Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Addgene is operating at a reduced capacity.

  • Pending order? We will email to confirm that your organization can accept shipments.
  • Conducting coronavirus or COVID-19 research? Email us at [email protected] with your order or deposit number so we can prioritize it.

Learn more about our current shipping status and COVID-19 resources.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected] Learn more

pLenti CMV Puro DEST (w118-1) Citations (76)

Plasmid Article: A versatile viral system for expression and depletion of proteins in mammalian cells.
Campeau E, Ruhl VE, Rodier F, Smith CL, Rahmberg BL, Fuss JO, Campisi J, Yaswen P, Cooper PK, Kaufman PD. PLoS One. 2009 Aug 6;4(8):e6529.
PubMed Journal

Articles Citing pLenti CMV Puro DEST (w118-1)

EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. White RE, Ramer PC, Naresh KN, Meixlsperger S, Pinaud L, Rooney C, Savoldo B, Coutinho R, Bodor C, Gribben J, Ibrahim HA, Bower M, Nourse JP, Gandhi MK, Middeldorp J, Cader FZ, Murray P, Munz C, Allday MJ. J Clin Invest. 2012 Apr;122(4):1487-502. doi: 10.1172/JCI58092. Epub 2012 Mar 12. PubMed
A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications. Thoma CR, Stroebel S, Rosch N, Calpe B, Krek W, Kelm JM. J Biomol Screen. 2013 Dec;18(10):1330-7. doi: 10.1177/1087057113499071. Epub 2013 Sep 30. PubMed
Par1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes. Slim CL, Lazaro-Dieguez F, Bijlard M, Toussaint MJ, de Bruin A, Du Q, Musch A, van Ijzendoorn SC. PLoS Biol. 2013 Dec;11(12):e1001739. doi: 10.1371/journal.pbio.1001739. Epub 2013 Dec 17. PubMed
PGC-1alpha and reactive oxygen species regulate human embryonic stem cell-derived cardiomyocyte function. Birket MJ, Casini S, Kosmidis G, Elliott DA, Gerencser AA, Baartscheer A, Schumacher C, Mastroberardino PG, Elefanty AG, Stanley EG, Mummery CL. Stem Cell Reports. 2013 Dec 12;1(6):560-74. doi: 10.1016/j.stemcr.2013.11.008. eCollection 2013. PubMed
Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN. Mol Cell. 2014 Feb 20;53(4):577-90. doi: 10.1016/j.molcel.2013.12.018. Epub 2014 Jan 23. PubMed
Placental lactogen is expressed but is not translated into protein in breast cancer. Tuttle TR, Hugo ER, Tong WS, Ben-Jonathan N. PLoS One. 2014 Jan 24;9(1):e87325. doi: 10.1371/journal.pone.0087325. eCollection 2014. PubMed
Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor. Leyton-Mange JS, Mills RW, Macri VS, Jang MY, Butte FN, Ellinor PT, Milan DJ. Stem Cell Reports. 2014 Feb 6;2(2):163-70. doi: 10.1016/j.stemcr.2014.01.003. eCollection 2014 Feb 11. PubMed
EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R. Dev Cell. 2014 Mar 10;28(5):483-96. doi: 10.1016/j.devcel.2014.01.021. Epub 2014 Feb 27. PubMed
Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation. Busch M, Schwindt H, Brandt A, Beier M, Gorldt N, Romaniuk P, Toska E, Roberts S, Royer HD, Royer-Pokora B. Hum Mol Genet. 2014 Aug 1;23(15):3958-74. doi: 10.1093/hmg/ddu111. Epub 2014 Mar 11. PubMed
The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection. Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell SA, Doxaki C, Kampranis SC, Kottakis F, Tsichlis PN. PLoS Pathog. 2014 May 15;10(5):e1004136. doi: 10.1371/journal.ppat.1004136. eCollection 2014 May. PubMed
LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer. He TY, Tsai LH, Huang CC, Chou MC, Lee H. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S703-10. doi: 10.1245/s10434-014-3824-1. Epub 2014 May 31. PubMed
Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity. Mulvihill MM, Benjamin DI, Ji X, Le Scolan E, Louie SM, Shieh A, Green M, Narasimhalu T, Morris PJ, Luo K, Nomura DK. Chem Biol. 2014 Jul 17;21(7):831-40. doi: 10.1016/j.chembiol.2014.05.008. Epub 2014 Jun 19. PubMed
ERbeta- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Monsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE. Mol Endocrinol. 2014 Aug;28(8):1304-15. doi: 10.1210/me.2013-1421. Epub 2014 Jul 3. PubMed
ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis. Siow D, Sunkara M, Dunn TM, Morris AJ, Wattenberg B. J Lipid Res. 2015 Apr;56(4):898-908. doi: 10.1194/jlr.M057539. Epub 2015 Feb 17. PubMed
WNT/beta-catenin signaling inhibits CBP-mediated RelA acetylation and expression of proinflammatory NF-kappaB target genes. Ma B, Fey M, Hottiger MO. J Cell Sci. 2015 Jul 15;128(14):2430-6. doi: 10.1242/jcs.168542. Epub 2015 May 28. PubMed
Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Mol Cancer. 2015 Jul 16;14:133. doi: 10.1186/s12943-015-0400-7. PubMed
Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer. Kwak EL, Ahronian LG, Siravegna G, Mussolin B, Godfrey JT, Clark JW, Blaszkowsky LS, Ryan DP, Lennerz JK, Iafrate AJ, Bardelli A, Hong TS, Corcoran RB. Cancer Discov. 2015 Dec;5(12):1271-81. doi: 10.1158/2159-8290.CD-15-0748. Epub 2015 Oct 2. PubMed
The adherens junctions control susceptibility to Staphylococcus aureus alpha-toxin. Popov LM, Marceau CD, Starkl PM, Lumb JH, Shah J, Guerrera D, Cooper RL, Merakou C, Bouley DM, Meng W, Kiyonari H, Takeichi M, Galli SJ, Bagnoli F, Citi S, Carette JE, Amieva MR. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14337-42. doi: 10.1073/pnas.1510265112. Epub 2015 Oct 21. PubMed
Autophagy positively regulates DNA damage recognition by nucleotide excision repair. Qiang L, Zhao B, Shah P, Sample A, Yang S, He YY. Autophagy. 2016;12(2):357-68. doi: 10.1080/15548627.2015.1110667. Epub 2015 Nov 13. PubMed
Restoration of the serum level of SERPINF1 does not correct the bone phenotype in Serpinf1 null mice. Rajagopal A, Homan EP, Joeng KS, Suzuki M, Bertin T, Cela R, Munivez E, Dawson B, Jiang MM, Gannon F, Crawford S, Lee BH. Mol Genet Metab. 2015 Dec 2. pii: S1096-7192(15)30085-8. doi: 10.1016/j.ymgme.2015.11.015. PubMed
MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains. Bijlard M, de Jonge JC, Klunder B, Nomden A, Hoekstra D, Baron W. PLoS One. 2016 May 12;11(5):e0155317. doi: 10.1371/journal.pone.0155317. eCollection 2016. PubMed
MYC Is a Crucial Mediator of TGFbeta-Induced Invasion in Basal Breast Cancer. Cichon MA, Moruzzi ME, Shqau TA, Miller E, Mehner C, Ethier SP, Copland JA, Radisky ES, Radisky DC. Cancer Res. 2016 Jun 15;76(12):3520-30. doi: 10.1158/0008-5472.CAN-15-3465. Epub 2016 Apr 13. PubMed
Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CW, Ma VW, Yip TT, Au JS, Hao Q, Cheung KH, Wu W, Li GR, Yue J. Autophagy. 2016 Aug 2;12(8):1340-54. doi: 10.1080/15548627.2016.1187365. Epub 2016 May 31. PubMed
Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration. Harrington KM, Clevenger CV. J Biol Chem. 2016 Oct 7;291(41):21388-21406. Epub 2016 Aug 3. PubMed
