR pathway. Yuan P, Dong L, Cheng Q, Wang S, Li Z, Sun Y, Han S, Yin J, Peng B, He X, Liu W. Retrovirology. 2017 Mar 7;14(1):16. doi: 10.1186/s12977-017-0341-x. PubMed
Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells. Hutz K, Zeiler J, Sachs L, Ormanns S, Spindler V. Mol Carcinog. 2017 Aug;56(8):1884-1895. doi: 10.1002/mc.22644. Epub 2017 Mar 30. PubMed
PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase. Coomans de Brachene A, Dif N, de Rocca Serra A, Bonnineau C, Velghe AI, Larondelle Y, Tyteca D, Demoulin JB. FEBS Open Bio. 2017 Feb 2;7(3):414-423. doi: 10.1002/2211-5463.12194. eCollection 2017 Mar. PubMed
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs. Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T. Nature. 2017 Mar 23;543(7646):568-572. doi: 10.1038/nature21690. Epub 2017 Mar 15. PubMed

Associated Plasmids

Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells. Ejaz A, Mattesich M, Zwerschke W. Aging (Albany NY). 2017 Mar 17;9(3):860-879. doi: 10.18632/aging.101197. PubMed
Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation. Su X, Liu S, Zhang X, Lam SM, Hu X, Zhou Y, Chen J, Wang Y, Wu C, Shui G, Lu M, Pei R, Chen X. Biochim Biophys Acta. 2017 Jul;1862(7):692-705. doi: 10.1016/j.bbalip.2017.03.007. Epub 2017 Mar 21. PubMed
SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl1 pathway. Qu N, Hu JQ, Liu L, Zhang TT, Sun GH, Shi RL, Ji QH. Int J Oncol. 2017 May;50(5):1683-1692. doi: 10.3892/ijo.2017.3951. Epub 2017 Apr 5. PubMed
Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells. Liu Z, Dai X, Wang T, Zhang C, Zhang W, Zhang W, Zhang Q, Wu K, Liu F, Liu Y, Wu J. Cancer Lett. 2017 Aug 1;400:149-160. doi: 10.1016/j.canlet.2017.04.017. Epub 2017 Apr 25. PubMed
Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain. Solek CM, Feng S, Perin S, Weinschutz Mendes H, Ekker M. Dev Biol. 2017 Jul 1;427(1):131-147. doi: 10.1016/j.ydbio.2017.04.019. Epub 2017 May 4. PubMed
lncRNA HOXD-AS1 Regulates Proliferation and Chemo-Resistance of Castration-Resistant Prostate Cancer via Recruiting WDR5. Gu P, Chen X, Xie R, Han J, Xie W, Wang B, Dong W, Chen C, Yang M, Jiang J, Chen Z, Huang J, Lin T. Mol Ther. 2017 Aug 2;25(8):1959-1973. doi: 10.1016/j.ymthe.2017.04.016. Epub 2017 May 6. PubMed
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz OH, Xue W, Katajisto P, Bhutkar A, Jacks T. Nature. 2017 May 18;545(7654):355-359. doi: 10.1038/nature22334. Epub 2017 May 10. PubMed
An Ethanolic Extract of Ampelopsis Radix Exerts Anti-colorectal Cancer Effects and Potently Inhibits STAT3 Signaling In Vitro. Su T, Bai JX, Chen YJ, Wang XN, Fu XQ, Li T, Guo H, Zhu PL, Wang Y, Yu ZL. Front Pharmacol. 2017 Apr 28;8:227. doi: 10.3389/fphar.2017.00227. eCollection 2017. PubMed
Exogenous BDNF Increases Mitochondrial pCREB and Alleviates Neuronal Metabolic Defects Following Mechanical Injury in a MPTP-Dependent Way. Xu Z, Lv XA, Dai Q, Lu M, Jin Z. Mol Neurobiol. 2017 May 15. doi: 10.1007/s12035-017-0576-5. PubMed
Expression and prognostic value of glutamate dehydrogenase in extrahepatic cholangiocarcinoma patients. Su Z, Liu G, Fang T, Zhang K, Yang S, Zhang H, Wang Y, Lv Z, Liu J. Am J Transl Res. 2017 May 15;9(5):2106-2118. eCollection 2017. PubMed
CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells. Maciaczyk D, Picard D, Zhao L, Koch K, Herrera-Rios D, Li G, Marquardt V, Pauck D, Hoerbelt T, Zhang W, Ouwens DM, Remke M, Jiang T, Steiger HJ, Maciaczyk J, Kahlert UD. Br J Cancer. 2017 Jun 27;117(1):102-112. doi: 10.1038/bjc.2017.157. Epub 2017 Jun 1. PubMed
Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine. Ahsan MK, Tchernychev B, Kessler MM, Solinga RM, Arthur D, Linde CI, Silos-Santiago I, Hannig G, Ameen NA. Physiol Rep. 2017 Jun;5(11). pii: 5/11/e13299. doi: 10.14814/phy2.13299. PubMed
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice. Shi L, Zhao C, Wang H, Lei T, Liu S, Cao J, Lu Z. Antioxid Redox Signal. 2017 Dec 1;27(16):1347-1360. doi: 10.1089/ars.2017.7022. Epub 2017 Jul 7. PubMed
Glycolytic reliance promotes anabolism in photoreceptors. Chinchore Y, Begaj T, Wu D, Drokhlyansky E, Cepko CL. Elife. 2017 Jun 9;6. pii: e25946. doi: 10.7554/eLife.25946. PubMed
BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ. J Cell Biol. 2017 Jul 3;216(7):2151-2166. doi: 10.1083/jcb.201702099. Epub 2017 Jun 16. PubMed
HOXB7 accelerates the malignant progression of hepatocellular carcinoma by promoting stemness and epithelial-mesenchymal transition. Huan HB, Yang DP, Wen XD, Chen XJ, Zhang L, Wu LL, Bie P, Xia F. J Exp Clin Cancer Res. 2017 Jun 24;36(1):86. doi: 10.1186/s13046-017-0559-4. PubMed
CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target: Role of CPSF6 in Breast Cancer. Binothman N, Hachim IY, Lebrun JJ, Ali S. EBioMedicine. 2017 Jul;21:65-78. doi: 10.1016/j.ebiom.2017.06.023. Epub 2017 Jun 24. PubMed
Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells. Ju T, Jin H, Ying R, Xie Q, Zhou C, Gao D. Mol Med Rep. 2017 Sep;16(3):3194-3200. doi: 10.3892/mmr.2017.6986. Epub 2017 Jul 14. PubMed
Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. Liu J, Zhao YJ, Li WH, Hou YN, Li T, Zhao ZY, Fang C, Li SL, Lee HC. Proc Natl Acad Sci U S A. 2017 Jul 18. pii: 1703718114. doi: 10.1073/pnas.1703718114. PubMed
The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer's disease. Nikhil K, Shah K. J Cell Sci. 2017 Sep 15;130(18):3023-3039. doi: 10.1242/jcs.205666. Epub 2017 Jul 27. PubMed
Establishment of highly metastatic KRAS mutant lung cancer cell sublines in long-term three-dimensional low attachment cultures. Nakano T, Kanai Y, Amano Y, Yoshimoto T, Matsubara D, Shibano T, Tamura T, Oguni S, Katashiba S, Ito T, Murakami Y, Fukayama M, Murakami T, Endo S, Niki T. PLoS One. 2017 Aug 7;12(8):e0181342. doi: 10.1371/journal.pone.0181342. eCollection 2017. PubMed
Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP. Zhang D, Yang S, Toledo EM, Gyllborg D, Salto C, Carlos Villaescusa J, Arenas E. Sci Signal. 2017 Aug 22;10(493). pii: 10/493/eaal4165. doi: 10.1126/scisignal.aal4165. PubMed
Hemidesmosomal linker proteins regulate cell motility, invasion and tumorigenicity in oral squamous cell carcinoma derived cells. Chaudhari PR, Charles SE, D'Souza ZC, Vaidya MM. Exp Cell Res. 2017 Nov 15;360(2):125-137. doi: 10.1016/j.yexcr.2017.08.034. Epub 2017 Sep 1. PubMed
Identification of hypoxia-regulated angiogenic genes in colorectal cancer. Zong S, Li W, Li H, Han S, Liu S, Shi Q, Hou F. Biochem Biophys Res Commun. 2017 Nov 4;493(1):461-467. doi: 10.1016/j.bbrc.2017.08.169. Epub 2017 Sep 18. PubMed
NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Song N, Liu ZS, Xue W, Bai ZF, Wang QY, Dai J, Liu X, Huang YJ, Cai H, Zhan XY, Han QY, Wang H, Chen Y, Li HY, Li AL, Zhang XM, Zhou T, Li T. Mol Cell. 2017 Oct 5;68(1):185-197.e6. doi: 10.1016/j.molcel.2017.08.017. Epub 2017 Sep 21. PubMed
Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancer. Quintero M, Adamoski D, Reis LMD, Ascencao CFR, Oliveira KRS, Goncalves KA, Dias MM, Carazzolle MF, Dias SMG. BMC Cancer. 2017 Nov 7;17(1):727. doi: 10.1186/s12885-017-3726-2. PubMed

Associated Plasmids

Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution. Fei J, Jadaliha M, Harmon TS, Li ITS, Hua B, Hao Q, Holehouse AS, Reyer M, Sun Q, Freier SM, Pappu RV, Prasanth KV, Ha T. J Cell Sci. 2017 Dec 15;130(24):4180-4192. doi: 10.1242/jcs.206854. Epub 2017 Nov 13. PubMed
Interleukin-6 Mediates Post-Infarct Repair by Cardiac Explant-Derived Stem Cells. Mayfield AE, Kanda P, Nantsios A, Parent S, Mount S, Dixit S, Ye B, Seymour R, Stewart DJ, Davis DR. Theranostics. 2017 Oct 17;7(19):4850-4861. doi: 10.7150/thno.19435. eCollection 2017. PubMed
Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map. Smith I, Greenside PG, Natoli T, Lahr DL, Wadden D, Tirosh I, Narayan R, Root DE, Golub TR, Subramanian A, Doench JG. PLoS Biol. 2017 Nov 30;15(11):e2003213. doi: 10.1371/journal.pbio.2003213. eCollection 2017 Nov. PubMed
Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Jafferali MH, Figueroa RA, Hasan M, Hallberg E. Sci Rep. 2017 Nov 30;7(1):16655. doi: 10.1038/s41598-017-16746-y. PubMed
SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis. Huang R, Li X, Yu Y, Ma L, Liu S, Zong X, Zheng Q. Oncotarget. 2017 Oct 6;8(55):94080-94090. doi: 10.18632/oncotarget.21583. eCollection 2017 Nov 7. PubMed
Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP. Jakka P, Bhargavi B, Namani S, Murugan S, Splitter G, Radhakrishnan G. J Immunol. 2018 Jan 15;200(2):704-714. doi: 10.4049/jimmunol.1601559. Epub 2017 Dec 8. PubMed
Cytoplasmic Cl(-) couples membrane remodeling to epithelial morphogenesis. He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11161-E11169. doi: 10.1073/pnas.1714448115. Epub 2017 Dec 11. PubMed
Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Pan R, Ruvolo V, Mu H, Leverson JD, Nichols G, Reed JC, Konopleva M, Andreeff M. Cancer Cell. 2017 Dec 11;32(6):748-760.e6. doi: 10.1016/j.ccell.2017.11.003. PubMed
ATF4 regulated by MYC has an important function in anoikis resistance in human osteosarcoma cells. Mo H, Guan J, Mo L, He J, Wu Z, Lin X, Liu B, Yuan Z. Mol Med Rep. 2018 Mar;17(3):3658-3666. doi: 10.3892/mmr.2017.8296. Epub 2017 Dec 18. PubMed
Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin-proteasome pathway. Chen C, Ma X, Hu Q, Li X, Huang F, Zhang J, Pan T, Xia J, Liu C, Zhang H. Retrovirology. 2017 Dec 19;14(1):56. doi: 10.1186/s12977-017-0382-1. PubMed
HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target. Fok JHL, Hedayat S, Zhang L, Aronson LI, Mirabella F, Pawlyn C, Bright MD, Wardell CP, Keats JJ, De Billy E, Rye CS, Chessum NEA, Jones K, Morgan GJ, Eccles SA, Workman P, Davies FE. Clin Cancer Res. 2018 May 15;24(10):2395-2407. doi: 10.1158/1078-0432.CCR-17-1594. Epub 2018 Feb 1. PubMed
Lrp6 is a target of the PTH-activated alphaNAC transcriptional coregulator. Pellicelli M, Hariri H, Miller JA, St-Arnaud R. Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):61-71. doi: 10.1016/j.bbagrm.2018.01.008. Epub 2018 Feb 3. PubMed
RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling. Qi ZH, Xu HX, Zhang SR, Xu JZ, Li S, Gao HL, Jin W, Wang WQ, Wu CT, Ni QX, Yu XJ, Liu L. Int J Oncol. 2018 Apr;52(4):1105-1116. doi: 10.3892/ijo.2018.4269. Epub 2018 Feb 7. PubMed
Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells. Zhou Z, Li M, Zhang L, Zhao H, Sahin O, Chen J, Zhao JJ, Songyang Z, Yu D. Cancer Res. 2018 May 1;78(9):2248-2261. doi: 10.1158/0008-5472.CAN-17-2726. Epub 2018 Feb 12. PubMed
Rotaviral nonstructural protein 4 triggers dynamin-related protein 1-dependent mitochondrial fragmentation during infection. Mukherjee A, Patra U, Bhowmick R, Chawla-Sarkar M. Cell Microbiol. 2018 Jun;20(6):e12831. doi: 10.1111/cmi.12831. Epub 2018 Feb 28. PubMed
TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1alpha axis and indicates prognosis in pancreatic cancer. Xiang J, Hu Q, Qin Y, Ji S, Xu W, Liu W, Shi S, Liang C, Liu J, Meng Q, Liang D, Ni Q, Xu J, Zhang B, Yu X. Cell Death Dis. 2018 Feb 23;9(3):321. doi: 10.1038/s41419-018-0367-6. PubMed
Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ. Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, Yuan J, Zhang K, Liu Z, Deng Y, Xiao G, Wu C. J Cell Biol. 2018 Apr 2;217(4):1431-1451. doi: 10.1083/jcb.201612177. Epub 2018 Mar 1. PubMed
The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution. Sobajima T, Yoshimura SI, Maeda T, Miyata H, Miyoshi E, Harada A. J Cell Biol. 2018 May 7;217(5):1777-1796. doi: 10.1083/jcb.201709123. Epub 2018 Mar 7. PubMed
Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Johnson JS, Lucas SY, Amon LM, Skelton S, Nazitto R, Carbonetti S, Sather DN, Littman DR, Aderem A. Cell Host Microbe. 2018 Mar 14;23(3):366-381.e9. doi: 10.1016/j.chom.2018.01.012. PubMed
lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Xie W, Yang D. Cancer Cell. 2018 Apr 9;33(4):706-720.e9. doi: 10.1016/j.ccell.2018.03.006. Epub 2018 Apr 2. PubMed
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP. Mol Cell. 2018 May 3;70(3):408-421.e8. doi: 10.1016/j.molcel.2018.03.005. Epub 2018 Apr 5. PubMed

Associated Plasmids

CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer. Raposo TP, Comes MS, Idowu A, Agit B, Hassall J, Fadhil W, Nica R, Ecker R, Yao T, Ilyas M. Exp Mol Pathol. 2018 Jun;104(3):190-198. doi: 10.1016/j.yexmp.2018.04.002. Epub 2018 Apr 11. PubMed
GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. Wang Y, Lei T, Yuan J, Wu Y, Shen X, Gao J, Feng W, Lu Z. Redox Biol. 2018 Jul;17:25-34. doi: 10.1016/j.redox.2018.04.009. Epub 2018 Apr 7. PubMed
CBX3 promotes proliferation and regulates glycolysis via suppressing FBP1 in pancreatic cancer. Chen LY, Cheng CS, Qu C, Wang P, Chen H, Meng ZQ, Chen Z. Biochem Biophys Res Commun. 2018 Jun 7;500(3):691-697. doi: 10.1016/j.bbrc.2018.04.137. Epub 2018 Apr 22. PubMed
Yes-associated protein mediates human embryonic stem cell-derived cardiomyocyte proliferation: Involvement of epidermal growth factor receptor signaling. Park S, Choe M, Yeo H, Han H, Kim J, Chang W, Yun S, Lee H, Lee M. J Cell Physiol. 2018 Oct;233(10):7016-7025. doi: 10.1002/jcp.26625. Epub 2018 Apr 25. PubMed
