pET 15b+His SUMO Rab12 (Q101L) Citations (4)
Originally described in: Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.Dhekne HS, Tonelli F, Yeshaw WM, Chiang CY, Limouse C, Jaimon E, Purlyte E, Alessi DR, Pfeffer SR Elife. 2023 Oct 24;12:e87098. doi: 10.7554/eLife.87098. PubMed Journal
Articles Citing pET 15b+His SUMO Rab12 (Q101L)
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| PPM1M, a LRRK2-counteracting, phosphoRab12-preferring phosphatase with potential link to Parkinson's disease. Chiang CY, Pratuseviciute N, Lin YE, Adhikari A, Yeshaw WM, Flitton C, Sherpa PL, Tonelli F, Rektorova I, Lynch T, Siuda J, Rudzinska-Bar M, Pulyk O, Bauer P, Beetz C, Dickson DW, Ross OA, Wszolek ZK, Klein C, Zimprich A, Alessi DR, Sammler EM, Pfeffer SR. bioRxiv [Preprint]. 2025 Mar 19:2025.03.19.644182. doi: 10.1101/2025.03.19.644182. PubMed |
| End-product inhibition of the LRRK2-counteracting PPM1H phosphatase. Adhikari A, Tripathi A, Chiang CY, Sherpa P, Pfeffer SR. bioRxiv [Preprint]. 2025 May 17:2025.05.16.654599. doi: 10.1101/2025.05.16.654599. PubMed |
| PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson's disease. Chiang CY, Pratuseviciute N, Lin YE, Adhikari A, Yeshaw WM, Flitton C, Sherpa PL, Tonelli F, Rektorova I, Lynch T, Siuda J, Rudzinska-Bar M, Pulyk O, Bauer P, Beetz C, Dickson DW, Ross OA, Wszolek ZK, Fang ZH, Klein C, Zimprich A, Alessi DR, Sammler EM, Pfeffer SR. Cell Rep. 2025 Aug 26;44(8):116031. doi: 10.1016/j.celrep.2025.116031. Epub 2025 Jul 20. PubMed |
Allosteric regulation of the Golgi-localized PPM1H phosphatase by Rab GTPases modulates LRRK2 substrate dephosphorylation in Parkinson's disease.
Adhikari A, Tripathi A, Chiang CY, Sherpa P, Pfeffer SR.
J Biol Chem. 2025 Sep 3:110679. doi: 10.1016/j.jbc.2025.110679.
PubMed
Associated Plasmids |
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