The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z. Genes Dev. 2016 Nov 15;30(22):2551-2564. Epub 2016 Dec 2. PubMed
Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche. Shahriari K, Shen F, Worrede-Mahdi A, Liu Q, Gong Y, Garcia FU, Fatatis A. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.436. PubMed
Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection. Perelman SS, Abrams ME, Eitson JL, Chen D, Jimenez A, Mettlen M, Schoggins JW, Alto NM. PLoS Pathog. 2016 Dec 21;12(12):e1006102. doi: 10.1371/journal.ppat.1006102. eCollection 2016 Dec. PubMed
Acquired Resistance to the Hsp90 Inhibitor, Ganetespib, in KRAS-Mutant NSCLC Is Mediated via Reactivation of the ERK-p90RSK-mTOR Signaling Network. Chatterjee S, Huang EH, Christie I, Kurland BF, Burns TF. Mol Cancer Ther. 2017 May;16(5):793-804. doi: 10.1158/1535-7163.MCT-16-0677. Epub 2017 Feb 6. PubMed
Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma. Barasch N, Gong X, Kwei KA, Varma S, Biscocho J, Qu K, Xiao N, Lipsick JS, Pelham RJ, West RB, Pollack JR. PLoS One. 2017 Feb 17;12(2):e0171265. doi: 10.1371/journal.pone.0171265. eCollection 2017. PubMed
Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation. Realegeno S, Puschnik AS, Kumar A, Goldsmith C, Burgado J, Sambhara S, Olson VA, Carroll D, Damon I, Hirata T, Kinoshita T, Carette JE, Satheshkumar PS. J Virol. 2017 May 12;91(11). pii: JVI.00011-17. doi: 10.1128/JVI.00011-17. Print 2017 Jun 1. PubMed
Reactivation of the p90RSK-CDC25C pathway leads to bypass of the ganetespib induced G2/M arrest and mediates acquired resistance to ganetespib in KRAS mutant NSCLC. Chatterjee S, Huang EH, Christie I, Burns TF. Mol Cancer Ther. 2017 May 31. pii: molcanther.0114.2017. doi: 10.1158/1535-7163.MCT-17-0114. PubMed
AAV serotypes have distinctive interactions with domains of the cellular receptor AAVR. Pillay S, Zou W, Cheng F, Puschnik AS, Meyer NL, Ganaie SS, Deng X, Wosen JE, Davulcu O, Yan Z, Engelhardt JF, Brown KE, Chapman MS, Qiu J, Carette JE. J Virol. 2017 Jul 5. pii: JVI.00391-17. doi: 10.1128/JVI.00391-17. PubMed
Optimization of proximity ligation assay (PLA) for detection of protein interactions and fusion proteins in non-adherent cells: application to pre-B lymphocytes. Debaize L, Jakobczyk H, Rio AG, Gandemer V, Troadec MB. Mol Cytogenet. 2017 Jul 20;10:27. doi: 10.1186/s13039-017-0328-2. eCollection 2017. PubMed
Lysine-52 stabilizes the MYC oncoprotein through an SCF(Fbxw7)-independent mechanism. De Melo J, Kim SS, Lourenco C, Penn LZ. Oncogene. 2017 Dec 7;36(49):6815-6822. doi: 10.1038/onc.2017.268. Epub 2017 Aug 14. PubMed
Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. Bosse KR, Raman P, Zhu Z, Lane M, Martinez D, Heitzeneder S, Rathi KS, Kendsersky NM, Randall M, Donovan L, Morrissy S, Sussman RT, Zhelev DV, Feng Y, Wang Y, Hwang J, Lopez G, Harenza JL, Wei JS, Pawel B, Bhatti T, Santi M, Ganguly A, Khan J, Marra MA, Taylor MD, Dimitrov DS, Mackall CL, Maris JM. Cancer Cell. 2017 Sep 11;32(3):295-309.e12. doi: 10.1016/j.ccell.2017.08.003. PubMed
A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b. Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT. Sci Rep. 2017 Sep 19;7(1):11839. doi: 10.1038/s41598-017-11791-z. PubMed

