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8xGTIIC-luciferase Citations (137)

Plasmid Article: Role of YAP/TAZ in mechanotransduction.
Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, Elvassore N, Piccolo S Nature. 2011 Jun 8;474(7350):179-83. doi: 10.1038/nature10137.
PubMed Journal

Articles Citing 8xGTIIC-luciferase

Articles
A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N, Dupont S, Piccolo S. Cell. 2013 Aug 29;154(5):1047-59. doi: 10.1016/j.cell.2013.07.042. Epub 2013 Aug 15. PubMed
Angiomotins link F-actin architecture to Hippo pathway signaling. Mana-Capelli S, Paramasivam M, Dutta S, McCollum D. Mol Biol Cell. 2014 May;25(10):1676-85. doi: 10.1091/mbc.E13-11-0701. Epub 2014 Mar 19. PubMed
Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstadt H, Duning K, Kremerskothen J. Mol Biol Evol. 2014 Jul;31(7):1710-23. doi: 10.1093/molbev/msu115. Epub 2014 Mar 27. PubMed
Alpha-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Aguilar A, Becker L, Tedeschi T, Heller S, Iomini C, Nachury MV. Mol Biol Cell. 2014 Jun 15;25(12):1854-66. doi: 10.1091/mbc.E13-10-0609. Epub 2014 Apr 17. PubMed
Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest. Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA. Cell Rep. 2014 Dec 11;9(5):1885-95. doi: 10.1016/j.celrep.2014.10.061. Epub 2014 Nov 26. PubMed
Aerobic glycolysis tunes YAP/TAZ transcriptional activity. Enzo E, Santinon G, Pocaterra A, Aragona M, Bresolin S, Forcato M, Grifoni D, Pession A, Zanconato F, Guzzo G, Bicciato S, Dupont S. EMBO J. 2015 May 12;34(10):1349-70. doi: 10.15252/embj.201490379. Epub 2015 Mar 21. PubMed
Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking. Kim J, Jo H, Hong H, Kim MH, Kim JM, Lee JK, Heo WD, Kim J. Nat Commun. 2015 Apr 7;6:6781. doi: 10.1038/ncomms7781. PubMed
NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling. Clattenburg L, Wigerius M, Qi J, Rainey JK, Rourke JL, Muruganandan S, Sinal CJ, Fawcett JP. Mol Cell Biol. 2015 Jul 1;35(13):2265-77. doi: 10.1128/MCB.00062-15. Epub 2015 Apr 27. PubMed
Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. Choi HJ, Zhang H, Park H, Choi KS, Lee HW, Agrawal V, Kim YM, Kwon YG. Nat Commun. 2015 May 12;6:6943. doi: 10.1038/ncomms7943. PubMed
beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Cai J, Maitra A, Anders RA, Taketo MM, Pan D. Genes Dev. 2015 Jul 15;29(14):1493-506. doi: 10.1101/gad.264515.115. Epub 2015 Jul 20. PubMed
Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers. Oku Y, Nishiya N, Shito T, Yamamoto R, Yamamoto Y, Oyama C, Uehara Y. FEBS Open Bio. 2015 Jun 22;5:542-9. doi: 10.1016/j.fob.2015.06.007. eCollection 2015. PubMed
CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity. Zhang L, Chen X, Stauffer S, Yang S, Chen Y, Dong J. Oncotarget. 2015 Oct 13;6(31):31399-412. doi: 10.18632/oncotarget.5189. PubMed
Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3. Yang S, Zhang L, Purohit V, Shukla SK, Chen X, Yu F, Fu K, Chen Y, Solheim J, Singh PK, Song W, Dong J. Oncotarget. 2015 Nov 3;6(34):36019-31. doi: 10.18632/oncotarget.5935. PubMed
Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells. Ukita M, Yamaguchi T, Ohata N, Tamura M. J Cell Biochem. 2015 Nov 10. doi: 10.1002/jcb.25432. PubMed
The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. Kimura TE, Duggirala A, Smith MC, White S, Sala-Newby GB, Newby AC, Bond M. J Mol Cell Cardiol. 2016 Jan;90:1-10. doi: 10.1016/j.yjmcc.2015.11.024. Epub 2015 Nov 25. PubMed
Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation. Kim MH, Kim J, Hong H, Lee SH, Lee JK, Jung E, Kim J. EMBO J. 2016 Mar 1;35(5):462-78. doi: 10.15252/embj.201592081. Epub 2015 Dec 14. PubMed
Human pluripotent stem cell culture density modulates YAP signaling. Hsiao C, Lampe M, Nillasithanukroh S, Han W, Lian X, Palecek SP. Biotechnol J. 2016 Jan 14. doi: 10.1002/biot.201500374. PubMed
The characterisation of LATS2 kinase regulation in Hippo-YAP signalling. Hoa L, Kulaberoglu Y, Gundogdu R, Cook D, Mavis M, Gomez M, Gomez V, Hergovich A. Cell Signal. 2016 May;28(5):488-97. doi: 10.1016/j.cellsig.2016.02.012. Epub 2016 Feb 18. PubMed
RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3. Jang JW, Kim MK, Lee YS, Lee JW, Kim DM, Song SH, Lee JY, Choi BY, Min B, Chi XZ, Bae SC. Oncogene. 2016 Jul 18. doi: 10.1038/onc.2016.266. PubMed
IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity. Sayedyahossein S, Li Z, Hedman AC, Morgan CJ, Sacks DB. J Biol Chem. 2016 Sep 9;291(37):19261-73. doi: 10.1074/jbc.M116.732529. Epub 2016 Jul 20. PubMed
Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse. Corvaisier M, Bauzone M, Corfiotti F, Renaud F, El Amrani M, Monte D, Truant S, Leteurtre E, Formstecher P, Van Seuningen I, Gespach C, Huet G. Oncotarget. 2016 Aug 30;7(35):56699-56712. doi: 10.18632/oncotarget.11057. PubMed
p66Shc couples mechanical signals to RhoA through FAK-dependent recruitment of p115-RhoGEF and GEF-H1. Wu RF, Liao C, Fu G, Hayenga HN, Yang K, Ma Z, Liu Z, Terada LS. Mol Cell Biol. 2016 Aug 29. pii: MCB.00194-16. PubMed
BET bromodomain is a novel regulator of TAZ and its activity. Duan Q, Xiao Y, Zhu L, Liu Z, Mao X, Zhou Z, Liao C, Cai J, Huang F, Liu Z, Zeng J, Xia K, Chang C, Qi J, Chen Z, Huang H, Yang T. Biochim Biophys Acta. 2016 Dec;1859(12):1527-1537. doi: 10.1016/j.bbagrm.2016.10.001. Epub 2016 Oct 4. PubMed
A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells. Qu L, Wu Z, Li Y, Xu Z, Liu B, Liu F, Bao Y, Wu D, Liu J, Wang A, Chu X, Sun Y, Chen C, Zhang Z, Wang L. Nat Commun. 2016 Nov 25;7:12692. doi: 10.1038/ncomms12692. PubMed
Inactivation of ABL kinases suppresses non-small cell lung cancer metastasis. Gu JJ, Rouse C, Xu X, Wang J, Onaitis MW, Pendergast AM. JCI Insight. 2016 Dec 22;1(21):e89647. doi: 10.1172/jci.insight.89647. PubMed
DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins. Nguyen HT, Kugler JM, Cohen SM. PLoS One. 2017 Jan 6;12(1):e0169587. doi: 10.1371/journal.pone.0169587. eCollection 2017. PubMed
Systematic morphological profiling of human gene and allele function via Cell Painting. Rohban MH, Singh S, Wu X, Berthet JB, Bray MA, Shrestha Y, Varelas X, Boehm JS, Carpenter AE. Elife. 2017 Mar 18;6. pii: e24060. doi: 10.7554/eLife.24060. PubMed
A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells. Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman SB, Viswanathan P, Logtenberg M, Renz LM, Donati G, Quist SR, Watt FM. Nat Commun. 2017 Mar 23;8:14744. doi: 10.1038/ncomms14744. PubMed
YAP regulates cell mechanics by controlling focal adhesion assembly. Nardone G, Oliver-De La Cruz J, Vrbsky J, Martini C, Pribyl J, Skladal P, Pesl M, Caluori G, Pagliari S, Martino F, Maceckova Z, Hajduch M, Sanz-Garcia A, Pugno NM, Stokin GB, Forte G. Nat Commun. 2017 May 15;8:15321. doi: 10.1038/ncomms15321. PubMed
YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate. Totaro A, Castellan M, Battilana G, Zanconato F, Azzolin L, Giulitti S, Cordenonsi M, Piccolo S. Nat Commun. 2017 May 17;8:15206. doi: 10.1038/ncomms15206. PubMed
Role of TAZ in Lysophosphatidic Acid-Induced Migration and Proliferation of Human Adipose-Derived Mesenchymal Stem Cells. Mo WM, Kwon YW, Jang IH, Choi EJ, Kwon SM, Kim JH. Biomol Ther (Seoul). 2017 Jul 1;25(4):354-361. doi: 10.4062/biomolther.2016.263. PubMed
Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells. Feng J, Yang H, Zhang Y, Wei H, Zhu Z, Zhu B, Yang M, Cao W, Wang L, Wu Z. Oncogene. 2017 Oct 19;36(42):5829-5839. doi: 10.1038/onc.2017.188. Epub 2017 Jun 12. PubMed
Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2. Dieffenbach PB, Haeger CM, Coronata AMF, Choi KM, Varelas X, Tschumperlin DJ, Fredenburgh LE. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L628-L647. doi: 10.1152/ajplung.00173.2017. Epub 2017 Jun 22. PubMed
Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ. Lee WY, Chen PC, Wu WS, Wu HC, Lan CH, Huang YH, Cheng CH, Chen KC, Lin CW. Int J Cancer. 2017 Nov 1;141(9):1921-1931. doi: 10.1002/ijc.30888. Epub 2017 Jul 28. PubMed
Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade. Jia J, Qiao Y, Pilo MG, Cigliano A, Liu X, Shao Z, Calvisi DF, Chen X. PLoS One. 2017 Sep 6;12(9):e0184068. doi: 10.1371/journal.pone.0184068. eCollection 2017. PubMed
USP21 regulates Hippo pathway activity by mediating MARK protein turnover. Nguyen HT, Kugler JM, Loya AC, Cohen SM. Oncotarget. 2017 Jul 18;8(38):64095-64105. doi: 10.18632/oncotarget.19322. eCollection 2017 Sep 8. PubMed
Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells. Ishihara S, Inman DR, Li WJ, Ponik SM, Keely PJ. Cancer Res. 2017 Nov 15;77(22):6179-6189. doi: 10.1158/0008-5472.CAN-17-0569. Epub 2017 Sep 28. PubMed
Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells. Matsudaira T, Mukai K, Noguchi T, Hasegawa J, Hatta T, Iemura SI, Natsume T, Miyamura N, Nishina H, Nakayama J, Semba K, Tomita T, Murata S, Arai H, Taguchi T. Nat Commun. 2017 Nov 1;8(1):1246. doi: 10.1038/s41467-017-01255-3. PubMed
YAP1 is essential for tumor growth and is a potential therapeutic target for EGFR-dependent lung adenocarcinomas. Lee TF, Tseng YC, Chang WC, Chen YC, Kao YR, Chou TY, Ho CC, Wu CW. Oncotarget. 2017 Jul 27;8(52):89539-89551. doi: 10.18632/oncotarget.19647. eCollection 2017 Oct 27. PubMed
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets. Crook ZR, Sevilla GP, Friend D, Brusniak MY, Bandaranayake AD, Clarke M, Gewe M, Mhyre AJ, Baker D, Strong RK, Bradley P, Olson JM. Nat Commun. 2017 Dec 21;8(1):2244. doi: 10.1038/s41467-017-02098-8. PubMed
Enhanced YAP expression leads to EGFR TKI resistance in lung adenocarcinomas. Lee TF, Tseng YC, Nguyen PA, Li YC, Ho CC, Wu CW. Sci Rep. 2018 Jan 10;8(1):271. doi: 10.1038/s41598-017-18527-z. PubMed
Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity. Yuan X, Wei W, Bao Q, Chen H, Jin P, Jiang W. Biomed Pharmacother. 2018 Jun;102:263-270. doi: 10.1016/j.biopha.2018.03.031. Epub 2018 Mar 22. PubMed
Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Xu W, Chen C, Xu R, Li Y, Hu R, Li Z, Zhu X. Biomed Pharmacother. 2018 Jun;102:587-593. doi: 10.1016/j.biopha.2018.03.098. Epub 2018 Apr 5. PubMed
Toward the Discovery of a Novel Class of YAP(-)TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP(-)TEAD Protein(-)Protein Interface. Gibault F, Coevoet M, Sturbaut M, Farce A, Renault N, Allemand F, Guichou JF, Drucbert AS, Foulon C, Magnez R, Thuru X, Corvaisier M, Huet G, Chavatte P, Melnyk P, Bailly F, Cotelle P. Cancers (Basel). 2018 May 8;10(5). pii: cancers10050140. doi: 10.3390/cancers10050140. PubMed
miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP. Choe MH, Yoon Y, Kim J, Hwang SG, Han YH, Kim JS. Cell Death Dis. 2018 May 29;9(6):640. doi: 10.1038/s41419-018-0698-3. PubMed
Tanshinone IIA inhibits cervix carcinoma stem cells migration and invasion via inhibiting YAP transcriptional activity. Qin J, Shi H, Xu Y, Zhao F, Wang Q. Biomed Pharmacother. 2018 Sep;105:758-765. doi: 10.1016/j.biopha.2018.06.028. Epub 2018 Jun 14. PubMed
A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma. Sun J, Wang X, Tang B, Liu H, Zhang M, Wang Y, Ping F, Ding J, Shen A, Geng M. Theranostics. 2018 May 11;8(12):3256-3267. doi: 10.7150/thno.23964. eCollection 2018. PubMed
LncRNA THOR attenuates cisplatin sensitivity of nasopharyngeal carcinoma cells via enhancing cells stemness. Gao L, Cheng XL, Cao H. Biochimie. 2018 Sep;152:63-72. doi: 10.1016/j.biochi.2018.06.015. Epub 2018 Jun 26. PubMed
Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F. Structure. 2018 Aug 7;26(8):1101-1115.e6. doi: 10.1016/j.str.2018.05.014. Epub 2018 Jul 5. PubMed
Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. Nat Commun. 2018 Jul 9;9(1):2372. doi: 10.1038/s41467-018-04590-1. PubMed
Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis. Pavel M, Renna M, Park SJ, Menzies FM, Ricketts T, Fullgrabe J, Ashkenazi A, Frake RA, Lombarte AC, Bento CF, Franze K, Rubinsztein DC. Nat Commun. 2018 Jul 27;9(1):2961. doi: 10.1038/s41467-018-05388-x. PubMed
Cirrhotic stiffness affects the migration of hepatocellular carcinoma cells and induces sorafenib resistance through YAP. Gao J, Rong Y, Huang Y, Shi P, Wang X, Meng X, Dong J, Wu C. J Cell Physiol. 2019 Mar;234(3):2639-2648. doi: 10.1002/jcp.27078. Epub 2018 Aug 26. PubMed
Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone. Gegenfurtner FA, Zisis T, Al Danaf N, Schrimpf W, Kliesmete Z, Ziegenhain C, Enard W, Kazmaier U, Lamb DC, Vollmar AM, Zahler S. Cell Mol Life Sci. 2018 Dec;75(24):4539-4555. doi: 10.1007/s00018-018-2919-4. Epub 2018 Sep 11. PubMed
STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cells. Gao F, Yu X, Meng R, Wang J, Jia L. Onco Targets Ther. 2018 Aug 31;11:5371-5381. doi: 10.2147/OTT.S170775. eCollection 2018. PubMed
Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway. Li J, Wang H, Wang L, Tan R, Zhu M, Zhong X, Zhang Y, Chen B, Wang L. Phytother Res. 2018 Dec;32(12):2456-2465. doi: 10.1002/ptr.6184. Epub 2018 Sep 24. PubMed
Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression. Melhuish TA, Kowalczyk I, Manukyan A, Zhang Y, Shah A, Abounader R, Wotton D. Biochim Biophys Acta Gene Regul Mech. 2018 Nov;1861(11):983-995. doi: 10.1016/j.bbagrm.2018.10.005. Epub 2018 Oct 10. PubMed
The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/beta-Catenin Signaling. Lopez Almeida L, Sebbagh M, Bertucci F, Finetti P, Wicinski J, Marchetto S, Castellano R, Josselin E, Charafe-Jauffret E, Ginestier C, Borg JP, Santoni MJ. Stem Cell Reports. 2018 Nov 13;11(5):1040-1050. doi: 10.1016/j.stemcr.2018.09.008. Epub 2018 Oct 18. PubMed
Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma. Mohamed AD, Shah N, Hettmer S, Vargesson N, Wackerhage H. Sci Rep. 2018 Oct 23;8(1):15674. doi: 10.1038/s41598-018-33852-7. PubMed
TNF-alpha-Induced YAP/TAZ Activity Mediates Leukocyte-Endothelial Adhesion by Regulating VCAM1 Expression in Endothelial Cells. Choi HJ, Kim NE, Kim BM, Seo M, Heo JH. Int J Mol Sci. 2018 Nov 1;19(11). pii: ijms19113428. doi: 10.3390/ijms19113428. PubMed
Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP. Moreno-Vicente R, Pavon DM, Martin-Padura I, Catala-Montoro M, Diez-Sanchez A, Quilez-Alvarez A, Lopez JA, Sanchez-Alvarez M, Vazquez J, Strippoli R, Del Pozo MA. Cell Rep. 2018 Nov 6;25(6):1622-1635.e6. doi: 10.1016/j.celrep.2018.10.024. PubMed
Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity. Li YW, Xu J, Zhu GY, Huang ZJ, Lu Y, Li XQ, Wang N, Zhang FX. Cell Death Discov. 2018 Nov 20;4:105. doi: 10.1038/s41420-018-0124-8. eCollection 2018. PubMed
Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Escot S, Willnow D, Naumann H, Di Francescantonio S, Spagnoli FM. Nat Commun. 2018 Nov 30;9(1):5082. doi: 10.1038/s41467-018-07474-6. PubMed
Luciferase Reporter Assays to Determine YAP/TAZ Activity in Mammalian Cells. Dupont S. Methods Mol Biol. 2019;1893:121-135. doi: 10.1007/978-1-4939-8910-2_11. PubMed
Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts. Ferrari N, Ranftl R, Chicherova I, Slaven ND, Moeendarbary E, Farrugia AJ, Lam M, Semiannikova M, Westergaard MCW, Tchou J, Magnani L, Calvo F. Nat Commun. 2019 Jan 10;10(1):130. doi: 10.1038/s41467-018-07987-0. PubMed
Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking. Smith SA, Sessions RB, Shoemark DK, Williams C, Ebrahimighaei R, McNeill MC, Crump MP, McKay TR, Harris G, Newby AC, Bond M. J Med Chem. 2019 Feb 14;62(3):1291-1305. doi: 10.1021/acs.jmedchem.8b01402. Epub 2019 Jan 31. PubMed
TRAF6 regulates YAP signaling by promoting the ubiquitination and degradation of MST1 in pancreatic cancer. Li JA, Kuang T, Pu N, Fang Y, Han X, Zhang L, Xu X, Wu W, Wang D, Lou W, Rong Y. Clin Exp Med. 2019 May;19(2):211-218. doi: 10.1007/s10238-018-00543-6. Epub 2019 Jan 23. PubMed
Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP. Romani P, Brian I, Santinon G, Pocaterra A, Audano M, Pedretti S, Mathieu S, Forcato M, Bicciato S, Manneville JB, Mitro N, Dupont S. Nat Cell Biol. 2019 Mar;21(3):338-347. doi: 10.1038/s41556-018-0270-5. Epub 2019 Feb 4. PubMed

Associated Plasmids

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, Konig GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS. Cancer Cell. 2019 Mar 18;35(3):457-472.e5. doi: 10.1016/j.ccell.2019.01.009. Epub 2019 Feb 14. PubMed
MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis. Cui J, Zhou Z, Yang H, Jiao F, Li N, Gao Y, Wang L, Chen J, Quan M. Mol Cancer Res. 2019 Jun;17(6):1316-1325. doi: 10.1158/1541-7786.MCR-18-0910. Epub 2019 Feb 22. PubMed
SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma. Isfort I, Cyra M, Elges S, Kailayangiri S, Altvater B, Rossig C, Steinestel K, Grunewald I, Huss S, Esseling E, Mikesch JH, Hafner S, Simmet T, Wozniak A, Schoffski P, Larsson O, Wardelmann E, Trautmann M, Hartmann W. Clin Cancer Res. 2019 Jun 15;25(12):3718-3731. doi: 10.1158/1078-0432.CCR-17-3553. Epub 2019 Feb 27. PubMed
miR-7977 inhibits the Hippo-YAP signaling pathway in bone marrow mesenchymal stromal cells. Yoshida M, Horiguchi H, Kikuchi S, Iyama S, Ikeda H, Goto A, Kawano Y, Murase K, Takada K, Miyanishi K, Kato J, Kobune M. PLoS One. 2019 Mar 5;14(3):e0213220. doi: 10.1371/journal.pone.0213220. eCollection 2019. PubMed
