HDAC6 Flag Citations (34)
Originally described in: A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p.Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E J Biol Chem. 1999 Apr 23. 274(17):11713-20. PubMed Journal
Articles Citing HDAC6 Flag
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| Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts. Sudo H, Baas PW. J Neurosci. 2010 May 26;30(21):7215-26. doi: 10.1523/JNEUROSCI.0048-10.2010. PubMed |
| Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases. Sudo H, Baas PW. Hum Mol Genet. 2011 Feb 15;20(4):763-78. doi: 10.1093/hmg/ddq521. Epub 2010 Nov 30. PubMed |
| Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation. Di Fulvio S, Azakir BA, Therrien C, Sinnreich M. PLoS One. 2011;6(12):e28563. doi: 10.1371/journal.pone.0028563. Epub 2011 Dec 8. PubMed |
| Deacetylated alphabeta-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading. Lee MN, Koh A, Park D, Jang JH, Kwak D, Jeon H, Kim J, Choi EJ, Jeong H, Suh PG, Ryu SH. Cell Signal. 2013 Feb;25(2):539-51. doi: 10.1016/j.cellsig.2012.11.006. Epub 2012 Nov 20. PubMed |
| HDAC6 inhibition restores ciliary expression and decreases tumor growth. Gradilone SA, Radtke BN, Bogert PS, Huang BQ, Gajdos GB, LaRusso NF. Cancer Res. 2013 Apr 1;73(7):2259-70. doi: 10.1158/0008-5472.CAN-12-2938. Epub 2013 Jan 31. PubMed |
| Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1beta signaling in osteoarthritis fibroblast-like synoviocytes. Wang JH, Shih KS, Wu YW, Wang AW, Yang CR. Osteoarthritis Cartilage. 2013 Dec;21(12):1987-96. doi: 10.1016/j.joca.2013.09.008. Epub 2013 Oct 6. PubMed |
| Overexpression of the transcriptional repressor complex BCL-6/BCoR leads to nuclear aggregates distinct from classical aggresomes. Buchberger E, El Harchi M, Payrhuber D, Zommer A, Schauer D, Simonitsch-Klupp I, Bilban M, Brostjan C. PLoS One. 2013 Oct 11;8(10):e76845. doi: 10.1371/journal.pone.0076845. eCollection 2013. PubMed |
| Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivation. Shin HJ, DeCotiis J, Giron M, Palmeri D, Lukac DM. J Virol. 2014 Jan;88(2):1281-92. doi: 10.1128/JVI.02665-13. Epub 2013 Nov 13. PubMed |
MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly.
Joo EE, Yamada KM.
Nat Commun. 2014 Mar 25;5:3510. doi: 10.1038/ncomms4510.
PubMed
Associated Plasmids |
| Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009. Hsieh IN, Liou JP, Lee HY, Lai MJ, Li YH, Yang CR. Cell Death Dis. 2014 Apr 10;5:e1166. doi: 10.1038/cddis.2014.133. PubMed |
| Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. Nakashima H, Nguyen T, Goins WF, Chiocca EA. J Biol Chem. 2015 Jan 16;290(3):1485-95. doi: 10.1074/jbc.M114.593871. Epub 2014 Nov 26. PubMed |
| Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo. Huang HL, Peng CY, Lai MJ, Chen CH, Lee HY, Wang JC, Liou JP, Pan SL, Teng CM. Oncotarget. 2015 Mar 10;6(7):4976-91. PubMed |
| Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. Salian-Mehta S, Xu M, McKinsey TA, Tobet S, Wierman ME. J Biol Chem. 2015 May 29;290(22):14045-56. doi: 10.1074/jbc.M115.640482. Epub 2015 Apr 14. PubMed |
| PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. Meng Z, Jia LF, Gan YH. Oncogene. 2015 Aug 17. doi: 10.1038/onc.2015.293. PubMed |
| The size of the primary cilium and acetylated tubulin are modulated during adipocyte differentiation: Analysis of HDAC6 functions in these processes. Forcioli-Conti N, Esteve D, Bouloumie A, Dani C, Peraldi P. Biochimie. 2015 Sep 10. pii: S0300-9084(15)00286-2. doi: 10.1016/j.biochi.2015.09.011. PubMed |
| Nuclear HDAC6 inhibits invasion by suppressing NF-kappaB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer. Yang CJ, Liu YP, Dai HY, Shiue YL, Tsai CJ, Huang MS, Yeh YT. Oncotarget. 2015 Oct 6;6(30):30263-76. doi: 10.18632/oncotarget.4749. PubMed |
| Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma. Nakashima H, Kaufmann JK, Wang PY, Nguyen T, Speranza MC, Kasai K, Okemoto K, Otsuki A, Nakano I, Fernandez S, Goins WF, Grandi P, Glorioso JC, Lawler S, Cripe TP, Chiocca EA. J Clin Invest. 2015 Nov 2;125(11):4269-80. doi: 10.1172/JCI80713. Epub 2015 Oct 20. PubMed |
| Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma. Chen MC, Huang HH, Lai CY, Lin YJ, Liou JP, Lai MJ, Li YH, Teng CM, Yang CR. Oncotarget. 2016 Jan 5;7(1):402-17. doi: 10.18632/oncotarget.6352. PubMed |
| The Actin-Binding Protein Cofilin and its Interaction with Cortactin Are Required for Podosome Patterning in Osteoclasts and Bone Resorption In Vivo and In Vitro. Zalli D, Neff L, Nagano K, Shin NY, Witke W, Gori F, Baron R. J Bone Miner Res. 2016 Apr 11. doi: 10.1002/jbmr.2851. PubMed |
| Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6. Liu HM, Jiang F, Loo YM, Hsu S, Hsiang TY, Marcotrigiano J, Gale M Jr. EBioMedicine. 2016 Jul;9:195-206. doi: 10.1016/j.ebiom.2016.06.015. Epub 2016 Jun 11. PubMed |
Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Hai Y, Christianson DW.
