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pcDNA3-EGFP-RhoA-wt Citations (25)

Originally described in: Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas.
Subauste MC, Von Herrath M, Benard V, Chamberlain CE, Chuang TH, Chu K, Bokoch GM, Hahn KM J Biol Chem. 2000 Mar 31. 275(13):9725-33.
PubMed Journal

Articles Citing pcDNA3-EGFP-RhoA-wt

Elevated cholesterol levels in the plasma membranes of macrophages inhibit migration by disrupting RhoA regulation. Nagao T, Qin C, Grosheva I, Maxfield FR, Pierini LM. Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1596-602. Epub 2007 May 10. PubMed
Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes. Kerr BA, Otani T, Koyama E, Freeman TA, Enomoto-Iwamoto M. Exp Cell Res. 2008 Apr 1;314(6):1301-12. doi: 10.1016/j.yexcr.2007.12.029. Epub 2008 Jan 18. PubMed
Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. Ivanov SS, Charron G, Hang HC, Roy CR. J Biol Chem. 2010 Nov 5;285(45):34686-98. doi: 10.1074/jbc.M110.170746. Epub 2010 Sep 2. PubMed
Structure based design of a Ca2+-sensitive RhoA protein that controls cell morphology. Mills E, Pham E, Truong K. Cell Calcium. 2010 Oct;48(4):195-201. PubMed

Associated Plasmids

Role of Rac1 in regulation of NOX5-S function in Barrett's esophageal adenocarcinoma cells. Hong J, Resnick M, Behar J, Wands J, DeLellis RA, Cao W. Am J Physiol Cell Physiol. 2011 Aug;301(2):C413-20. doi: 10.1152/ajpcell.00027.2011. Epub 2011 Apr 27. PubMed
Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis. Xing L, Yao X, Williams KR, Bassell GJ. Mol Biol Cell. 2012 Apr;23(8):1500-9. doi: 10.1091/mbc.E11-10-0867. Epub 2012 Feb 22. PubMed
A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation. Hornburger MC, Mayer BA, Leonhardt S, Willer EA, Zahler S, Beyerle A, Rajalingam K, Vollmar AM, Furst R. FASEB J. 2014 Apr;28(4):1938-46. doi: 10.1096/fj.13-235754. Epub 2013 Dec 26. PubMed
Intramolecular interactions between the Dbl homology (DH) domain and the carboxyl-terminal region of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) act as an autoinhibitory mechanism for the regulation of MyoGEF functions. Wu D, Jiao M, Zu S, Sollecito CC, Jimenez-Cowell K, Mold AJ, Kennedy RM, Wei Q. J Biol Chem. 2014 Dec 5;289(49):34033-48. doi: 10.1074/jbc.M114.607267. Epub 2014 Oct 21. PubMed
Hypertension Causing Mutations in Cullin3 Impair RhoA Ubiquitination and Augment Association with Substrate Adaptors. Ibeawuchi SC, Agbor LN, Quelle FW, Sigmund CD. J Biol Chem. 2015 Jun 22. pii: jbc.M115.645358. PubMed
Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Lomakin AJ, Lee KC, Han SJ, Bui DA, Davidson M, Mogilner A, Danuser G. Nat Cell Biol. 2015 Nov;17(11):1435-45. doi: 10.1038/ncb3246. Epub 2015 Sep 28. PubMed
Caveolin-1-mediated Japanese encephalitis virus entry requires a two-step regulation of actin reorganization. Xu Q, Cao M, Song H, Chen S, Qian X, Zhao P, Ren H, Tang H, Wang Y, Wei Y, Zhu Y, Qi Z. Future Microbiol. 2016 Mar 17. PubMed
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Yuan X, Cao J, He X, Serra R, Qu J, Cao X, Yang S. Nat Commun. 2016 Mar 21;7:11024. doi: 10.1038/ncomms11024. PubMed
ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens. Priya R, Liang X, Teo JL, Duszyc K, Yap AS, Gomez GA. Mol Biol Cell. 2017 Jan 1;28(1):12-20. doi: 10.1091/mbc.E16-04-0262. Epub 2016 Nov 9. PubMed
Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells. Feng J, Yang H, Zhang Y, Wei H, Zhu Z, Zhu B, Yang M, Cao W, Wang L, Wu Z. Oncogene. 2017 Oct 19;36(42):5829-5839. doi: 10.1038/onc.2017.188. Epub 2017 Jun 12. PubMed
Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism. Singh RK, Haka AS, Brumfield A, Grosheva I, Bhardwaj P, Chin HF, Xiong Y, Hla T, Maxfield FR. J Lipid Res. 2017 Oct;58(10):1977-1987. doi: 10.1194/jlr.M076398. Epub 2017 Aug 16. PubMed
RhoC regulates the actin remodeling required for phagosome formation during FcgammaR-mediated phagocytosis. Egami Y, Kawai K, Araki N. J Cell Sci. 2017 Dec 15;130(24):4168-4179. doi: 10.1242/jcs.202739. Epub 2017 Nov 7. PubMed
RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis. Cortes JR, Ambesi-Impiombato A, Couronne L, Quinn SA, Kim CS, da Silva Almeida AC, West Z, Belver L, Martin MS, Scourzic L, Bhagat G, Bernard OA, Ferrando AA, Palomero T. Cancer Cell. 2018 Feb 12;33(2):259-273.e7. doi: 10.1016/j.ccell.2018.01.001. Epub 2018 Feb 2. PubMed
Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior. Fox ME, Chandra R, Menken MS, Larkin EJ, Nam H, Engeln M, Francis TC, Lobo MK. Mol Psychiatry. 2018 Aug 17. pii: 10.1038/s41380-018-0211-5. doi: 10.1038/s41380-018-0211-5. PubMed
PKCepsilon Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Schaffer TB, Smith JE, Cook EK, Phan T, Margolis SS. Cell Rep. 2018 Nov 27;25(9):2470-2483.e8. doi: 10.1016/j.celrep.2018.11.005. PubMed
Anillin Promotes Cell Contractility by Cyclic Resetting of RhoA Residence Kinetics Budnar S, Husain KB, Gomez GA, Naghibosadat M, Varma A, Verma S, Hamilton NA, Morris RG, Yap AS. Dev Cell. 2019 Jun 17;49(6):894-906.e12. doi: 10.1016/j.devcel.2019.04.031. Epub 2019 May 16. PubMed