Lovastatin attenuates angiotensin II induced cardiovascular fibrosis through the suppression of YAP/TAZ signaling. Wu P, Liu Z, Zhao T, Xia F, Gong L, Zheng Z, Chen Z, Yang T, Duan Q. Biochem Biophys Res Commun. 2019 May 14;512(4):736-741. doi: 10.1016/j.bbrc.2019.03.158. Epub 2019 Mar 27. PubMed
Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J, Tang F, Liu GH. PLoS Biol. 2019 Apr 1;17(4):e3000201. doi: 10.1371/journal.pbio.3000201. eCollection 2019 Apr. PubMed
The mevalonate coordinates energy input and cell proliferation. Gong L, Xiao Y, Xia F, Wu P, Zhao T, Xie S, Wang R, Wen Q, Zhou W, Xu H, Zhu L, Zheng Z, Yang T, Chen Z, Duan Q. Cell Death Dis. 2019 Apr 11;10(4):327. doi: 10.1038/s41419-019-1544-y. PubMed
A RASSF1A-HIF1alpha loop drives Warburg effect in cancer and pulmonary hypertension. Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS. Nat Commun. 2019 May 13;10(1):2130. doi: 10.1038/s41467-019-10044-z. PubMed
FRMPD1 activates the Hippo pathway via interaction with WWC3 to suppress the proliferation and invasiveness of lung cancer cells. Rong X, Han Q, Lin X, Kremerskothen J, Wang E. Cancer Manag Res. 2019 Apr 18;11:3395-3410. doi: 10.2147/CMAR.S194512. eCollection 2019. PubMed
Long noncoding RNA MALAT1 promotes the stemness of esophageal squamous cell carcinoma by enhancing YAP transcriptional activity. Yao Q, Yang J, Liu T, Zhang J, Zheng Y. FEBS Open Bio. 2019 Aug;9(8):1392-1402. doi: 10.1002/2211-5463.12676. Epub 2019 Jun 11. PubMed
Metastatic Colorectal Cancer Rewrites Metabolic Program Through a Glut3-YAP-dependent Signaling Circuit. Kuo CC, Ling HH, Chiang MC, Chung CH, Lee WY, Chu CY, Wu YC, Chen CH, Lai YW, Tsai IL, Cheng CH, Lin CW. Theranostics. 2019 Apr 13;9(9):2526-2540. doi: 10.7150/thno.32915. eCollection 2019. PubMed
Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation. Torrini C, Cubero RJ, Dirkx E, Braga L, Ali H, Prosdocimo G, Gutierrez MI, Collesi C, Licastro D, Zentilin L, Mano M, Zacchigna S, Vendruscolo M, Marsili M, Samal A, Giacca M. Cell Rep. 2019 May 28;27(9):2759-2771.e5. doi: 10.1016/j.celrep.2019.05.005. PubMed
YAP mediates the positive regulation of hnRNPK on the lung adenocarcinoma H1299 cell growth. Xu L, Zhang T, Huang W, Liu X, Lu J, Gao X, Zhang YF, Liu L. Acta Biochim Biophys Sin (Shanghai). 2019 Jul 10;51(7):677-687. doi: 10.1093/abbs/gmz053. PubMed
HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma. Faiao-Flores F, Emmons MF, Durante MA, Kinose F, Saha B, Fang B, Koomen JM, Chellappan SP, Maria-Engler SS, Rix U, Licht JD, Harbour JW, Smalley KSM. Clin Cancer Res. 2019 Jun 21. pii: 1078-0432.CCR-18-3382. doi: 10.1158/1078-0432.CCR-18-3382. PubMed
Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance Induced by Membranous/Cytoplasmic/Nuclear Translocation of Epidermal Growth Factor Receptor. Rong X, Liang Y, Han Q, Zhao Y, Jiang G, Zhang X, Lin X, Liu Y, Zhang Y, Han X, Zhang M, Luo Y, Li P, Wei L, Yan T, Wang E. J Thorac Oncol. 2019 Jun 19. pii: S1556-0864(19)30480-0. doi: 10.1016/j.jtho.2019.06.014. PubMed
YAP promotes neural crest emigration through interactions with BMP and Wnt activities. Kumar D, Nitzan E, Kalcheim C. Cell Commun Signal. 2019 Jun 22;17(1):69. doi: 10.1186/s12964-019-0383-x. PubMed
The protein secretion modulator TMED9 drives CNIH4/TGFalpha/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases. Mishra S, Bernal C, Silvano M, Anand S, Ruiz I Altaba A. Oncogene. 2019 Jul;38(29):5817-5837. doi: 10.1038/s41388-019-0845-z. Epub 2019 Jun 28. PubMed
Elevated cyclic-AMP represses expression of exchange protein activated by cAMP (EPAC1) by inhibiting YAP-TEAD activity and HDAC-mediated histone deacetylation. Ebrahimighaei R, McNeill MC, Smith SA, Wray JP, Ford KL, Newby AC, Bond M. Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1634-1649. doi: 10.1016/j.bbamcr.2019.06.013. Epub 2019 Jun 28. PubMed
YAP-Induced Endothelial-Mesenchymal Transition in Oral Submucous Fibrosis. Li J, Yao M, Zhu X, Li Q, He J, Chen L, Wang W, Zhu C, Shen T, Cao R, Fang C. J Dent Res. 2019 Jul;98(8):920-929. doi: 10.1177/0022034519851804. PubMed
Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, Chen ZN, Jiang X. Nature. 2019 Aug;572(7769):402-406. doi: 10.1038/s41586-019-1426-6. Epub 2019 Jul 24. PubMed
Nuclear envelope deformation controls cell cycle progression in response to mechanical force. Aureille J, Buffiere-Ribot V, Harvey BE, Boyault C, Pernet L, Andersen T, Bacola G, Balland M, Fraboulet S, Van Landeghem L, Guilluy C. EMBO Rep. 2019 Sep;20(9):e48084. doi: 10.15252/embr.201948084. Epub 2019 Aug 1. PubMed
Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer. Sethunath V, Hu H, De Angelis C, Veeraraghavan J, Qin L, Wang N, Simon LM, Wang T, Fu X, Nardone A, Pereira R, Nanda S, Griffith OL, Tsimelzon A, Shaw C, Chamness GC, Reis-Filho JS, Weigelt B, Heiser LM, Hilsenbeck SG, Huang S, Rimawi MF, Gray JW, Osborne CK, Schiff R. Mol Cancer Res. 2019 Nov;17(11):2318-2330. doi: 10.1158/1541-7786.MCR-19-0756. Epub 2019 Aug 16. PubMed
Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction. Costa R, Peruzzo R, Bachmann M, Monta GD, Vicario M, Santinon G, Mattarei A, Moro E, Quintana-Cabrera R, Scorrano L, Zeviani M, Vallese F, Zoratti M, Paradisi C, Argenton F, Brini M, Cali T, Dupont S, Szabo I, Leanza L. Cell Rep. 2019 Aug 20;28(8):1949-1960.e6. doi: 10.1016/j.celrep.2019.07.050. PubMed
Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells. Giraud J, Molina-Castro S, Seeneevassen L, Sifre E, Izotte J, Tiffon C, Staedel C, Boeuf H, Fernandez S, Barthelemy P, Megraud F, Lehours P, Dubus P, Varon C. Int J Cancer. 2020 Apr 15;146(8):2255-2267. doi: 10.1002/ijc.32667. Epub 2019 Sep 30. PubMed
Insulin suppresses transcriptional activity of yes-associated protein in insulin target cells. Sayedyahossein S, Hedman AC, Sacks DB. Mol Biol Cell. 2020 Jan 15;31(2):131-141. doi: 10.1091/mbc.E19-04-0205. Epub 2019 Nov 6. PubMed
DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression. Jimenez-Martinez M, Ostale CM, van der Burg LR, Galan-Martinez J, Hardwick JCH, Lopez-Perez R, Hawinkels LJAC, Stamatakis K, Fresno M. Cancers (Basel). 2019 Nov 9;11(11). pii: cancers11111767. doi: 10.3390/cancers11111767. PubMed
YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression. Li H, Li Q, Dang K, Ma S, Cotton JL, Yang S, Zhu LJ, Deng AC, Ip YT, Johnson RL, Wu X, Punzo C, Mao J. Cell Rep. 2019 Dec 3;29(10):3200-3211.e4. doi: 10.1016/j.celrep.2019.03.021. PubMed
Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-beta. Yin X, Choudhury M, Kang JH, Schaefbauer KJ, Jung MY, Andrianifahanana M, Hernandez DM, Leof EB. Sci Signal. 2019 Dec 17;12(612). pii: 12/612/eaax4067. doi: 10.1126/scisignal.aax4067. PubMed
Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone. Isfort I, Elges S, Cyra M, Berthold R, Renner M, Mechtersheimer G, Aman P, Larsson O, Ratner N, Hafner S, Simmet T, Schliemann C, Rossig C, Dirksen U, Grunewald I, Wardelmann E, Huss S, Hartmann W, Trautmann M. Sci Rep. 2019 Dec 23;9(1):19704. doi: 10.1038/s41598-019-56247-8. PubMed
Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma. Rodriguez-Nunez P, Romero-Perez L, Amaral AT, Puerto-Camacho P, Jordan C, Marcilla D, Grunewald TG, Alonso J, de Alava E, Diaz-Martin J. J Pathol. 2020 Apr;250(4):374-386. doi: 10.1002/path.5379. Epub 2020 Feb 4. PubMed
Dynein-mediated nuclear translocation of yes-associated protein through microtubule acetylation controls fibroblast activation. You E, Ko P, Jeong J, Keum S, Kim JW, Seo YJ, Song WK, Rhee S. Cell Mol Life Sci. 2020 Jan 7. pii: 10.1007/s00018-019-03412-x. doi: 10.1007/s00018-019-03412-x. PubMed
YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H. Nat Commun. 2020 Jan 24;11(1):507. doi: 10.1038/s41467-020-14353-6. PubMed
Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP. Irie K, Nagai T, Mizuno K. J Biol Chem. 2020 Mar 6;295(10):3017-3028. doi: 10.1074/jbc.RA119.010783. Epub 2020 Jan 29. PubMed
RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1. Nguyen TH, Ralbovska A, Kugler JM. G3 (Bethesda). 2020 Apr 9;10(4):1319-1325. doi: 10.1534/g3.120.401038. PubMed
Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD. McNeill MC, Wray J, Sala-Newby GB, Hindmarch CCT, Smith SA, Ebrahimighaei R, Newby AC, Bond M. Biochim Biophys Acta Mol Cell Res. 2020 Jul;1867(7):118691. doi: 10.1016/j.bbamcr.2020.118691. Epub 2020 Feb 28. PubMed
Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-catenin. Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, Zhang X, Zhou Y, Yadav PS, Lin J, Wu N, Zhao L, Huang D, Zhou S, Su P, Yang Y. Elife. 2020 Mar 18;9. pii: 52779. doi: 10.7554/eLife.52779. PubMed
YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity. Yuan Y, Park J, Feng A, Awasthi P, Wang Z, Chen Q, Iglesias-Bartolome R. Nat Commun. 2020 Mar 19;11(1):1472. doi: 10.1038/s41467-020-15301-0. PubMed
