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p5xATF6-GL3 Citations (36)

Originally described in: Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.
Wang Y, Shen J, Arenzana N, Tirasophon W, Kaufman RJ, Prywes R J Biol Chem. 2000 Sep 1. 275(35):27013-20. PubMed Journal

Articles Citing p5xATF6-GL3

Articles
Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress. Takayanagi S, Fukuda R, Takeuchi Y, Tsukada S, Yoshida K. Cell Stress Chaperones. 2013 Jan;18(1):11-23. doi: 10.1007/s12192-012-0351-5. Epub 2012 Jul 18. PubMed
Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines. Pan MY, Shen YC, Lu CH, Yang SY, Ho TF, Peng YT, Chang CC. Toxicol Appl Pharmacol. 2012 Dec 15;265(3):325-34. doi: 10.1016/j.taap.2012.08.034. Epub 2012 Sep 12. PubMed
Subamolide B Isolated from Medicinal Plant Cinnamomum subavenium Induces Cytotoxicity in Human Cutaneous Squamous Cell Carcinoma Cells through Mitochondrial and CHOP-Dependent Cell Death Pathways. Yang SY, Wang HM, Wu TW, Chen YJ, Shieh JJ, Lin JH, Ho TF, Luo RJ, Chen CY, Chang CC. Evid Based Complement Alternat Med. 2013;2013:630415. doi: 10.1155/2013/630415. Epub 2013 Mar 13. PubMed
Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. von Roemeling CA, Marlow LA, Wei JJ, Cooper SJ, Caulfield TR, Wu K, Tan WW, Tun HW, Copland JA. Clin Cancer Res. 2013 May 1;19(9):2368-80. doi: 10.1158/1078-0432.CCR-12-3249. Epub 2013 Apr 30. PubMed
The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Zhang X, Lee SH, Min KW, McEntee MF, Jeong JB, Li Q, Baek SJ. Cancer Prev Res (Phila). 2013 Dec;6(12):1337-47. doi: 10.1158/1940-6207.CAPR-13-0220. Epub 2013 Oct 8. PubMed
Epithelial-to-mesenchymal transition activates PERK-eIF2alpha and sensitizes cells to endoplasmic reticulum stress. Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q, Gupta PB. Cancer Discov. 2014 Jun;4(6):702-15. doi: 10.1158/2159-8290.CD-13-0945. Epub 2014 Apr 4. PubMed
Activation of ER stress by hydrogen peroxide in C2C12 myotubes. Pierre N, Barbe C, Gilson H, Deldicque L, Raymackers JM, Francaux M. Biochem Biophys Res Commun. 2014 Jul 18;450(1):459-63. doi: 10.1016/j.bbrc.2014.05.143. Epub 2014 Jun 8. PubMed
Functional analysis of mutant FAM20C in Raine syndrome with FGF23-related hypophosphatemia. Kinoshita Y, Hori M, Taguchi M, Fukumoto S. Bone. 2014 Oct;67:145-51. doi: 10.1016/j.bone.2014.07.009. Epub 2014 Jul 12. PubMed
Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics. Hussmann M, Janke K, Kranz P, Neumann F, Mersch E, Baumann M, Goepelt K, Brockmeier U, Metzen E. Oncotarget. 2015 Nov 17;6(36):39247-61. doi: 10.18632/oncotarget.5746. PubMed
M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production. Feng J, Gong D, Fu X, Wu TT, Wang J, Chang J, Zhou J, Lu G, Wang Y, Sun R. Sci Rep. 2015 Nov 30;5:17228. doi: 10.1038/srep17228. PubMed
PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response. Gupta A, Hossain MM, Read DE, Hetz C, Samali A, Gupta S. Sci Rep. 2015 Dec 17;5:18304. doi: 10.1038/srep18304. PubMed
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma. Dadey DY, Kapoor V, Khudanyan A, Urano F, Kim AH, Thotala D, Hallahan DE. Oncotarget. 2016 Jan 12;7(2):2080-92. doi: 10.18632/oncotarget.6712. PubMed
VAMP-associated Proteins (VAP) as Receptors That Couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis. Ernst WL, Shome K, Wu CC, Gong X, Frizzell RA, Aridor M. J Biol Chem. 2016 Mar 4;291(10):5206-20. doi: 10.1074/jbc.M115.692749. Epub 2016 Jan 6. PubMed
Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. Peng Y, Kim MJ, Hullinger R, O'Riordan KJ, Burger C, Pehar M, Puglielli L. Brain. 2016 Mar;139(Pt 3):937-52. doi: 10.1093/brain/awv385. Epub 2016 Jan 19. PubMed
Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome. Cagalinec M, Liiv M, Hodurova Z, Hickey MA, Vaarmann A, Mandel M, Zeb A, Choubey V, Kuum M, Safiulina D, Vasar E, Veksler V, Kaasik A. PLoS Biol. 2016 Jul 19;14(7):e1002511. doi: 10.1371/journal.pbio.1002511. eCollection 2016 Jul. PubMed
Longitudinal monitoring of Gaussia and Nano luciferase activities to concurrently assess ER calcium homeostasis and ER stress in vivo. Wires ES, Henderson MJ, Yan X, Back S, Trychta KA, Lutrey MH, Harvey BK. PLoS One. 2017 Apr 12;12(4):e0175481. doi: 10.1371/journal.pone.0175481. eCollection 2017. PubMed