Nat Chem Biol. 2016 Sep;12(9):741-7. doi: 10.1038/nchembio.2134. Epub 2016 Jul 25.
PubMed
Associated Plasmids |
| WMJ-8-B, a novel hydroxamate derivative, induces MDA-MB-231 breast cancer cell death via SHP-1-STAT3-survivin cascade. Chuang YF, Huang SW, Hsu YF, Yu MC, Ou G, Huang WJ, Hsu MJ. Br J Pharmacol. 2017 Jun 23. doi: 10.1111/bph.13929. PubMed |
| Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates. Toro TB, Bryant JR, Watt TJ. Biochemistry. 2017 Aug 29;56(34):4549-4558. doi: 10.1021/acs.biochem.7b00270. Epub 2017 Aug 16. PubMed |
| G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin. Wang YF, Zhang J, Su Y, Shen YY, Jiang DX, Hou YY, Geng MY, Ding J, Chen Y. Nat Commun. 2017 Aug 17;8(1):274. doi: 10.1038/s41467-017-00350-9. PubMed |
| Purification of metal-dependent lysine deacetylases with consistently high activity. Toro TB, Painter RG, Haynes RA, Glotser EY, Bratton MR, Bryant JR, Nichols KA, Matthew-Onabanjo AN, Matthew AN, Bratcher DR, Perry CD, Watt TJ. Protein Expr Purif. 2018 Jan;141:1-6. doi: 10.1016/j.pep.2017.08.009. Epub 2017 Aug 24. PubMed |
| P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity. Kalogeropulou AF, Zhao J, Bolliger MF, Memou A, Narasimha S, Molitor TP, Wilson WH, Rideout HJ, Nichols RJ. Biochem J. 2018 Apr 9;475(7):1271-1293. doi: 10.1042/BCJ20170699. PubMed |
| p38delta MAPK regulates aggresome biogenesis by phosphorylating SQSTM1 in response to proteasomal stress. Zhang C, Gao J, Li M, Deng Y, Jiang C. J Cell Sci. 2018 Jul 26;131(14). pii: jcs.216671. doi: 10.1242/jcs.216671. PubMed |
| The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells. Tu HJ, Lin YJ, Chao MW, Sung TY, Wu YW, Chen YY, Lin MH, Liou JP, Pan SL, Yang CR. Clin Epigenetics. 2018 Dec 29;10(1):162. doi: 10.1186/s13148-018-0595-8. PubMed |
| HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models. Peixoto E, Jin S, Thelen K, Biswas A, Richard S, Morleo M, Mansini A, Holtorf S, Carbone F, Pastore N, Ballabio A, Franco B, Gradilone SA. Am J Physiol Gastrointest Liver Physiol. 2020 Jun 1;318(6):G1022-G1033. doi: 10.1152/ajpgi.00033.2020. Epub 2020 Apr 27. PubMed |
| Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells. Mundhara N, Majumder A, Panda D. Biochem J. 2021 Jan 15;478(1):179-196. doi: 10.1042/BCJ20200705. PubMed |
| ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses. Bruce JW, Bracken M, Evans E, Sherer N, Ahlquist P. PLoS Pathog. 2021 Feb 26;17(2):e1009364. doi: 10.1371/journal.ppat.1009364. eCollection 2021 Feb. PubMed |
| Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation. Nomura Y, Nakano M, Woo Sung H, Han M, Pandey D. Front Physiol. 2021 Jun 17;12:675724. doi: 10.3389/fphys.2021.675724. eCollection 2021. PubMed |
| Tubulin acetylation promotes penetrative capacity of cells undergoing radial intercalation. Collins C, Kim SK, Ventrella R, Carruzzo HM, Wortman JC, Han H, Suva EE, Mitchell JW, Yu CC, Mitchell BJ. Cell Rep. 2021 Aug 17;36(7):109556. doi: 10.1016/j.celrep.2021.109556. PubMed |
| HDAC6 promotes aggressive development of liver cancer by improving egfr mRNA stability. Dai HY, Chang LS, Yang SF, Wang SN, Su SJ, Yeh YT. Neoplasia. 2023 Jan;35:100845. doi: 10.1016/j.neo.2022.100845. Epub 2022 Nov 2. PubMed |
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