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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
Nature. 2010 Nov 24. ():.
PubMed Article

Plasmids from Article

ID Plasmid  
23353pDONR223-NME1-NME2
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23354pDONR223-CRKL
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23355pDONR223-CSNK1A1
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23356pDONR223-CCL4
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23358pDONR223-C1orf57
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23359pDONR223-CSNK2B
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23360pDONR223-PRKAB1
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23361pDONR223-LOC389599
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23364pDONR223-CIB1
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23367pDONR223-FLJ25006
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23368pDONR223-CDK3
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23369pDONR223-PION
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23370pDONR223-STK19
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23372pDONR223-LOC442075
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23373pDONR223-LOC390877
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23374pDONR223-AURKC
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23375pDONR223-FLJ23356
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23376pDONR223-PRKAR1B
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23377pDONR223-FLJ40852
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23378pDONR223-SGK2
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23380pDONR223-GUK1
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23381pDONR223-DCK
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23382pDONR223-CDKL4
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23383pDONR223-PRKX
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23384pDONR223-PANK3
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23385pDONR223-PHKG1
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23386pDONR223-CIB4
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23387pDONR223-PKDCC
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23389pDONR223-CDKL1
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23390pDONR223-DAPK2
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23391pDONR223-LOC649288
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23392pDONR223-NME2
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23393pDONR223-ITGB1BP3
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23394pDONR223-LOC652799
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23395pDONR223-NEK7
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23396pDONR223-SLAMF6
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23397pDONR223-TSSK2
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23399pDONR223-BMP2KL
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23400pDONR223-CSNK1G3
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23401pDONR223-ACVR2B
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23402pDONR223-GRK7
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23404pDONR223-MARK2
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23405pDONR223-SNRK
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23406pDONR223-MAP2K1
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23407pDONR223-PLXNB2
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23408pDONR223-CAMK2A
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23409pDONR223-CAMK2G
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23410pDONR223-BRD3
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23411pDONR223-MPP7
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23412pDONR223-IRAK2
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23413pDONR223-PRKG1
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23414pDONR223-PFKFB1
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23415pDONR223-IPPK
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23416pDONR223-MPP6
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23417pDONR223-MPP4
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23418pDONR223-NEK8
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23419pDONR223-PANK4
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23420pDONR223-MAPK8
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23421pDONR223-CDKL2
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23422pDONR223-CAMKK2
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23423pDONR223-BMP2K
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23424pDONR223-PRKCQ
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23426pDONR223-MAPKAPK2
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23427pDONR223-PGK1
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23428pDONR223-CHKA
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23429pDONR223-CDC2L6
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23431pDONR223-MPP3
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23432pDONR223-BRSK2
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23433pDONR223-UHMK1
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23434pDONR223-NEK5
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23435pDONR223-PRKG2
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23436pDONR223-DAPK3
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23437pDONR223-NEK10
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23438pDONR223-TGFBR1
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23439pDONR223-PAK3
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23440pDONR223-SRPK3
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23441pDONR223-MAPK4
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23442pDONR223-RIPK1
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23443pDONR223-KSR
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23445pDONR223-GTF2H1
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23446pDONR223-RKHD3
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23447pDONR223-MPP5
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23448pDONR223-GNE
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23449pDONR223-IHPK3
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23450pDONR223-PIP5K2C
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23451pDONR223-DLG3
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23452pDONR223-PRKR
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23453pDONR223-AMHR2
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23454pDONR223-MAP3K2
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23455pDONR223-BRD4
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23456pDONR223-MAST2
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23457pDONR223-PIK3C3
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23458pDONR223-SCYL2
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23459pDONR223-NEK9
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23460pDONR223-RPS6KC1
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23465pDONR223-PRPF4B
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23466pDONR223-PIK3CA
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23467pDONR223-HIPK3
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23468pDONR223-ALDH18A1
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23469pDONR223-TNNI3K
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23470pDONR223-CASK
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23471pDONR223-PHKA1
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23472pDONR223-GSG2
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23473pDONR223-MAP3K11
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23474pDONR223-ULK2
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23475pDONR223-DKFZp761P0423
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23476pDONR223-TRPM7
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23477pDONR223-DGKB
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23478pDONR223-TGFBR3
