pLenti-gRNA-puro Citations (3)
Originally described in: Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9.Sapozhnikov DM, Szyf M Nat Commun. 2021 Sep 29;12(1):5711. doi: 10.1038/s41467-021-25991-9. PubMed Journal
Articles Citing pLenti-gRNA-puro
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| Enzyme-free targeted DNA demethylation using CRISPR-dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression. Sapozhnikov DM, Szyf M. Nat Protoc. 2022 Dec;17(12):2840-2881. doi: 10.1038/s41596-022-00741-3. Epub 2022 Oct 7. PubMed |
The PROTECTOR strategy employs dCas orthologs to sterically shield off-target sites from CRISPR/Cas activity.
Sapozhnikov DM, Szyf M.
Sci Rep. 2023 Feb 9;13(1):2280. doi: 10.1038/s41598-023-29332-2.
PubMed
Associated Plasmids |
| Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition. Mahmood N, Arakelian A, Szyf M, Rabbani SA. Exp Mol Med. 2024 Apr;56(4):959-974. doi: 10.1038/s12276-024-01205-2. Epub 2024 Apr 1. PubMed |
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