AMPKalpha2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction. Wang H, Shen X, Tian G, Shi X, Huang W, Wu Y, Sun L, Peng C, Liu S, Huang Y, Chen X, Zhang F, Chen Y, Ding W, Lu Z. Free Radic Biol Med. 2018 Jun;121:202-214. doi: 10.1016/j.freeradbiomed.2018.05.008. Epub 2018 May 10. PubMed
Agrin has a pathological role in the progression of oral cancer. Rivera C, Zandonadi FS, Sanchez-Romero C, Soares CD, Granato DC, Gonzalez-Arriagada WA, Paes Leme AF. Br J Cancer. 2018 Jun;118(12):1628-1638. doi: 10.1038/s41416-018-0135-5. Epub 2018 Jun 6. PubMed
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis. Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen DG, Watts J, Vega F, Nimer SD. Cancer Cell. 2018 Jun 11;33(6):1111-1127.e5. doi: 10.1016/j.ccell.2018.05.007. PubMed
CDK2 positively regulates aerobic glycolysis by suppressing SIRT5 in gastric cancer. Tang Z, Li L, Tang Y, Xie D, Wu K, Wei W, Xiao Q. Cancer Sci. 2018 Aug;109(8):2590-2598. doi: 10.1111/cas.13691. Epub 2018 Jul 10. PubMed
NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer. Zhang TT, Qu N, Sun GH, Zhang L, Wang YJ, Mu XM, Wei WJ, Wang YL, Wang Y, Ji QH, Zhu YX, Shi RL. Int J Oncol. 2018 Aug;53(2):685-693. doi: 10.3892/ijo.2018.4426. Epub 2018 May 31. PubMed
Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice. Fan L, Lu Y, Shen X, Shao H, Suo L, Wu Q. Elife. 2018 Jun 18;7. pii: 35242. doi: 10.7554/eLife.35242. PubMed
Actomyosin stress fiber subtypes have unique viscoelastic properties and roles in tension generation. Lee S, Kassianidou E, Kumar S. Mol Biol Cell. 2018 Aug 8;29(16):1992-2004. doi: 10.1091/mbc.E18-02-0106. Epub 2018 Jun 21. PubMed
Frontal Bone Healing Is Sensitive to Wnt Signaling Inhibition via Lentiviral-Encoded Beta-Catenin Short Hairpin RNA. Zhang L, Chang L, Xu J, Meyers CA, Yan N, Zou E, Ding C, Ting K, Soo C, Pang S, James AW. Tissue Eng Part A. 2018 Aug 20. doi: 10.1089/ten.TEA.2017.0465. PubMed
A Ca(2+)-stimulated exosome release pathway in cancer cells is regulated by Munc13-4. Messenger SW, Woo SS, Sun Z, Martin TFJ. J Cell Biol. 2018 Aug 6;217(8):2877-2890. doi: 10.1083/jcb.201710132. Epub 2018 Jun 21. PubMed
Multifaceted Regulation of ALDH1A1 by Cdk5 in Alzheimer's Disease Pathogenesis. Nikhil K, Viccaro K, Shah K. Mol Neurobiol. 2019 Feb;56(2):1366-1390. doi: 10.1007/s12035-018-1114-9. Epub 2018 Jun 8. PubMed
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Viswanathan SR, Nogueira MF, Buss CG, Krill-Burger JM, Wawer MJ, Malolepsza E, Berger AC, Choi PS, Shih J, Taylor AM, Tanenbaum B, Pedamallu CS, Cherniack AD, Tamayo P, Strathdee CA, Lage K, Carr SA, Schenone M, Bhatia SN, Vazquez F, Tsherniak A, Hahn WC, Meyerson M. Nat Genet. 2018 Jul;50(7):937-943. doi: 10.1038/s41588-018-0155-3. Epub 2018 Jun 28. PubMed
CBFbeta-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. Cell. 2018 Jun 28;174(1):172-186.e21. doi: 10.1016/j.cell.2018.05.048. PubMed
GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. Liu S, Yuan J, Yue W, Bi Y, Shen X, Gao J, Xu X, Lu Z. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3257-3267. doi: 10.1016/j.bbadis.2018.07.012. Epub 2018 Jul 11. PubMed
The concerted roles of FANCM and Rad52 in the protection of common fragile sites. Wang H, Li S, Oaks J, Ren J, Li L, Wu X. Nat Commun. 2018 Jul 18;9(1):2791. doi: 10.1038/s41467-018-05066-y. PubMed
Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Hua JT, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, Lu J, Zhou S, Wang M, Li H, Larson NB, McDonnell SK, Patel PS, Liang Y, Yao CQ, van der Kwast T, Lupien M, Feng FY, Zoubeidi A, Tsao MS, Thibodeau SN, Boutros PC, He HH. Cell. 2018 Jul 26;174(3):564-575.e18. doi: 10.1016/j.cell.2018.06.014. Epub 2018 Jul 19. PubMed
The actin filament bundling protein alpha-actinin-4 actually suppresses actin stress fibers by permitting actin turnover. Kemp JP Jr, Brieher WM. J Biol Chem. 2018 Sep 14;293(37):14520-14533. doi: 10.1074/jbc.RA118.004345. Epub 2018 Jul 26. PubMed
The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. Padilla-Rodriguez M, Parker SS, Adams DG, Westerling T, Puleo JI, Watson AW, Hill SM, Noon M, Gaudin R, Aaron J, Tong D, Roe DJ, Knudsen B, Mouneimne G. Nat Commun. 2018 Jul 30;9(1):2980. doi: 10.1038/s41467-018-05367-2. PubMed

Associated Plasmids

A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Piragyte I, Clapes T, Polyzou A, Klein Geltink RI, Lefkopoulos S, Yin N, Cauchy P, Curtis JD, Klaeyle L, Langa X, Beckmann CCA, Wlodarski MW, Muller P, Van Essen D, Rambold A, Kapp FG, Mione M, Buescher JM, Pearce EL, Polyzos A, Trompouki E. Nat Commun. 2018 Aug 6;9(1):3090. doi: 10.1038/s41467-018-05311-4. PubMed
Circ-BPTF promotes bladder cancer progression and recurrence through the miR-31-5p/RAB27A axis. Bi J, Liu H, Cai Z, Dong W, Jiang N, Yang M, Huang J, Lin T. Aging (Albany NY). 2018 Aug 9;10(8):1964-1976. doi: 10.18632/aging.101520. PubMed
Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex. Ghosh K, Tang M, Kumari N, Nandy A, Basu S, Mall DP, Rai K, Biswas D. Cell Rep. 2018 Aug 21;24(8):2141-2154.e6. doi: 10.1016/j.celrep.2018.07.064. PubMed
Loss of GCNT2/I-branched glycans enhances melanoma growth and survival. Sweeney JG, Liang J, Antonopoulos A, Giovannone N, Kang S, Mondala TS, Head SR, King SL, Tani Y, Brackett D, Dell A, Murphy GF, Haslam SM, Widlund HR, Dimitroff CJ. Nat Commun. 2018 Aug 22;9(1):3368. doi: 10.1038/s41467-018-05795-0. PubMed
Rapamycin Upregulates Connective Tissue Growth Factor Expression in Hepatic Progenitor Cells Through TGF-beta-Smad2 Dependent Signaling. Wu Y, Wang W, Peng XM, He Y, Xiong YX, Liang HF, Chu L, Zhang BX, Ding ZY, Chen XP. Front Pharmacol. 2018 Aug 8;9:877. doi: 10.3389/fphar.2018.00877. eCollection 2018. PubMed
A DNA-sensing-independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-kappaB-mediated innate immunity against DNA virus infection. Ng YC, Chung WC, Kang HR, Cho HJ, Park EB, Kang SJ, Song MJ. Nucleic Acids Res. 2018 Sep 28;46(17):9011-9026. doi: 10.1093/nar/gky742. PubMed
The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y. J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24. PubMed
HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction. Akiyama H, Miller CM, Ettinger CR, Belkina AC, Snyder-Cappione JE, Gummuluru S. Nat Commun. 2018 Aug 27;9(1):3450. doi: 10.1038/s41467-018-05899-7. PubMed
G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. Huang Z, Liang N, Damdimopoulos A, Fan R, Treuter E. FASEB J. 2019 Feb;33(2):1631-1643. doi: 10.1096/fj.201801123R. Epub 2018 Aug 28. PubMed
Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition. Jia D, Augert A, Kim DW, Eastwood E, Wu N, Ibrahim AH, Kim KB, Dunn CT, Pillai SPS, Gazdar AF, Bolouri H, Park KS, MacPherson D. Cancer Discov. 2018 Nov;8(11):1422-1437. doi: 10.1158/2159-8290.CD-18-0385. Epub 2018 Sep 4. PubMed
Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Jiang Y, Jiang YY, Xie JJ, Mayakonda A, Hazawa M, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, Liao LD, Soukiasian HJ, Berman BP, Hao JJ, Xu LY, Li EM, Wang MR, Bi XG, Lin DC, Koeffler HP. Nat Commun. 2018 Sep 6;9(1):3619. doi: 10.1038/s41467-018-06081-9. PubMed
Histone deacetylase 2 is essential for LPS-induced inflammatory responses in macrophages. Wu C, Li A, Hu J, Kang J. Immunol Cell Biol. 2019 Jan;97(1):72-84. doi: 10.1111/imcb.12203. Epub 2018 Oct 31. PubMed
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Knockdown Of TRIM31 Enhances Colorectal Cancer Radiosensitivity By Inducing DNA Damage And Activating Apoptosis. Zhang H, Deng Y, Liang L, Shen L, Zhu J, Wang Y, Zhang J, Zhang Z. Onco Targets Ther. 2019 Oct 3;12:8179-8188. doi: 10.2147/OTT.S215769. eCollection 2019. PubMed
Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase alpha2. Gao J, Yuan J, Wang Q, Lei T, Shen X, Cui B, Zhang F, Ding W, Lu Z. Redox Biol. 2020 Jan;28:101345. doi: 10.1016/j.redox.2019.101345. Epub 2019 Oct 19. PubMed
Caspase-7 mediates caspase-1-induced apoptosis independently of Bid. Mahib MR, Hosojima S, Kushiyama H, Kinoshita T, Shiroishi T, Suda T, Tsuchiya K. Microbiol Immunol. 2020 Feb;64(2):143-152. doi: 10.1111/1348-0421.12756. Epub 2019 Nov 20. PubMed
NEXMIF/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function. Gilbert J, O'Connor M, Templet S, Moghaddam M, Di Via Ioschpe A, Sinclair A, Zhu LQ, Xu W, Man HY. J Neurosci. 2020 Jan 2;40(1):237-254. doi: 10.1523/JNEUROSCI.0222-19.2019. Epub 2019 Nov 8. PubMed
Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies. Tsai IC, Adams KA, Tzeng JA, Shennib O, Tan PL, Katsanis N. JCI Insight. 2019 Nov 14;4(22). pii: 130516. doi: 10.1172/jci.insight.130516. PubMed
Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage. Bolderson E, Burgess JT, Li J, Gandhi NS, Boucher D, Croft LV, Beard S, Plowman JJ, Suraweera A, Adams MN, Naqi A, Zhang SD, Sinclair DA, O'Byrne KJ, Richard DJ. Nat Commun. 2019 Dec 3;10(1):5501. doi: 10.1038/s41467-019-13167-5. PubMed
PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells. Foxall E, Staszowska A, Hirvonen LM, Georgouli M, Ciccioli M, Rimmer A, Williams L, Calle Y, Moreno VS, Cox S, Jones GE, Wells CM. Cell Rep. 2019 Dec 10;29(11):3385-3393.e6. doi: 10.1016/j.celrep.2019.11.016. PubMed
Molecular Tuning of the Axonal Mitochondrial Ca(2+) Uniporter Ensures Metabolic Flexibility of Neurotransmission. Ashrafi G, de Juan-Sanz J, Farrell RJ, Ryan TA. Neuron. 2019 Dec 10. pii: S0896-6273(19)30984-5. doi: 10.1016/j.neuron.2019.11.020. PubMed

Associated Plasmids

Transcriptome analysis-identified long noncoding RNA CRNDE in maintaining endothelial cell proliferation, migration, and tube formation. Moran M, Cheng X, Shihabudeen Haider Ali MS, Wase N, Nguyen N, Yang W, Zhang C, DiRusso C, Sun X. Sci Rep. 2019 Dec 20;9(1):19548. doi: 10.1038/s41598-019-56030-9. PubMed
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer. Zhang X, Ma N, Yao W, Li S, Ren Z. Cancer Cell Int. 2019 Dec 27;19:356. doi: 10.1186/s12935-019-1077-6. eCollection 2019. PubMed

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