pLCKO2::TKOv3 Citations (14)
Originally described in: Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, Kennedy M, Cohen B, Keller G, Moffat J Cell Rep. 2019 Apr 9;27(2):599-615.e12. doi: 10.1016/j.celrep.2019.02.041. PubMed Journal
Articles Citing pLCKO2::TKOv3
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| Pooled CRISPR-Based Genetic Screens in Mammalian Cells. Chan K, Tong AHY, Brown KR, Mero P, Moffat J. J Vis Exp. 2019 Sep 4;(151). doi: 10.3791/59780. PubMed |
| ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation. van der Weegen Y, de Lint K, van den Heuvel D, Nakazawa Y, Mevissen TET, van Schie JJM, San Martin Alonso M, Boer DEC, Gonzalez-Prieto R, Narayanan IV, Klaassen NHM, Wondergem AP, Roohollahi K, Dorsman JC, Hara Y, Vertegaal ACO, de Lange J, Walter JC, Noordermeer SM, Ljungman M, Ogi T, Wolthuis RMF, Luijsterburg MS. Nat Cell Biol. 2021 Jun;23(6):595-607. doi: 10.1038/s41556-021-00688-9. Epub 2021 Jun 9. PubMed |
| CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma. Chen Y, Li L, Lan J, Cui Y, Rao X, Zhao J, Xing T, Ju G, Song G, Lou J, Liang J. Mol Cancer. 2022 Jan 4;21(1):11. doi: 10.1186/s12943-021-01466-9. PubMed |
| P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia. Lin KH, Rutter JC, Xie A, Killarney ST, Vaganay C, Benaksas C, Ling F, Sodaro G, Meslin PA, Bassil CF, Fenouille N, Hoj J, Washart R, Ang HX, Cerda-Smith C, Chaintreuil P, Jacquel A, Auberger P, Forget A, Itzykson R, Lu M, Lin J, Pierobon M, Sheng Z, Li X, Chilkoti A, Owzar K, Rizzieri DA, Pardee TS, Benajiba L, Petricoin E, Puissant A, Wood KC. Nat Cancer. 2022 Jul;3(7):837-851. doi: 10.1038/s43018-022-00394-x. Epub 2022 Jun 6. PubMed |
The SUMO-NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure.
Hertz EPT, Vega IA, Kruse T, Wang Y, Hendriks IA, Bizard AH, Eugui-Anta A, Hay RT, Nielsen ML, Nilsson J, Hickson ID, Mailand N.
Nat Struct Mol Biol. 2023 Jul 20. doi: 10.1038/s41594-023-01045-0.
PubMed
Associated Plasmids |
| A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis. Dickson AS, Pauzaite T, Arnaiz E, Ortmann BM, West JA, Volkmar N, Martinelli AW, Li Z, Wit N, Vitkup D, Kaser A, Lehner PJ, Nathan JA. Nat Commun. 2023 Aug 9;14(1):4816. doi: 10.1038/s41467-023-40541-1. PubMed |
| In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-gamma-induced ferroptosis of hepatocellular carcinoma. Li L, Xing T, Chen Y, Xu W, Fan B, Ju G, Zhao J, Lin L, Yan C, Liang J, Ren X. Cell Death Discov. 2023 Sep 4;9(1):331. doi: 10.1038/s41420-023-01630-8. PubMed |
| LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase. Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. bioRxiv [Preprint]. 2023 Oct 20:2023.10.19.563158. doi: 10.1101/2023.10.19.563158. PubMed |
| Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma. Xing T, Li L, Chen Y, Ju G, Li G, Zhu X, Ren Y, Zhao J, Cheng Z, Li Y, Xu D, Liang J. Cell Rep Med. 2023 Nov 21;4(11):101264. doi: 10.1016/j.xcrm.2023.101264. Epub 2023 Nov 7. PubMed |
| Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting. Labib M, Wang Z, Kim Y, Lin S, Abdrabou A, Yousefi H, Lo PY, Angers S, Sargent EH, Kelley SO. Nat Biomed Eng. 2023 Nov 27. doi: 10.1038/s41551-023-01135-w. PubMed |
| Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2403685121. doi: 10.1073/pnas.2403685121. Epub 2024 May 14. PubMed |
| A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions. Meeusen B, Ambjorn SM, Veis J, Riley RC, Vit G, Brauer BL, Moller MH, Greiner EC, Chan CB, Weisser MB, Garvanska DH, Zhu H, Davey NE, Kettenbach AN, Ogris E, Nilsson J. bioRxiv [Preprint]. 2025 Feb 16:2025.02.12.637884. doi: 10.1101/2025.02.12.637884. PubMed |
| RNA Pol II inhibition activates cell death independently from the loss of transcription. Harper NW, Birdsall GA, Honeywell ME, Ward KM, Pai AA, Lee MJ. Cell. 2025 Oct 30;188(22):6301-6316.e29. doi: 10.1016/j.cell.2025.07.034. Epub 2025 Aug 15. PubMed |
| Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux. Martinelli AW, Wu CP, Vornbaumen T, Coates HW, Jordon LH, Wit N, Sia JJ, Speak AO, Nathan JA. Sci Adv. 2025 Sep 19;11(38):eadw9095. doi: 10.1126/sciadv.adw9095. Epub 2025 Sep 17. PubMed |
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