pDEST53-LRRK2-WT Citations (15)

Originally described in: Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, Harvey RJ, Harvey K, Cookson MR Neurobiol Dis. 2006 Aug . 23(2):329-41. PubMed Journal

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Articles Citing pDEST53-LRRK2-WT

Articles
Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. Su YC, Guo X, Qi X. Biochim Biophys Acta. 2015 Jan;1852(1):12-21. doi: 10.1016/j.bbadis.2014.11.009. Epub 2014 Nov 15. PubMed
Wild-type and mutant (G2019S) leucine-rich repeat kinase 2 (LRRK2) associate with subunits of the translocase of outer mitochondrial membrane (TOM) complex. Neethling A, Engelbrecht L, Loos B, Kinnear C, Theart R, Abrahams S, Niesler T, Mellick GD, Williams M, Bardien S. Exp Cell Res. 2019 Feb 15;375(2):72-79. doi: 10.1016/j.yexcr.2018.12.022. Epub 2018 Dec 28. PubMed
Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or alpha-synuclein, is localized to the mitochondrial matrix. Osuagwu N, Dolle C, Tzoulis C. PLoS One. 2019 Jul 19;14(7):e0219909. doi: 10.1371/journal.pone.0219909. eCollection 2019. PubMed
Structural analysis of the full-length human LRRK2. Myasnikov A, Zhu H, Hixson P, Xie B, Yu K, Pitre A, Peng J, Sun J. Cell. 2021 Jun 24;184(13):3519-3527.e10. doi: 10.1016/j.cell.2021.05.004. Epub 2021 Jun 8. PubMed
miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson's Disease. Oliveira SR, Dionisio PA, Gaspar MM, Correia Guedes L, Coelho M, Rosa MM, Ferreira JJ, Amaral JD, Rodrigues CMP. Front Cell Dev Biol. 2021 Jun 15;9:661461. doi: 10.3389/fcell.2021.661461. eCollection 2021. PubMed
Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease. Lin YE, Lin CH, Ho EP, Ke YC, Petridi S, Elliott CJ, Sheen LY, Chien CT. Elife. 2021 Nov 15;10. pii: 73753. doi: 10.7554/eLife.73753. PubMed
Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement. Fdez E, Madero-Perez J, Lara Ordonez AJ, Naaldijk Y, Fasiczka R, Aiastui A, Ruiz-Martinez J, Lopez de Munain A, Cowley SA, Wade-Martins R, Hilfiker S. iScience. 2022 May 30;25(6):104476. doi: 10.1016/j.isci.2022.104476. eCollection 2022 Jun 17. PubMed
Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules. Snead DM, Matyszewski M, Dickey AM, Lin YX, Leschziner AE, Reck-Peterson SL. Nat Struct Mol Biol. 2022 Dec;29(12):1196-1207. doi: 10.1038/s41594-022-00863-y. Epub 2022 Dec 12. PubMed
Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs. Filippini F, Nola S, Zahraoui A, Roger K, Esmaili M, Sun J, Wojnacki J, Vlieghe A, Bun P, Blanchon S, Rain JC, Taymans JM, Chartier-Harlin MC, Guerrera C, Galli T. Cell Rep. 2023 Mar 28;42(3):112221. doi: 10.1016/j.celrep.2023.112221. Epub 2023 Mar 10. PubMed
Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM. Zhu H, Hixson P, Ma W, Sun J. Cell Discov. 2024 Jan 23;10(1):10. doi: 10.1038/s41421-023-00639-8. PubMed
Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells. Zhu H, Sydor AM, Yan BR, Li R, Boniecki MT, Lyons C, Cygler M, Muise AM, Maxson ME, Grinstein S, Raught B, Brumell JH. Nat Commun. 2025 Mar 8;16(1):2329. doi: 10.1038/s41467-025-57453-x. PubMed
The Leucine-Rich Repeat Kinase 2 Variant LRRK2(G2019S) Up-Regulates L-Type (CaV1.3) Calcium Channel via the Ca(V)beta(3) Subunit: Possible Role in the Pathogenesis of Parkinson's Disease. Sandoval A, Corzo-Lopez A, Duran P, Tovar-Soto D, Vargas-Caballero B, Galicia-Saldana V, Gonzalez-Ramirez R, Felix R. Int J Mol Sci. 2025 Mar 31;26(7):3229. doi: 10.3390/ijms26073229. PubMed
LRRK2 interactions with microtubules are independent of LRRK2-mediated Rab phosphorylation. Malankhanova T, Liu Z, Xu E, Bryant N, Sung KW, Li H, Strader S, West AB. EMBO Rep. 2025 Jul;26(13):3445-3466. doi: 10.1038/s44319-025-00486-6. Epub 2025 May 27. PubMed
A new LRRK2 variant in a family with Parkinson's disease affects binding to RAB8A. Vela-Desojo L, Pascual A, Montal V, Guerrero C, Osuna-Lopez M, Guallar V, Palau F, Hoenicka J. NPJ Parkinsons Dis. 2025 Jun 7;11(1):154. doi: 10.1038/s41531-025-00989-y. PubMed
Selectivity profiles and substrate recognition of Rab-phosphorylating kinases. Chatterjee D, Dederer V, Nguyen LV, Wendel M, Abdul Azeez KR, Mahesula S, Stengel F, Reck-Peterson S, Mathea S. Biochem J. 2025 Sep 4;482(17):1307-19. doi: 10.1042/BCJ20253212. PubMed

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