Associated Plasmids

Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Ehrnstrom B, Beckwith KS, Yurchenko M, Moen SH, Kojen JF, Lentini G, Teti G, Damas JK, Espevik T, Stenvik J. Front Immunol. 2017 Oct 3;8:1243. doi: 10.3389/fimmu.2017.01243. eCollection 2017. PubMed
Fluorescently-tagged human eIF3 for single-molecule spectroscopy. Johnson AG, Petrov AN, Fuchs G, Majzoub K, Grosely R, Choi J, Puglisi JD. Nucleic Acids Res. 2018 Jan 25;46(2):e8. doi: 10.1093/nar/gkx1050. PubMed
Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer. Strickler JH, Loree JM, Ahronian LG, Parikh AR, Niedzwiecki D, Pereira AAL, McKinney M, Korn WM, Atreya CE, Banks KC, Nagy RJ, Meric-Bernstam F, Lanman RB, Talasaz A, Tsigelny IF, Corcoran RB, Kopetz S. Cancer Discov. 2018 Feb;8(2):164-173. doi: 10.1158/2159-8290.CD-17-1009. Epub 2017 Dec 1. PubMed
Defective STIM-mediated store operated Ca(2+) entry in hepatocytes leads to metabolic dysfunction in obesity. Arruda AP, Pers BM, Parlakgul G, Guney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS. Elife. 2017 Dec 15;6. pii: 29968. doi: 10.7554/eLife.29968. PubMed
AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S. Nat Commun. 2018 Apr 12;9(1):1411. doi: 10.1038/s41467-018-03771-2. PubMed
A rare variant in MLKL confers susceptibility to ApoE varepsilon4-negative Alzheimer's disease in Hong Kong Chinese population. Wang B, Bao S, Zhang Z, Zhou X, Wang J, Fan Y, Zhang Y, Li Y, Chen L, Jia Y, Li J, Li M, Zheng W, Mu N, Wang L, Yu Z, Wong DSM, Zhang Y, Kwan J, Ka-Fung Mak H, Ambalavanan A, Zhou S, Cai W, Zheng J, Huang S, Rouleau GA, Yang W, Rogaeva E, Ma X, St George-Hyslop P, Chu LW, Song YQ. Neurobiol Aging. 2018 Aug;68:160.e1-160.e7. doi: 10.1016/j.neurobiolaging.2018.03.006. Epub 2018 Mar 10. PubMed
Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair. Shah P, Zhao B, Qiang L, He YY. Nucleic Acids Res. 2018 Jun 1;46(10):5050-5060. doi: 10.1093/nar/gky239. PubMed
CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in infected T-cell cultures. Ophinni Y, Inoue M, Kotaki T, Kameoka M. Sci Rep. 2018 May 17;8(1):7784. doi: 10.1038/s41598-018-26190-1. PubMed
Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. Zhang Y, Paikari A, Sumazin P, Ginter Summarell CC, Crosby JR, Boerwinkle E, Weiss MJ, Sheehan VA. Blood. 2018 Jul 19;132(3):321-333. doi: 10.1182/blood-2017-11-814335. Epub 2018 Jun 8. PubMed
The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage. Menoni H, Wienholz F, Theil AF, Janssens RC, Lans H, Campalans A, Radicella JP, Marteijn JA, Vermeulen W. Nucleic Acids Res. 2018 Sep 6;46(15):7747-7756. doi: 10.1093/nar/gky579. PubMed
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc(-) Activity. Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, Lotze MT, Zeh HJ, Kang R, Tang D. Curr Biol. 2018 Aug 6;28(15):2388-2399.e5. doi: 10.1016/j.cub.2018.05.094. Epub 2018 Jul 26. PubMed
Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease. Paakkola T, Salokas K, Miinalainen I, Lehtonen S, Manninen A, Kaakinen M, Ruddock LW, Varjosalo M, Kaarteenaho R, Uusimaa J, Hinttala R. Hum Mol Genet. 2018 Dec 15;27(24):4288-4302. doi: 10.1093/hmg/ddy298. PubMed
Heterozygous WNT1 variant causing a variable bone phenotype. Alhamdi S, Lee YC, Chowdhury S, Byers PH, Gottschalk M, Taft RJ, Joeng KS, Lee BH, Bird LM. Am J Med Genet A. 2018 Nov;176(11):2419-2424. doi: 10.1002/ajmg.a.40347. Epub 2018 Sep 24. PubMed
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2. PubMed
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia. Aries IM, Bodaar K, Karim SA, Chonghaile TN, Hinze L, Burns MA, Pfirrmann M, Degar J, Landrigan JT, Balbach S, Peirs S, Menten B, Isenhart R, Stevenson KE, Neuberg DS, Devidas M, Loh ML, Hunger SP, Teachey DT, Rabin KR, Winter SS, Dunsmore KP, Wood BL, Silverman LB, Sallan SE, Van Vlierberghe P, Orkin SH, Knoechel B, Letai AG, Gutierrez A. J Exp Med. 2018 Nov 7. pii: jem.20180570. doi: 10.1084/jem.20180570. PubMed

