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pLV[Exp]-Bsd-CMV>hCDK11B D562A, G579S
(Plasmid #239218)

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This material is available to academics and nonprofits only.
Item Catalog # Description Quantity Price (USD)
Plasmid 239218 Standard format: Plasmid sent in bacteria as agar stab 1 $89
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Backbone

  • Vector backbone
    pLV[Exp]-Bsd-CMV
  • Vector type
    Mammalian Expression, Lentiviral
  • Selectable markers
    Blasticidin

Growth in Bacteria

  • Bacterial Resistance(s)
    Ampicillin, 100 μg/mL
  • Growth Temperature
    37°C
  • Growth Strain(s)
    NEB Stable
  • Copy number
    Unknown

Gene/Insert

  • Gene/Insert name
    cyclin dependent kinase 11B with D562A kinase inactivating mutation and G579S resistance mutation
  • Alt name
    CDK11B-D562A+G579S
  • Species
    H. sapiens (human)
  • Mutation
    changed Aspartic acid 562 to Alanine and changed Glycine 579 to Serine
  • Entrez Gene
    CDK11B (a.k.a. CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1)

Resource Information

Terms and Licenses

  • Academic/Nonprofit Terms
  • Industry Terms
    • Not Available to Industry
Trademarks:
  • Zeocin® is an InvivoGen trademark.

Depositor Comments

Please visit https://doi.org/10.1101/2025.08.03.668359 for bioRxiv preprint.

How to cite this plasmid ( Back to top)

These plasmids were created by your colleagues. Please acknowledge the Principal Investigator, cite the article in which the plasmids were described, and include Addgene in the Materials and Methods of your future publications.

  • For your Materials & Methods section:

    pLV[Exp]-Bsd-CMV>hCDK11B D562A, G579S was a gift from Jason Sheltzer (Addgene plasmid # 239218 ; http://n2t.net/addgene:239218 ; RRID:Addgene_239218)

  • For your References section:

    On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions. Julian LA, Crozier L, Lukow D, Mishra S, Swamy A, Hagenson RA, Sennhenn P, Sausville EL, Mendelson B, Chuaqui C, Qiao L, Vasudevan A, Lin K-T, Bhatia S, Bertomeu T, Chatr-aryamontri A, Zhang L, Rees MG, Ronan MM, Roth JA, Nottoli T, Bai S, Lakshmipathi J, Muthusamy V, Van Vranken JG, Gygi SP, Thompson SL, Smith JC, Anderson K, Shah S, Bindra RS, Akerman M, Spector DL, Krainer AR, Sheltzer JM. bioRxiv 2025.08.03.668359; doi: https://doi.org/10.1101/2025.08.03.668359 10.1101/2025.08.03.668359
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