Associated Plasmids

Tomosyn regulates the small RhoA GTPase to control the dendritic stability of neurons and the surface expression of AMPA receptors. Shen W, Kilander MBC, Bridi MS, Frei JA, Niescier RF, Huang S, Lin YC. J Neurosci Res. 2020 Jun;98(6):1213-1231. doi: 10.1002/jnr.24608. Epub 2020 Mar 4. PubMed
Effect of Cell Spreading on Rosette Formation by Human Pluripotent Stem Cell-Derived Neural Progenitor Cells. Townshend RF, Shao Y, Wang S, Cortez CL, Esfahani SN, Spence JR, O'Shea KS, Fu J, Gumucio DL, Taniguchi K. Front Cell Dev Biol. 2020 Oct 15;8:588941. doi: 10.3389/fcell.2020.588941. eCollection 2020. PubMed
Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension. McCray BA, Diehl E, Sullivan JM, Aisenberg WH, Zaccor NW, Lau AR, Rich DJ, Goretzki B, Hellmich UA, Lloyd TE, Sumner CJ. Nat Commun. 2021 Mar 4;12(1):1444. doi: 10.1038/s41467-021-21699-y. PubMed
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells. Wu D, Harrison DL, Szasz T, Yeh CF, Shentu TP, Meliton A, Huang RT, Zhou Z, Mutlu GM, Huang J, Fang Y. Nat Metab. 2021 May;3(5):714-727. doi: 10.1038/s42255-021-00390-y. Epub 2021 May 24. PubMed
EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin deposition. Finney AC, Scott ML, Reeves KA, Wang D, Alfaidi M, Schwartz JC, Chitmon CM, Acosta CH, Murphy JM, Alexander JS, Pattillo CB, Lim ST, Orr AW. Matrix Biol. 2021 Sep;103-104:1-21. doi: 10.1016/j.matbio.2021.09.001. Epub 2021 Sep 17. PubMed

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