Associated Plasmids

Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio AG, Serandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zornig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB. Nucleic Acids Res. 2018 Nov 30;46(21):11214-11228. doi: 10.1093/nar/gky756. PubMed
Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen. Petrova E, Gracias S, Beauclair G, Tangy F, Jouvenet N. Viruses. 2019 Jan 15;11(1). pii: v11010068. doi: 10.3390/v11010068. PubMed
ONECUT2 is a driver of neuroendocrine prostate cancer. Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A, Beltran H, Wang Y, He HH. Nat Commun. 2019 Jan 17;10(1):278. doi: 10.1038/s41467-018-08133-6. PubMed
A cytosolic chaperone complex controls folding and degradation of type III CD38. Wu Y, Zhang J, Fang L, Lee HC, Zhao YJ. J Biol Chem. 2019 Mar 15;294(11):4247-4258. doi: 10.1074/jbc.RA118.005844. Epub 2019 Jan 22. PubMed
FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER. Wienholz F, Zhou D, Turkyilmaz Y, Schwertman P, Tresini M, Pines A, van Toorn M, Bezstarosti K, Demmers JAA, Marteijn JA. Nucleic Acids Res. 2019 May 7;47(8):4011-4025. doi: 10.1093/nar/gkz055. PubMed
A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cao JY, Poddar A, Magtanong L, Lumb JH, Mileur TR, Reid MA, Dovey CM, Wang J, Locasale JW, Stone E, Cole SPC, Carette JE, Dixon SJ. Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. doi: 10.1016/j.celrep.2019.01.043. PubMed
TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma. Zhang J, Liu P, Tao J, Wang P, Zhang Y, Song X, Che L, Sumazin P, Ribback S, Kiss A, Schaff Z, Cigliano A, Dombrowski F, Cossu C, Pascale RM, Calvisi DF, Monga SP, Chen X. Am J Pathol. 2019 May;189(5):1077-1090. doi: 10.1016/j.ajpath.2019.01.016. Epub 2019 Feb 19. PubMed
Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis. Li J, Wada S, Weaver LK, Biswas C, Behrens EM, Arany Z. JCI Insight. 2019 Mar 7;5. pii: 126939. doi: 10.1172/jci.insight.126939. PubMed
Development of a Synthetic 3-ketosteroid Delta(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE. Sci Rep. 2019 Apr 12;9(1):5969. doi: 10.1038/s41598-019-42046-8. PubMed
Critical role for Piccolo in synaptic vesicle retrieval. Ackermann F, Schink KO, Bruns C, Izsvak Z, Hamra FK, Rosenmund C, Garner CC. Elife. 2019 May 10;8. pii: 46629. doi: 10.7554/eLife.46629. PubMed
Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer. Ni Y, Schmidt KR, Werner BA, Koenig JK, Guldner IH, Schnepp PM, Tan X, Jiang L, Host M, Sun L, Howe EN, Wu J, Littlepage LE, Nakshatri H, Zhang S. Nat Commun. 2019 Jun 28;10(1):2860. doi: 10.1038/s41467-019-10743-7. PubMed
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M, Patil Y, Newey A, Mansukhani S, Davies MN, Furness A, Sclafani F, Peckitt C, Jimenez M, Kouvelakis K, Ranftl R, Begum R, Rana I, Thomas J, Bryant A, Quezada S, Wotherspoon A, Khan N, Fotiadis N, Marafioti T, Powles T, Lise S, Calvo F, Guettler S, von Loga K, Rao S, Watkins D, Starling N, Chau I, Sadanandam A, Cunningham D, Gerlinger M. Cancer Cell. 2019 Jul 8;36(1):35-50.e9. doi: 10.1016/j.ccell.2019.05.013. PubMed
A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology. Birket MJ, Raibaud S, Lettieri M, Adamson AD, Letang V, Cervello P, Redon N, Ret G, Viale S, Wang B, Biton B, Guillemot JC, Mikol V, Leonard JP, Hanley NA, Orsini C, Itier JM. Stem Cell Reports. 2019 Aug 13;13(2):380-393. doi: 10.1016/j.stemcr.2019.07.004. Epub 2019 Aug 1. PubMed