Associated Plasmids
Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells. Ferreira RB, Wang M, Law ME, Davis BJ, Bartley AN, Higgins PJ, Kilberg MS, Santostefano KE, Terada N, Heldermon CD, Castellano RK, Law BK. Oncotarget. 2017 Apr 25;8(17):28971-28989. doi: 10.18632/oncotarget.15952. PubMed
Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response. Schaeffer C, Merella S, Pasqualetto E, Lazarevic D, Rampoldi L. PLoS One. 2017 Apr 24;12(4):e0175970. doi: 10.1371/journal.pone.0175970. eCollection 2017. PubMed
PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR). Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U. Cell Death Dis. 2017 Aug 10;8(8):e2986. doi: 10.1038/cddis.2017.369. PubMed
Aspirin metabolite sodium salicylate selectively inhibits transcriptional activity of ATF6alpha and downstream target genes. Mugge FLB, Silva AM. Sci Rep. 2017 Aug 23;7(1):9190. doi: 10.1038/s41598-017-09500-x. PubMed
TALK-1 channels control beta cell endoplasmic reticulum Ca(2+) homeostasis. Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA. Sci Signal. 2017 Sep 19;10(497). pii: 10/497/eaan2883. doi: 10.1126/scisignal.aan2883. PubMed
Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy. von Roemeling CA, Caulfield TR, Marlow L, Bok I, Wen J, Miller JL, Hughes R, Hazlehurst L, Pinkerton AB, Radisky DC, Tun HW, Kim YSB, Lane AL, Copland JA. Oncotarget. 2017 Oct 6;9(1):3-20. doi: 10.18632/oncotarget.21545. eCollection 2018 Jan 2. PubMed
Hypothermia augments stress response in mammalian cells. Eskla KL, Porosk R, Reimets R, Visnapuu T, Vasar E, Hundahl CA, Luuk H. Free Radic Biol Med. 2018 Jun;121:157-168. doi: 10.1016/j.freeradbiomed.2018.04.571. Epub 2018 Apr 25. PubMed
Diphenyleneiodonium enhances oxidative stress and inhibits Japanese encephalitis virus induced autophagy and ER stress pathways. Sharma M, Sharma KB, Chauhan S, Bhattacharyya S, Vrati S, Kalia M. Biochem Biophys Res Commun. 2018 Jul 12;502(2):232-237. doi: 10.1016/j.bbrc.2018.05.149. Epub 2018 May 24. PubMed
The p38-activated ER stress-ATF6alpha axis mediates cellular senescence. Kim HS, Kim Y, Lim MJ, Park YG, Park SI, Sohn J. FASEB J. 2019 Feb;33(2):2422-2434. doi: 10.1096/fj.201800836R. Epub 2018 Sep 27. PubMed
Activation of the PERK-ATF4 pathway promotes chemo-resistance in colon cancer cells. Shi Z, Yu X, Yuan M, Lv W, Feng T, Bai R, Zhong H. Sci Rep. 2019 Mar 1;9(1):3210. doi: 10.1038/s41598-019-39547-x. PubMed
Autosomal Dominant Tubulointerstitial Kidney Disease with Adult Onset due to a Novel Renin Mutation Mapping in the Mature Protein. Schaeffer C, Izzi C, Vettori A, Pasqualetto E, Cittaro D, Lazarevic D, Caridi G, Gnutti B, Mazza C, Jovine L, Scolari F, Rampoldi L. Sci Rep. 2019 Aug 12;9(1):11601. doi: 10.1038/s41598-019-48014-6. PubMed
Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction. Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB. Cell Metab. 2019 Dec 3;30(6):1141-1151.e5. doi: 10.1016/j.cmet.2019.08.021. Epub 2019 Sep 19. PubMed
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems. Sicari D, Delaunay-Moisan A, Combettes L, Chevet E, Igbaria A. FEBS J. 2020 Jan;287(1):27-42. doi: 10.1111/febs.15107. Epub 2019 Nov 11. PubMed
IRE1beta negatively regulates IRE1alpha signaling in response to endoplasmic reticulum stress. Grey MJ, Cloots E, Simpson MS, LeDuc N, Serebrenik YV, De Luca H, De Sutter D, Luong P, Thiagarajah JR, Paton AW, Paton JC, Seeliger MA, Eyckerman S, Janssens S, Lencer WI. J Cell Biol. 2020 Feb 3;219(2). pii: 133656. doi: 10.1083/jcb.201904048. PubMed
The ATF6-EGF Pathway Mediates the Awakening of Slow-Cycling Chemoresistant Cells and Tumor Recurrence by Stimulating Tumor Angiogenesis. Cho J, Min HY, Pei H, Wei X, Sim JY, Park SH, Hwang SJ, Lee HJ, Hong S, Shin YK, Lee HY. Cancers (Basel). 2020 Jul 2;12(7). pii: cancers12071772. doi: 10.3390/cancers12071772. PubMed
Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress. Kranz P, Sanger C, Wolf A, Baumann J, Metzen E, Baumann M, Gopelt K, Brockmeier U. Sci Rep. 2020 Sep 17;10(1):15299. doi: 10.1038/s41598-020-72259-1. PubMed
The Ca(2+) -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6. Parks SZ, Gao T, Jimenez Awuapura N, Ayathamattam J, Chabosseau PL, Kalvakolanu DV, Valdivia HH, Rutter GA, Leclerc I. FEBS Lett. 2021 Jul;595(13):1782-1796. doi: 10.1002/1873-3468.14101. Epub 2021 May 24. PubMed
Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development. Casellas-Diaz S, Larramona-Arcas R, Rique-Pujol G, Tena-Morraja P, Muller-Sanchez C, Segarra-Mondejar M, Gavalda-Navarro A, Villarroya F, Reina M, Martinez-Estrada OM, Soriano FX. EMBO Rep. 2021 Sep 6;22(9):e51954. doi: 10.15252/embr.202051954. Epub 2021 Jul 23. PubMed
Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit. Hsu HT, Murata A, Dohno C, Nakatani K, Chang K. Nucleic Acids Res. 2022 May 20;50(9):5369-5383. doi: 10.1093/nar/gkac257. PubMed
alpha-Gal A missense variants associated with Fabry disease can lead to ER stress and induction of the unfolded protein response. Consolato F, De Fusco M, Schaeffer C, Pieruzzi F, Scolari F, Gallieni M, Lanzani C, Feriozzi S, Rampoldi L. Mol Genet Metab Rep. 2022 Oct 31;33:100926. doi: 10.1016/j.ymgmr.2022.100926. eCollection 2022 Dec. PubMed

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