pAAV-FLEX-SaCas9-U6-sgRNA Citations (7)

Originally described in: Conditional Single Vector CRISPR/SaCas9 Viruses for Efficient Mutagenesis in the Adult Mouse Nervous System.
Hunker AC, Soden ME, Krayushkina D, Heymann G, Awatramani R, Zweifel LS Cell Rep. 2020 Mar 24;30(12):4303-4316.e6. doi: 10.1016/j.celrep.2020.02.092. PubMed Journal

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Articles Citing pAAV-FLEX-SaCas9-U6-sgRNA

Articles
CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity. Qiu J, Bosch MA, Stincic TL, Hunker AC, Zweifel LS, Ronnekleiv OK, Kelly MJ. Mol Metab. 2022 Dec;66:101645. doi: 10.1016/j.molmet.2022.101645. Epub 2022 Nov 25. PubMed
A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice. Balsevich G, Petrie GN, Heinz DE, Singh A, Aukema RJ, Hunker AC, Vecchiarelli HA, Yau H, Sticht M, Thompson RJ, Lee FS, Zweifel LS, Chelikani PK, Gassen NC, Hill MN. Elife. 2023 Apr 11;12:e81919. doi: 10.7554/eLife.81919. PubMed Associated Plasmids pAAV-CMV-FLEX-SaCas9-U6-sgFAAH
A mesocortical glutamatergic pathway modulates neuropathic pain independent of dopamine co-release. Li M, Yang G. Nat Commun. 2024 Jan 20;15(1):643. doi: 10.1038/s41467-024-45035-2. PubMed
SunTag-PE: a modular prime editing system enables versatile and efficient genome editing. Liu J, Zhang J, Zhao T, Zhao M, Su M, Chen Y, Huang Z, Wang Y, Zhong C, Hu Z, Zhou P, Tian R, He D. Commun Biol. 2025 Mar 18;8(1):452. doi: 10.1038/s42003-025-07893-4. PubMed
Targeted NMDA receptor knockdown in recall-activated neuronal ensembles impairs remote fear extinction. Sung Y, Han DH, Kim J, Park P, Kaang BK. Mol Brain. 2025 Apr 5;18(1):30. doi: 10.1186/s13041-025-01203-z. PubMed
Neuroendocrine circuit for sleep-dependent growth hormone release. Ding X, Hwang FJ, Silverman D, Zhong P, Li B, Ma C, Lu L, Jiang G, Zhang Z, Huang X, Tu X, Tian ZM, Ding J, Dan Y. Cell. 2025 Sep 4;188(18):4968-4979.e12. doi: 10.1016/j.cell.2025.05.039. Epub 2025 Jun 24. PubMed
Chemokine-complement cascade in glial-vascular units protects neurons from non-biogenic nanoparticles. Ogaki A, Kinoshita S, Ikegaya Y, Koyama R. J Neuroinflammation. 2025 Jul 14;22(1):182. doi: 10.1186/s12974-025-03475-7. PubMed

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