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23479pDONR223-NPR2
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23480pDONR223-DAPK1
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23481pDONR223-HIPK2
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23482pDONR223-CARD11
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23483pDONR223-PIK3C2G
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23484pDONR223-MAP4K1
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23485pDONR223-LATS2
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23486pDONR223-MAP4K4
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23487pDONR223-DGKK
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23488pDONR223-PIK3R4
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23489pDONR223-LRGUK
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23490pDONR223-PRKD2
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23491pDONR223-ERN1
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23492pDONR223-KIAA2002
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23493pDONR223-ALPK2
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23495pDONR223-PRKACA
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23496pDONR223-VRK1
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23497pDONR223-NEK4
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23498pDONR223-MAPK1
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23499pDONR223-MAP3K15
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23500pDONR223-PRKD1
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23501pDONR223-KSR2
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23503pDONR223-PI4KII
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23504pDONR223-PINK1
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23506pDONR223-PRKY
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23507pDONR223-PI4K2B
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23508pDONR223-DKFZp434B1231
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23509pDONR223-MAPK3
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23510pDONR223-GSK3A
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23511pDONR223-LIMK1
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23513pDONR223-LOC648152
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23514pDONR223-PSKH1
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23515pDONR223-MASTL
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23517pDONR223-MAP3K5
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23518pDONR223-PLXNA3
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23519pDONR223-TPR
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23520pDONR223-LRRK2
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23521pDONR223-LRPPRC
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23522pDONR223-MINK1
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23523pDONR223-MAGI1
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23524pDONR223-MYO3B
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23525pDONR223-CDC42BPG
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23526pDONR223-PHKA2
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23527pDONR223-RPS6KA3
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23529pDONR223-DGKG
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23530pDONR223-RPS6KA2
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23531pDONR223-MKNK1
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23532pDONR223-AURKA
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23533pDONR223-RPS6KB2
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23534pDONR223-VRK2
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23535pDONR223-RIOK2
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23536pDONR223-IKBKE
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23537pDONR223-RIOK3
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23538pDONR223-MAP3K8
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23539pDONR223-AKT3
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23540pDONR223-RPS6KA6
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23541pDONR223-PIK4CA
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23542pDONR223-PIK3CB
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23543pDONR223-PAK1
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23544pDONR223-CAMK1
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23545pDONR223-LOC340371
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23546pDONR223-LOC91807
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23547pDONR223-MORN2
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23549pDONR223-PRKAG3
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23550pDONR223-PRKCA
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23551pDONR223-PRKCE
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23552pDONR223-CCL2
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23553pDONR223-TSSK3
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23554pDONR223-GK5
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23555pDONR223-MAP2K2
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23556pDONR223-PDK3
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23557pDONR223-FLJ10986
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23558pDONR223-IHPK1
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23559pDONR223-NUP62
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23560pDONR223-FASTKD5
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23561pDONR223-RP6-213H19.1
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23562pDONR223-NME6
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23563pDONR223-DTYMK
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23564pDONR223-AK3L1
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23565pDONR223-STK16
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23566pDONR223-SH3BP5L
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23567pDONR223-ACVR1B
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23568pDONR223-NRBP
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23569pDONR223-COL4A3BP
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23571pDONR223-ASCIZ
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23572pDONR223-PNCK
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23573pDONR223-NME1
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23574pDONR223-NME3
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23575pDONR223-AK1
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23577pDONR223-PDK4
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23578pDONR223-AGK
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23579pDONR223-SH3BP5
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23580pDONR223-PRKD3
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23581pDONR223-PAPSS2
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23582pDONR223-SRPK1
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23583pDONR223-PANK2
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23584pDONR223-NME4
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23585pDONR223-DCAKD
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23586pDONR223-KHK
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23587pDONR223-PIM2
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23588pDONR223-PRPS1
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23589pDONR223-TRIB2
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23590pDONR223-CD2
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23591pDONR223-PDGFRL
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23592pDONR223-KIAA0999
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23595pDONR223-STK24
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23596pDONR223-MGC42105
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23597pDONR223-BRSK1
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23598pDONR223-C9orf98
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23599pDONR223-SGK3
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23600pDONR223-FGFRL1
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23601pDONR223-PI4KAP2
