pcDNA3-FLAG-HA-CAD Citations (3)

Originally described in: Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
Ben-Sahra I, Howell JJ, Asara JM, Manning BD Science. 2013 Mar 15;339(6125):1323-8. doi: 10.1126/science.1228792. Epub 2013 Feb 21. PubMed Journal

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Articles Citing pcDNA3-FLAG-HA-CAD

Articles
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence. Yang C, Zhao Y, Wang L, Guo Z, Ma L, Yang R, Wu Y, Li X, Niu J, Chu Q, Fu Y, Li B. Nat Cell Biol. 2023 Jun;25(6):836-847. doi: 10.1038/s41556-023-01146-4. Epub 2023 Jun 8. PubMed
PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth. Da Q, Cai Y, Ma Q, Yang Q, Cao Y, Zhou Y, Zhao D, Liu Z, Xu J, Quan J, Zhang L, Wang R, Jiang X, Liu X, Ouyang K, Han Z, Liu J, Wang T, Zhang C, Weintraub NL, Fulton DJR, Zhao J, Hong M, Li Z, Huo Y. Cell Rep. 2025 Aug 26;44(8):116071. doi: 10.1016/j.celrep.2025.116071. Epub 2025 Jul 29. PubMed
HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis. Ikeda T, Hong S, Yoshida S, Srivastava SP, Kunamneni A, Yao Y, Khuperkar O, Basrur V, Kuang H, Kachman M, Raskind A, Baum H, Joshi A, Swaroop V, Thurman A, Kopasz-Gemmen O, Kandukuri S, Pradeepa FNU, Yonekura H, Lin JD, Inoki K. Cell Rep. 2025 Oct 28;44(10):116382. doi: 10.1016/j.celrep.2025.116382. Epub 2025 Oct 10. PubMed

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