pLS-SceI Citations (15)
Originally described in: lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements.Gordon MG, Inoue F, Martin B, Schubach M, Agarwal V, Whalen S, Feng S, Zhao J, Ashuach T, Ziffra R, Kreimer A, Georgakopoulous-Soares I, Yosef N, Ye CJ, Pollard KS, Shendure J, Kircher M, Ahituv N Nat Protoc. 2020 Aug;15(8):2387-2412. doi: 10.1038/s41596-020-0333-5. Epub 2020 Jul 8. PubMed Journal
Articles Citing pLS-SceI
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lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements.
Gordon MG, Inoue F, Martin B, Schubach M, Agarwal V, Whalen S, Feng S, Zhao J, Ashuach T, Ziffra R, Kreimer A, Georgakopoulous-Soares I, Yosef N, Ye CJ, Pollard KS, Shendure J, Kircher M, Ahituv N.
Nat Protoc. 2020 Aug;15(8):2387-2412. doi: 10.1038/s41596-020-0333-5. Epub 2020 Jul 8.
PubMed
Associated Plasmids |
| The cis-regulatory effects of modern human-specific variants. Weiss CV, Harshman L, Inoue F, Fraser HB, Petrov DA, Ahituv N, Gokhman D. Elife. 2021 Apr 22;10. pii: 63713. doi: 10.7554/eLife.63713. PubMed |
| Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation. Kreimer A, Ashuach T, Inoue F, Khodaverdian A, Deng C, Yosef N, Ahituv N. Nat Commun. 2022 Mar 21;13(1):1504. doi: 10.1038/s41467-022-28659-0. PubMed |
| Characterization of De Novo Promoter Variants in Autism Spectrum Disorder with Massively Parallel Reporter Assays. Koesterich J, An JY, Inoue F, Sohota A, Ahituv N, Sanders SJ, Kreimer A. Int J Mol Sci. 2023 Feb 9;24(4):3509. doi: 10.3390/ijms24043509. PubMed |
| Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types. Agarwal V, Inoue F, Schubach M, Martin BK, Dash PM, Zhang Z, Sohota A, Noble WS, Yardimci GG, Kircher M, Shendure J, Ahituv N. bioRxiv. 2023 Mar 6:2023.03.05.531189. doi: 10.1101/2023.03.05.531189. Preprint. PubMed |
| Transcription factor binding site orientation and order are major drivers of gene regulatory activity. Georgakopoulos-Soares I, Deng C, Agarwal V, Chan CSY, Zhao J, Inoue F, Ahituv N. Nat Commun. 2023 Apr 22;14(1):2333. doi: 10.1038/s41467-023-37960-5. PubMed |
| Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids. Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, Crawford GE, Ahituv N, Abyzov A, Vaccarino FM. bioRxiv [Preprint]. 2023 Aug 14:2023.08.14.553170. doi: 10.1101/2023.08.14.553170. PubMed |
| Characterization of enhancer activity in early human neurodevelopment using Massively Parallel Reporter Assay (MPRA) and forebrain organoids. Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, Crawford GE, Ahituv N, Abyzov A, Vaccarino FM. Sci Rep. 2024 Feb 16;14(1):3936. doi: 10.1038/s41598-024-54302-7. PubMed |
| Massively parallel reporter assays and mouse transgenic assays provide complementary information about neuronal enhancer activity. Kosicki M, Cintron DL, Page NF, Georgakopoulos-Soares I, Akiyama JA, Plajzer-Frick I, Novak CS, Kato M, Hunter RD, von Maydell K, Barton S, Godfrey P, Beckman E, Sanders SJ, Pennacchio LA, Ahituv N. bioRxiv [Preprint]. 2024 Apr 23:2024.04.22.590634. doi: 10.1101/2024.04.22.590634. PubMed |
| Emergence of activation or repression in transcriptional control under a fixed molecular context. Martinez-Corral R, Friedrich D, Fromel R, Velten L, Gunawardena J, DePace AH. bioRxiv [Preprint]. 2024 Jun 2:2024.05.29.596388. doi: 10.1101/2024.05.29.596388. PubMed |
| Dynamic stress- and inflammatory-based regulation of psychiatric risk loci in human neurons. Retallick-Townsley KG, Lee S, Cartwright S, Cohen S, Sen A, Jia M, Young H, Dobbyn L, Deans M, Fernandez-Garcia M, Huckins LM, Brennand KJ. bioRxiv [Preprint]. 2024 Jul 9:2024.07.09.602755. doi: 10.1101/2024.07.09.602755. PubMed |
| Deciphering the genetics and mechanisms of predisposition to multiple myeloma. Went M, Duran-Lozano L, Halldorsson GH, Gunnell A, Ugidos-Damboriena N, Law P, Ekdahl L, Sud A, Thorleifsson G, Thodberg M, Olafsdottir T, Lamarca-Arrizabalaga A, Cafaro C, Niroula A, Ajore R, Lopez de Lapuente Portilla A, Ali Z, Pertesi M, Goldschmidt H, Stefansdottir L, Kristinsson SY, Stacey SN, Love TJ, Rognvaldsson S, Hajek R, Vodicka P, Pettersson-Kymmer U, Spath F, Schinke C, Van Rhee F, Sulem P, Ferkingstad E, Hjorleifsson Eldjarn G, Mellqvist UH, Jonsdottir I, Morgan G, Sonneveld P, Waage A, Weinhold N, Thomsen H, Forsti A, Hansson M, Juul-Vangsted A, Thorsteinsdottir U, Hemminki K, Kaiser M, Rafnar T, Stefansson K, Houlston R, Nilsson B. Nat Commun. 2024 Aug 5;15(1):6644. doi: 10.1038/s41467-024-50932-7. PubMed |
| Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk. Law PJ, Studd J, Smith J, Vijayakrishnan J, Harris BT, Mandelia M, Mills C, Dunlop MG, Houlston RS. Nat Genet. 2024 Oct;56(10):2104-2111. doi: 10.1038/s41588-024-01900-w. Epub 2024 Sep 16. PubMed |
| Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance. Wang QS, Hasegawa T, Namkoong H, Saiki R, Edahiro R, Sonehara K, Tanaka H, Azekawa S, Chubachi S, Takahashi Y, Sakaue S, Namba S, Yamamoto K, Shiraishi Y, Chiba K, Tanaka H, Makishima H, Nannya Y, Zhang Z, Tsujikawa R, Koike R, Takano T, Ishii M, Kimura A, Inoue F, Kanai T, Fukunaga K, Ogawa S, Imoto S, Miyano S, Okada Y. Nat Genet. 2024 Oct;56(10):2054-2067. doi: 10.1038/s41588-024-01896-3. Epub 2024 Sep 24. PubMed |
| Massively parallel characterization of transcriptional regulatory elements. Agarwal V, Inoue F, Schubach M, Penzar D, Martin BK, Dash PM, Keukeleire P, Zhang Z, Sohota A, Zhao J, Georgakopoulos-Soares I, Noble WS, Yardimci GG, Kulakovskiy IV, Kircher M, Shendure J, Ahituv N. Nature. 2025 Mar;639(8054):411-420. doi: 10.1038/s41586-024-08430-9. Epub 2025 Jan 15. PubMed |
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