Notch3 promotes prostate cancer-induced bone lesion development via MMP-3. Ganguly SS, Hostetter G, Tang L, Frank SB, Saboda K, Mehra R, Wang L, Li X, Keller ET, Miranti CK. Oncogene. 2020 Jan;39(1):204-218. doi: 10.1038/s41388-019-0977-1. Epub 2019 Aug 29. PubMed
The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins. Ngo AM, Shurtleff MJ, Popova KD, Kulsuptrakul J, Weissman JS, Puschnik AS. Elife. 2019 Sep 13;8. pii: 48469. doi: 10.7554/eLife.48469. PubMed
MicroRNA-338-5p reverses chemoresistance and inhibits invasion of esophageal squamous cell carcinoma cells by targeting Id-1. Han L, Cui D, Li B, Xu WW, Lam AKY, Chan KT, Zhu Y, Lee NPY, Law SYK, Guan XY, Qin YR, Chan KW, Ma S, Tsao SW, Cheung ALM. Cancer Sci. 2019 Dec;110(12):3677-3688. doi: 10.1111/cas.14220. Epub 2019 Nov 17. PubMed
Beclin1-mediated ferroptosis activation is associated with isoflurane-induced toxicity in SH-SY5Y neuroblastoma cells. Liu R, Li X, Zhao G. Acta Biochim Biophys Sin (Shanghai). 2019 Nov 18;51(11):1134-1141. doi: 10.1093/abbs/gmz104. PubMed
Phase separation-deficient TDP43 remains functional in splicing. Schmidt HB, Barreau A, Rohatgi R. Nat Commun. 2019 Oct 25;10(1):4890. doi: 10.1038/s41467-019-12740-2. PubMed
MX 2 is a novel regulator of cell cycle in melanoma cells. Juraleviciute M, Pozniak J, Nsengimana J, Harland M, Randerson-Moor J, Wernhoff P, Bassarova A, Oy GF, Troen G, Florenes VA, Bishop DT, Herlyn M, Newton-Bishop J, Slipicevic A. Pigment Cell Melanoma Res. 2019 Oct 29. doi: 10.1111/pcmr.12837. PubMed
Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. Pouliot GP, Degar J, Hinze L, Kochupurakkal B, Vo CD, Burns MA, Moreau L, Ganesa C, Roderick J, Peirs S, Menten B, Loh ML, Hunger SP, Silverman LB, Harris MH, Stevenson KE, Weinstock DM, Weng AP, Van Vlierberghe P, D'Andrea AD, Gutierrez A. PLoS One. 2019 Nov 13;14(11):e0221288. doi: 10.1371/journal.pone.0221288. eCollection 2019. PubMed
Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies. Sung YC, Jin PR, Chu LA, Hsu FF, Wang MR, Chang CC, Chiou SJ, Qiu JT, Gao DY, Lin CC, Chen YS, Hsu YC, Wang J, Wang FN, Yu PL, Chiang AS, Wu AY, Ko JJ, Lai CP, Lu TT, Chen Y. Nat Nanotechnol. 2019 Dec;14(12):1160-1169. doi: 10.1038/s41565-019-0570-3. Epub 2019 Nov 18. PubMed
A molecular mechanism underlying genotype-specific intrahepatic cholestasis resulting from MYO5B mutations. Overeem AW, Li Q, Qiu YL, Carton-Garcia F, Leng C, Klappe K, Dronkers J, Hsiao NH, Wang JS, Arango D, van IJzendoorn SCD. Hepatology. 2019 Nov 21. doi: 10.1002/hep.31002. PubMed
cMyc and ERK activity are associated with resistance to ALK inhibitory treatment in glioblastoma. Berberich A, Schmitt LM, Pusch S, Hielscher T, Rubmann P, Hucke N, Latzer P, Hessling B, Lemke D, Kessler T, Platten M, Wick W. J Neurooncol. 2020 Jan;146(1):9-23. doi: 10.1007/s11060-019-03348-z. Epub 2019 Nov 28. PubMed
HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1. Santos-Barriopedro I, Li Y, Bahl S, Seto E. Genes Cancer. 2019;10(5-6):119-133. doi: 10.18632/genesandcancer.197. PubMed
APOBEC3A is a prominent cytidine deaminase in breast cancer. Cortez LM, Brown AL, Dennis MA, Collins CD, Brown AJ, Mitchell D, Mertz TM, Roberts SA. PLoS Genet. 2019 Dec 16;15(12):e1008545. doi: 10.1371/journal.pgen.1008545. eCollection 2019 Dec. PubMed

If you have published an article using this plasmid, please email us at [email protected] to have your article added to this page.