FOXM1 facilitates breast cancer cell stemness and migration in YAP1-dependent manner. Sun HL, Men JR, Liu HY, Liu MY, Zhang HS. Arch Biochem Biophys. 2020 May 30;685:108349. doi: 10.1016/j.abb.2020.108349. Epub 2020 Mar 21. PubMed
The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy. Guo Q, Quan M, Dong J, Bai J, Wang J, Han R, Wang W, Cai Y, Lv YQ, Chen Q, Xu H, Lyu HD, Deng L, Zhou D, Xiao X, De Langhe S, Billadeau DD, Lou Z, Zhang JS. Theranostics. 2020 Mar 15;10(10):4422-4436. doi: 10.7150/thno.42795. eCollection 2020. PubMed
IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Rigiracciolo DC, Nohata N, Lappano R, Cirillo F, Talia M, Scordamaglia D, Gutkind JS, Maggiolini M. Cells. 2020 Apr 18;9(4). pii: cells9041010. doi: 10.3390/cells9041010. PubMed
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Waaler J, Mygland L, Tveita A, Strand MF, Solberg NT, Olsen PA, Aizenshtadt A, Fauskanger M, Lund K, Brinch SA, Lycke M, Dybing E, Nygaard V, Boe SL, Heintz KM, Hovig E, Hammarstrom C, Corthay A, Krauss S. Commun Biol. 2020 Apr 24;3(1):196. doi: 10.1038/s42003-020-0916-2. PubMed
The Long Non-Coding RNA MALAT1 Enhances Ovarian Cancer Cell Stemness by Inhibiting YAP Translocation from Nucleus to Cytoplasm. Wu X, Wang Y, Zhong W, Cheng H, Tian Z. Med Sci Monit. 2020 May 20;26:e922012. doi: 10.12659/MSM.922012. PubMed
Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta. Meinhardt G, Haider S, Kunihs V, Saleh L, Pollheimer J, Fiala C, Hetey S, Feher Z, Szilagyi A, Than NG, Knofler M. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13562-13570. doi: 10.1073/pnas.2002630117. Epub 2020 Jun 1. PubMed
Luteolin suppresses epithelial-mesenchymal transition and migration of triple-negative breast cancer cells by inhibiting YAP/TAZ activity. Cao D, Zhu GY, Lu Y, Yang A, Chen D, Huang HJ, Peng SX, Chen LW, Li YW. Biomed Pharmacother. 2020 Sep;129:110462. doi: 10.1016/j.biopha.2020.110462. Epub 2020 Jul 6. PubMed
RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer. Yang H, Hu J, Chen J, Chen Z, Jiao F, Cui J, Quan M, Wang L. Med Oncol. 2020 Aug 11;37(9):84. doi: 10.1007/s12032-020-01384-8. PubMed
VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. Lorenzo-Martin LF, Fernandez-Parejo N, Menacho-Marquez M, Rodriguez-Fdez S, Robles-Valero J, Zumalave S, Fabbiano S, Pascual G, Garcia-Pedrero JM, Abad A, Garcia-Macias MC, Gonzalez N, Lorenzano-Menna P, Pavon MA, Gonzalez-Sarmiento R, Segrelles C, Paramio JM, Tubio JMC, Rodrigo JP, Benitah SA, Cuadrado M, Bustelo XR. Nat Commun. 2020 Sep 22;11(1):4788. doi: 10.1038/s41467-020-18524-3. PubMed
Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/beta-Catenin Signaling. Li Y, Chen M, Hu J, Sheng R, Lin Q, He X, Guo M. Cell Stem Cell. 2021 Jan 7;28(1):63-78.e7. doi: 10.1016/j.stem.2020.09.012. Epub 2020 Oct 13. PubMed
PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin. Wei L, Li P, Luo Y, Zhang M, Yan T, Yang Y, Han Y, Liu S, Wang E. Onco Targets Ther. 2020 Oct 8;13:10025-10037. doi: 10.2147/OTT.S263815. eCollection 2020. PubMed
PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells. Bruschi FV, Tardelli M, Einwallner E, Claudel T, Trauner M. Int J Mol Sci. 2020 Nov 18;21(22). pii: ijms21228711. doi: 10.3390/ijms21228711. PubMed
Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis. Kim J, Kang W, Kang SH, Park SH, Kim JY, Yang S, Ha SY, Paik YH. Sci Rep. 2020 Dec 3;10(1):21018. doi: 10.1038/s41598-020-78056-0. PubMed
Crosstalk between YAP and TGFbeta regulates SERPINE1 expression in mesenchymal lung cancer cells. Kong HJ, Kwon EJ, Kwon OS, Lee H, Choi JY, Kim YJ, Kim W, Cha HJ. Int J Oncol. 2021 Jan;58(1):111-121. doi: 10.3892/ijo.2020.5153. Epub 2020 Nov 27. PubMed
The YAP/TEAD Axis as a New Therapeutic Target in Osteosarcoma: Effect of Verteporfin and CA3 on Primary Tumor Growth. Morice S, Mullard M, Brion R, Dupuy M, Renault S, Tesfaye R, Brounais-Le Royer B, Ory B, Redini F, Verrecchia F. Cancers (Basel). 2020 Dec 20;12(12). pii: cancers12123847. doi: 10.3390/cancers12123847. PubMed
Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling. Delgado ER, Erickson HL, Tao J, Monga SP, Duncan AW, Anakk S. Mol Cell Biol. 2021 Mar 24;41(4). pii: MCB.00596-20. doi: 10.1128/MCB.00596-20. Print 2021 Mar 24. PubMed