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23602pDONR223-TXNDC3
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23603pDONR223-FASTKD1
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23604pDONR223-DCAMKL2
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23605pDONR223-FASTKD2
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23606pDONR223-HSPB8
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23607pDONR223-TRIM27
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23608pDONR223-PLXNA4B
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23609pDONR223-CABC1
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23610pDONR223-MGC16169
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23611pDONR223-MAP4K5
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23612pDONR223-BUB1
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23613pDONR223-HKDC1
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23614pDONR223-SCYL1
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23615pDONR223-ACVR1C
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23616pDONR223-YSK4
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23617pDONR223-SNX16
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23618pDONR223-BMPR1A
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23619pDONR223-ARSG
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23620pDONR223-FXN
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23621pDONR223-FN3K
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23622pDONR223-PRPS2
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23623pDONR223-TGFBR2
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23624pDONR223-MAK
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23625pDONR223-PGK2
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23626pDONR223-MAP3K12
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23627pDONR223-IRAK3
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23628pDONR223-CDKL3
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23629pDONR223-TLK2
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23630pDONR223-ALPK1
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23631pDONR223-PIP5KL1
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23632pDONR223-ALS2CR7
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23633pDONR223-LYK5
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23634pDONR223-ETNK1
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23635pDONR223-DYRK3
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23636pDONR223-RP2
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23637pDONR223-MAPKAPK5
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23638pDONR223-BMPR1B
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23639pDONR223-XYLB
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23640pDONR223-PRKCG
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23641pDONR223-RPS6KA4
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23642pDONR223-NLK
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23643pDONR223-SH3BP4
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23644pDONR223-MAP4K2
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23645pDONR223-RAGE
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23646pDONR223-ULK3
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23647pDONR223-PRKAB2
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23648pDONR223-NJMU-R1
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23649pDONR223-MAPK10
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23650pDONR223-ADCK1
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23651pDONR223-PTK9
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23652pDONR223-CDK10
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23653pDONR223-GLYCTK
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23654pDONR223-ACVR2A
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23655pDONR223-PAK2
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23656pDONR223-MYLK2
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23657pDONR223-MOS
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23658pDONR223-NEK2
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23659pDONR223-TPK1
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23660pDONR223-COASY
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23662pDONR223-RIPK5
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23664pDONR223-MAP4K3
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23665pDONR223-LATS1
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23666pDONR223-IPMK
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23667pDONR223-PRKAR2B
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23668pDONR223-PFKFB3
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23669pDONR223-BMPR2
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23670pDONR223-WNK1
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23671pDONR223-PRKAA2
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23672pDONR223-PKLR
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23673pDONR223-MPP2
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23674pDONR223-EXOSC10
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23675pDONR223-XRCC6BP1
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23676pDONR223-AK2
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23677pDONR223-TRIB3
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23678pDONR223-CSNK2A1
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23679pDONR223-FN3KRP
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23680pDONR223-SCYL3
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23681pDONR223-RBKS
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23682pDONR223-AURKB
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23684pDONR223-FUK
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23685pDONR223-CLK2
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23686pDONR223-RPS6KB1
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23687pDONR223-VRK3
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23688pDONR223-CDK6
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23689pDONR223-PRKAG2
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23690pDONR223-DYRK2
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23691pDONR223-PLK2
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23692pDONR223-PIM1
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23693pDONR223-MAP3K7
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23694pDONR223-MAP2K1IP1
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23695pDONR223-TESK2
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23696pDONR223-PIK3R1
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23697pDONR223-MAPK15
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23698pDONR223-RFK
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23699pDONR223-CDK5
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23700pDONR223-TWF2
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23701pDONR223-CDK9
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23702pDONR223-NME7
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23703pDONR223-MVK
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23704pDONR223-SPHK1
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23705pDONR223-CSNK1G2
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23706pDONR223-CKMT1A
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23708pDONR223-SGK
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23709pDONR223-ZAK
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23710pDONR223-PCTK3
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23711pDONR223-ADCK4
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23712pDONR223-FASTK
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23713pDONR223-PAK4
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23714pDONR223-SPHK2
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23715pDONR223-PCK2
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23716pDONR223-MARK3
