pHAGE EF1α dCas9-VP64 Citations (20)
Originally described in: Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells.Kearns NA, Genga RM, Enuameh MS, Garber M, Wolfe SA, Maehr R Development. 2014 Jan;141(1):219-23. doi: 10.1242/dev.103341. PubMed Journal
Articles Citing pHAGE EF1α dCas9-VP64
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Transcriptional Regulation with CRISPR/Cas9 Effectors in Mammalian Cells.
Pham H, Kearns NA, Maehr R.
Methods Mol Biol. 2016;1358:43-57. doi: 10.1007/978-1-4939-3067-8_3.
PubMed
Associated Plasmids |
| CRISPR/dCas9-mediated Transcriptional Inhibition Ameliorates the Epigenetic Dysregulation at D4Z4 and Represses DUX4-fl in FSH Muscular Dystrophy. Himeda CL, Jones TI, Jones PL. Mol Ther. 2015 Nov 3. doi: 10.1038/mt.2015.200. PubMed |
| Potent and Targeted Activation of Latent HIV-1 Using the CRISPR/dCas9 Activator Complex. Saayman SM, Lazar DC, Scott TA, Hart JR, Takahashi M, Burnett JC, Planelles V, Morris KV, Weinberg MS. Mol Ther. 2015 Nov 19. doi: 10.1038/mt.2015.202. PubMed |
| Quantification of dopaminergic neuron differentiation and neurotoxicity via a genetic reporter. Cui J, Rothstein M, Bennett T, Zhang P, Xia N, Reijo Pera RA. Sci Rep. 2016 Apr 28;6:25181. doi: 10.1038/srep25181. PubMed |
| Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells. Song J, Cano Rodriguez D, Winkle M, Gjaltema RA, Goubert D, Jurkowski TP, Heijink IH, Rots MG, Hylkema MN. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 23:ajplung.00059.2016. doi: 10.1152/ajplung.00059.2016. PubMed |
| A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Good CR, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, Issa JJ. Nucleic Acids Res. 2017 May 22. doi: 10.1093/nar/gkx435. PubMed |
| Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes. Bischoff FC, Werner A, John D, Boeckel JN, Melissari MT, Grote P, Glaser SF, Demolli S, Uchida S, Michalik KM, Meder B, Katus HA, Haas J, Chen W, Pullamsetti SS, Seeger W, Zeiher AM, Dimmeler S, Zehendner CM. Circ Res. 2017 Aug 4;121(4):368-375. doi: 10.1161/CIRCRESAHA.116.310531. Epub 2017 Jun 13. PubMed |
Establishment of Cell Lines Stably Expressing dCas9-Fusions to Address Kinetics of Epigenetic Editing.
Goubert D, Koncz M, Kiss A, Rots MG.
Methods Mol Biol. 2018;1767:395-415. doi: 10.1007/978-1-4939-7774-1_22.
PubMed
Associated Plasmids |
Regulation of Neuroregeneration by Long Noncoding RNAs.
Perry RB, Hezroni H, Goldrich MJ, Ulitsky I.
Mol Cell. 2018 Nov 1;72(3):553-567.e5. doi: 10.1016/j.molcel.2018.09.021. Epub 2018 Oct 25.
PubMed
Associated Plasmids |
| Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR. Rankin CR, Treger J, Faure-Kumar E, Benhammou J, Anisman-Posner D, Bollinger AE, Pothoulakis C, Padua DM. J Vis Exp. 2019 Mar 1;(145). doi: 10.3791/59233. PubMed |
| CRISPR-based Activation of Endogenous Neurotrophic Genes in Adipose Stem Cell Sheets to Stimulate Peripheral Nerve Regeneration. Hsu MN, Liao HT, Truong VA, Huang KL, Yu FJ, Chen HH, Nguyen TKN, Makarevich P, Parfyonova Y, Hu YC. Theranostics. 2019 Aug 14;9(21):6099-6111. doi: 10.7150/thno.36790. eCollection 2019. PubMed |
| The IBD-associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation. Rankin CR, Shao L, Elliott J, Rowe L, Patel A, Videlock E, Benhammou JN, Sauk JS, Ather N, Corson M, Alipour O, Gulati A, Pothoulakis C, Padua DM. Am J Physiol Gastrointest Liver Physiol. 2020 Jan 1;318(1):G34-G40. doi: 10.1152/ajpgi.00232.2019. Epub 2019 Sep 23. PubMed |
| A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Stojic L, Lun ATL, Mascalchi P, Ernst C, Redmond AM, Mangei J, Barr AR, Bousgouni V, Bakal C, Marioni JC, Odom DT, Gergely F. Nat Commun. 2020 Apr 15;11(1):1851. doi: 10.1038/s41467-020-14978-7. PubMed |
| Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling. Dibitetto D, Sims JR, Ascencao CFR, Feng K, Kim D, Oberly S, Freire R, Smolka MB. NAR Cancer. 2020 Jun;2(2):zcaa006. doi: 10.1093/narcan/zcaa006. Epub 2020 May 1. PubMed |
| Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells. Chang L, Li M, Shao S, Li C, Ai S, Xue B, Hou Y, Zhang Y, Li R, Fan X, He A, Li C, Sun Y. Protein Cell. 2022 Apr;13(4):258-280. doi: 10.1007/s13238-020-00794-8. Epub 2020 Nov 5. PubMed |
| Suppression of the NTS-CPS1 regulatory axis by AFF1 in lung adenocarcinoma cells. Yue J, Dai Q, Hao S, Zhu S, Liu X, Tang Z, Li M, Fang H, Lin C, Luo Z. J Biol Chem. 2021 Jan-Jun;296:100319. doi: 10.1016/j.jbc.2021.100319. Epub 2021 Jan 22. PubMed |
| A protocol for CRISPR-mediated activation and repression of human endogenous retroviruses in human pluripotent stem cells. Nair VP, Mayer J, Vincendeau M. STAR Protoc. 2022 Apr 12;3(2):101281. doi: 10.1016/j.xpro.2022.101281. eCollection 2022 Jun 17. PubMed |
| Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2. Oo JA, Palfi K, Warwick T, Wittig I, Prieto-Garcia C, Matkovic V, Tomaskovic I, Boos F, Izquierdo Ponce J, Teichmann T, Petriukov K, Haydar S, Maegdefessel L, Wu Z, Pham MD, Krishnan J, Baker AH, Gunther S, Ulrich HD, Dikic I, Leisegang MS, Brandes RP. Cell Rep. 2022 Nov 15;41(7):111670. doi: 10.1016/j.celrep.2022.111670. PubMed |
| Functional Validation of the Putative Oncogenic Activity of PLAU. Sarno F, Goubert D, Logie E, Rutten MGS, Koncz M, Deben C, Niemarkt AE, Altucci L, Verschure PJ, Kiss A, Berghe WV, Rots MG. Biomedicines. 2022 Dec 30;11(1):102. doi: 10.3390/biomedicines11010102. PubMed |
| GDNF-RET signaling and EGR1 form a positive feedback loop that promotes tamoxifen resistance via cyclin D1. Marks BA, Pipia IM, Mukai C, Horibata S, Rice EJ, Danko CG, Coonrod SA. BMC Cancer. 2023 Feb 10;23(1):138. doi: 10.1186/s12885-023-10559-1. PubMed |
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