COVID-SARS2 NSP13 Citations (10)

Originally described in: Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.
Newman JA, Douangamath A, Yadzani S, Yosaatmadja Y, Aimon A, Brandao-Neto J, Dunnett L, Gorrie-Stone T, Skyner R, Fearon D, Schapira M, von Delft F, Gileadi O Nat Commun. 2021 Aug 11;12(1):4848. doi: 10.1038/s41467-021-25166-6. PubMed Journal

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Articles Citing COVID-SARS2 NSP13

Articles
NOS-2 participates in the behavioral effects of ethanol withdrawal in zebrafish. da Silva Chaves SN, Dutra Costa BP, Vidal Gomes GC, Lima-Maximino M, Pacheco Rico E, Maximino C. Neurosci Lett. 2020 May 29;728:134952. doi: 10.1016/j.neulet.2020.134952. Epub 2020 Apr 11. PubMed
Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach. Romeo I, Ambrosio FA, Costa G, Corona A, Alkhatib M, Salpini R, Lemme S, Vergni D, Svicher V, Santoro MM, Tramontano E, Ceccherini-Silberstein F, Artese A, Alcaro S. Molecules. 2022 Nov 3;27(21):7522. doi: 10.3390/molecules27217522. PubMed
DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action. Iaconis D, Caccuri F, Manelfi C, Talarico C, Bugatti A, Filippini F, Zani A, Novelli R, Kuzikov M, Ellinger B, Gribbon P, Riecken K, Esposito F, Corona A, Tramontano E, Beccari AR, Caruso A, Allegretti M. Viruses. 2023 May 9;15(5):1128. doi: 10.3390/v15051128. PubMed
Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication. Corona A, Madia VN, De Santis R, Manelfi C, Emmolo R, Ialongo D, Patacchini E, Messore A, Amatore D, Faggioni G, Artico M, Iaconis D, Talarico C, Di Santo R, Lista F, Costi R, Tramontano E. Antiviral Res. 2023 Sep;217:105697. doi: 10.1016/j.antiviral.2023.105697. Epub 2023 Aug 9. PubMed
Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays. Inniss NL, Rzhetskaya M, Ling-Hu T, Lorenzo-Redondo R, Bachta KE, Satchell KJF, Hultquist JF. SLAS Discov. 2024 Apr;29(3):100145. doi: 10.1016/j.slasd.2024.01.006. Epub 2024 Feb 1. PubMed
Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex. Kuzikov M, Reinshagen J, Wycisk K, Corona A, Esposito F, Malune P, Manelfi C, Iaconis D, Beccari A, Tramontano E, Nowotny M, Windshugel B, Gribbon P, Zaliani A. Virus Res. 2024 May;343:199356. doi: 10.1016/j.virusres.2024.199356. Epub 2024 Mar 16. PubMed
A novel ADP-directed chaperone function facilitates the ATP-driven motor activity of SARS-CoV helicase. Yu J, Im H, Cho H, Jeon Y, Lee JB, Lee G. Nucleic Acids Res. 2025 Jan 24;53(3):gkaf034. doi: 10.1093/nar/gkaf034. PubMed
Monitoring SARS-CoV-2 Nsp13 helicase binding activity using expanded genetic code techniques. Lundrigan E, Hum C, Ahmed N, Pezacki JP. RSC Chem Biol. 2025 Apr 21;6(6):860-868. doi: 10.1039/d4cb00230j. eCollection 2025 Jun 4. PubMed
Structure-Activity Relationships of New 1-Aryl-1H-Indole Derivatives as SARS-CoV-2 Nsp13 Inhibitors. Madia VN, Emmolo R, Patacchini E, Amatore D, Maloccu S, Ialongo D, Albano A, Ruggieri G, Cara E, Zarbo L, Messore A, De Santis R, Amoroso A, Lista F, Esposito F, Tramontano E, Corona A, Di Santo R, Costi R. ChemMedChem. 2025 Jul 18;20(14):e202500205. doi: 10.1002/cmdc.202500205. Epub 2025 May 20. PubMed
N-alkyl and N-benzyl indoles are anti-SARS-CoV-2 agents and nsp13 inhibitors. Albano A, Emmolo R, De Santis R, Patacchini E, Madia VN, Maloccu S, Ialongo D, Ruggieri G, Arpacioglu M, Scipione L, Saccoliti F, Amatore D, Grilli G, Lista F, Esposito F, Tramontano E, Corona A, Di Santo R, Costi R. J Enzyme Inhib Med Chem. 2025 Aug 7;40(1):2539445. doi: 10.1080/14756366.2025.2539445. Epub 2025 Aug 12. PubMed

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