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23717pDONR223-CCRK
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23718pDONR223-PRKAG1
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23719pDONR223-MAPK12
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23720pDONR223-STK32C
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23721pDONR223-STK17B
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23722pDONR223-ADCK2
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23723pDONR223-PXK
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23724pDONR223-PRKCZ
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23725pDONR223-ARAF
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23726pDONR223-EEF2K
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23727pDONR223-TLK1
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23728pDONR223-PFKM
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23729pDONR223-PFKL
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23730pDONR223-HK1
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23731pDONR223-HK3
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23732pDONR223-MAP3K14
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23734pDONR223-CALM2
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23735pDONR223-MKNK2
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23736pDONR223-TK1
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23737pDONR223-CSNK1G1
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23738pDONR223-PDIK1L
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23739pDONR223-MAPK13
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23740pDONR223-TSSK1
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23741pDONR223-PRKAR1A
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23742pDONR223-CKB
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23743pDONR223-GALK1
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23744pDONR223-PIP5K2A
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23745pDONR223-PHKG2
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23746pDONR223-CKMT2
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23747pDONR223-NADK
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23748pDONR223-GALK2
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23749pDONR223-IRAK4
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23750pDONR223-GCK
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23751pDONR223-MPP1
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23752pDONR223-AKT1
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23753pDONR223-CLK3
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23754pDONR223-PCTK1
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23755pDONR223-PIP5K1A
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23756pDONR223-CAMKV
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23757pDONR223-PKM2
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23758pDONR223-RPS6KA5
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23759pDONR223-RIOK1
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23760pDONR223-HIPK4
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23761pDONR223-DYRK1B
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23762pDONR223-ITPKB
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23763pDONR223-AK7
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23764pDONR223-PRKCB2
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23765pDONR223-PRKCH
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23766pDONR223-SRPK2
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23767pDONR223-CKS1B
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23768pDONR223-CALM1
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23769pDONR223-CALM3
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23770pDONR223-STK32A
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23771pDONR223-PMVK
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23772pDONR223-NME5
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23773pDONR223-AK3
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23774pDONR223-TP53RK
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23775pDONR223-TSSK6
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23776pDONR223-CDC2
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23777pDONR223-CDK2
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23778pDONR223-CDK4
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23779pDONR223-CDK5R1
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23780pDONR223-PDXK
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23781pDONR223-NEK6
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23782pDONR223-PBK
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23783pDONR223-MAP2K6
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23784pDONR223-CSNK1A1L
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23785pDONR223-NAGK
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23786pDONR223-CDK7
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23787pDONR223-PRKACB
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23788pDONR223-PRKACG
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23789pDONR223-PRKAR2A
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23790pDONR223-MAPKAPK3
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23791pDONR223-CAMK1D
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23792pDONR223-ETNK2
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23793pDONR223-ADRBK2
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23794pDONR223-BCKDK
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23795pDONR223-STK32B
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23796pDONR223-CSNK1D
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23797pDONR223-CSNK1E
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23798pDONR223-MAP2K7
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23799pDONR223-IHPK2
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23800pDONR223-STK25
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23801pDONR223-PDPK1
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23802pDONR223-STK11
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23803pDONR223-STK40
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23804pDONR223-PDK1
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23805pDONR223-MAP2K5
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23806pDONR223-PIP5K3
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23807pDONR223-ILK
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23808pDONR223-PIK3R3
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23809pDONR223-ADPGK
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23810pDONR223-STK38L
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23811pDONR223-STK38
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23812pDONR223-CAMK4
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23813pDONR223-CAMK1G
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23814pDONR223-CAMK2D
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23816pDONR223-NEK11
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23817pDONR223-CLK1
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23818pDONR223-STK3
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23819pDONR223-PIK3R5
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23820pDONR223-CAMK2B
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23821pDONR223-NEK3
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23822pDONR223-ACVR1
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23823pDONR223-STK33
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23824pDONR223-CAMKK1
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23825pDONR223-DYRK4
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23827pDONR223-GK2
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23828pDONR223-PRKCI
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23829pDONR223-GRK6
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23830pDONR223-TESK1
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23831pDONR223-NUAK2