A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells. Dai Y, Kyoyama H, Yang YL, Wang Y, Liu S, Wang Y, Mao JH, Xu Z, Uematsu K, Jablons DM, You L. Oncotarget. 2021 Feb 2;12(3):173-184. doi: 10.18632/oncotarget.27871. eCollection 2021 Feb 2. PubMed
Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, Otani Y, Tomita Y, Hattori Y, Matsumoto Y, Tsuboi N, Makino K, Hirano S, Kamiya A, Date I. Acta Neuropathol Commun. 2021 Feb 22;9(1):29. doi: 10.1186/s40478-021-01124-7. PubMed
IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway. Quinn NP, Garcia-Gutierrez L, Doherty C, von Kriegsheim A, Fallahi E, Sacks DB, Matallanas D. Cells. 2021 Feb 23;10(2). pii: cells10020478. doi: 10.3390/cells10020478. PubMed
Evidence for discrete modes of YAP1 signaling via mRNA splice isoforms in development and diseases. Vrbsky J, Vinarsky V, Perestrelo AR, De La Cruz JO, Martino F, Pompeiano A, Izzi V, Hlinomaz O, Rotrekl V, Sudol M, Pagliari S, Forte G. Genomics. 2021 May;113(3):1349-1365. doi: 10.1016/j.ygeno.2021.03.009. Epub 2021 Mar 11. PubMed
alpha-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation. Pavel M, Park SJ, Frake RA, Son SM, Manni MM, Bento CF, Renna M, Ricketts T, Menzies FM, Tanasa R, Rubinsztein DC. Nat Commun. 2021 Mar 17;12(1):1703. doi: 10.1038/s41467-021-21882-1. PubMed
Critical role of the BAF chromatin remodeling complex during murine neural crest development. Bi-Lin KW, Seshachalam PV, Tuoc T, Stoykova A, Ghosh S, Singh MK. PLoS Genet. 2021 Mar 22;17(3):e1009446. doi: 10.1371/journal.pgen.1009446. eCollection 2021 Mar. PubMed
WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression. Han Q, Rong X, Lin X, Zhang X, Fan C, Zhao H, Wang E. Cell Death Dis. 2021 Apr 9;12(4):384. doi: 10.1038/s41419-021-03600-3. PubMed
Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris. Huang Y, Jedlickova H, Cai Y, Rehman A, Gammon L, Ahmad US, Uttagomol J, Parkinson EK, Fortune F, Wan H. Front Immunol. 2021 Apr 19;12:649502. doi: 10.3389/fimmu.2021.649502. eCollection 2021. PubMed
VGLL4 inhibits YAP1/TEAD signaling to suppress the epidermal squamous cell carcinoma cancer phenotype. Mickle M, Adhikary G, Shrestha S, Xu W, Eckert RL. Mol Carcinog. 2021 Jul;60(7):497-507. doi: 10.1002/mc.23307. Epub 2021 May 18. PubMed
YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior. Jeon Y, Yoo JE, Rhee H, Kim YJ, Il Kim G, Chung T, Yoon S, Shin B, Woo HG, Park YN. Exp Mol Med. 2021 Jun;53(6):1055-1067. doi: 10.1038/s12276-021-00639-2. Epub 2021 Jun 18. PubMed
Single-Component Optogenetic Tools for Inducible RhoA GTPase Signaling. Berlew EE, Kuznetsov IA, Yamada K, Bugaj LJ, Boerckel JD, Chow BY. Adv Biol (Weinh). 2021 Sep;5(9):e2100810. doi: 10.1002/adbi.202100810. Epub 2021 Jul 21. PubMed
Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. Mygland L, Brinch SA, Strand MF, Olsen PA, Aizenshtadt A, Lund K, Solberg NT, Lycke M, Thorvaldsen TE, Espada S, Misaghian D, Page CM, Agafonov O, Nygard S, Chi NW, Lin E, Tan J, Yu Y, Costa M, Krauss S, Waaler J. iScience. 2021 Jul 1;24(7):102807. doi: 10.1016/j.isci.2021.102807. eCollection 2021 Jul 23. PubMed
KCTD11 inhibits progression of lung cancer by binding to beta-catenin to regulate the activity of the Wnt and Hippo pathways. Yang M, Han YM, Han Q, Rong XZ, Liu XF, Ln XY. J Cell Mol Med. 2021 Oct;25(19):9411-9426. doi: 10.1111/jcmm.16883. Epub 2021 Aug 28. PubMed
LncRNA coordinates Hippo and mTORC1 pathway activation in cancer. Zhang S, Liang S, Wu D, Guo H, Ma K, Liu L. Cell Death Dis. 2021 Aug 30;12(9):822. doi: 10.1038/s41419-021-04112-w. PubMed
Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation. Sun B, Zhong FJ, Xu C, Li YM, Zhao YR, Cao MM, Yang LY. Cell Death Dis. 2021 Sep 14;12(9):849. doi: 10.1038/s41419-021-04139-z. PubMed
TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states. Xu S, Liu Y, Hu R, Wang M, Stohr O, Xiong Y, Chen L, Kang H, Zheng L, Cai S, He L, Wang C, Copps KD, White MF, Miao J. Elife. 2021 Oct 8;10. pii: 57462. doi: 10.7554/eLife.57462. PubMed
Involvement of the TGF-beta Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis. Morice S, Danieau G, Tesfaye R, Mullard M, Brion R, Dupuy M, Ory B, Brounais-Le Royer B, Corre I, Redini F, Verrecchia F. Front Oncol. 2021 Oct 26;11:765711. doi: 10.3389/fonc.2021.765711. eCollection 2021. PubMed

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