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23832pDONR223-RAF1
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23833pDONR223-PAK6
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23834pDONR223-LIMK2
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23835pDONR223-ADRBK1
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23836pDONR223-MAPK6
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23837pDONR223-DGKA
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23838pDONR223-SNF1LK
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23839pDONR223-PIK4CB
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23840pDONR223-EIF2AK4
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23841pDONR223-CKS2
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23842pDONR223-RPS6KL1
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23843pDONR223-CHEK2
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23844pDONR223-AAK1
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23845pDONR223-PCTK2
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23846pDONR223-RIPK2
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23847pDONR223-OXSR1
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23848pDONR223-PIP5K1B
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23849pDONR223-ULK4
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23850pDONR223-PAK7
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23851pDONR223-TBK1
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23852pDONR223-HIPK1
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23853pDONR223-MAP3K6
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23854pDONR223-HK2
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23855pDONR223-MAST1
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23856pDONR223-PIK3CG
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23857pDONR223-TTK
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23858pDONR223-BUB1B
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23859pDONR223-PHKB
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23860pDONR223-RPS6KA1
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23861pDONR223-TAOK3
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23862pDONR223-NYD-SP25
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23863pDONR223-UCK2
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23864pDONR223-DGUOK
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23865pDONR223-MAPK14
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23866pDONR223-CKM
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23867pDONR223-PLK1
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23868pDONR223-PAPSS1
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23869pDONR223-PFKP
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23870pDONR223-DAK
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23871pDONR223-PRKAA1
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23872pDONR223-GK
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23873pDONR223-ACVRL1
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23874pDONR223-ERBB3
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23875pDONR223-ERBB4
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23876pDONR223-FES
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23877pDONR223-FGR
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23878pDONR223-FRK
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23879pDONR223-HCK
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23881pDONR223-ITK
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23882pDONR223-MATK
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23883pDONR223-NTRK2
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23884pDONR223-PKMYT1
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23885pDONR223-TEC
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23886pDONR223-TXK
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23887pDONR223-ZAP70
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23888pDONR223-ERBB2
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23889pDONR223-MET
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23890pDONR223-LCK
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23891pDONR223-NTRK1
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23892pDONR223-PDGFRA
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23893pDONR223-PDGFRB
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23894pDONR223-TNK1
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23895pDONR223-FLT3
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23896pDONR223-EPHB4
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23897pDONR223-DDR2
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23898pDONR223-PTK2B
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23899pDONR223-PTK6
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23900pDONR223-MERTK
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23901pDONR223-NTRK3
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23902pDONR223-PTK2
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23903pDONR223-STYK1
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23904pDONR223-FGFR2
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23905pDONR223-LYN
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23906pDONR223-RET
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23907pDONR223-SYK
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23908pDONR223-TYK2
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23909pDONR223-ABL2
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23910pDONR223-DDR1
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23911pDONR223-EPHA3
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23912pDONR223-FLT1
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23914pDONR223-LMTK2
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23915pDONR223-JAK2
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23916pDONR223-TYRO3
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23917pDONR223-ALK
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23918pDONR223-BTK
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23919pDONR223-EPHA4
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23920pDONR223-EPHA6
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23921pDONR223-FER
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23922pDONR223-FGFR1
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23923pDONR223-FLT4
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23924pDONR223-INSRR
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23925pDONR223-KDR
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23926pDONR223-EPHA2
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23927pDONR223-ROR2
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23928pDONR223-CSF1R
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23929pDONR223-EPHA1
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23930pDONR223-EPHB1
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23931pDONR223-EPHB6
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23932pDONR223-JAK1
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23933pDONR223-FGFR3
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23934pDONR223-SRC
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23935pDONR223-EGFR
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23936pDONR223-BMX
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23938pDONR223-YES1
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23939pDONR223-ABL1
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23940pDONR223-BLK
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23941pDONR223-CSK
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23942pDONR223-MST1R
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23943pDONR223-PTK7
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23944pDONR223-JAK3
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23945pDONR223-AXL
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23946pDONR223-TIE1
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