Mouse Brie kinome pooled library, guides 1-4 in lentiGuide-Puro backbone Citations (6)

Originally described in: Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.
Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE Nat Biotechnol. 2016 Jan 18. doi: 10.1038/nbt.3437. PubMed Journal

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Articles Citing Mouse Brie kinome pooled library, guides 1-4 in lentiGuide-Puro backbone

Articles
Next-Generation Sequencing of Genome-Wide CRISPR Screens. Yau EH, Rana TM. Methods Mol Biol. 2018;1712:203-216. doi: 10.1007/978-1-4939-7514-3_13. PubMed
Pooled Lentiviral-Delivery Genetic Screens. Piccioni F, Younger ST, Root DE. Curr Protoc Mol Biol. 2018 Jan 16;121:32.1.1-32.1.21. doi: 10.1002/cpmb.52. PubMed
CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Lan B, Zeng S, Zhang S, Ren X, Xing Y, Kutschick I, Pfeffer S, Frey B, Britzen-Laurent N, Grutzmann R, Cordes N, Pilarsky C. Cancers (Basel). 2022 Jan 10;14(2). pii: cancers14020326. doi: 10.3390/cancers14020326. PubMed
Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma. Pandey GK, Landman N, Neikes HK, Hulsman D, Lieftink C, Beijersbergen R, Kolluri KK, Janes SM, Vermeulen M, Badhai J, van Lohuizen M. Cell Rep Med. 2023 Feb 21;4(2):100915. doi: 10.1016/j.xcrm.2022.100915. Epub 2023 Jan 18. PubMed
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Rogava M, Aprati TJ, Chi WY, Melms JC, Hug C, Davis SH, Earlie EM, Chung C, Deshmukh SK, Wu S, Sledge G, Tang S, Ho P, Amin AD, Caprio L, Gurjao C, Tagore S, Ngo B, Lee MJ, Zanetti G, Wang Y, Chen S, Ge W, Melo LMN, Allies G, Rosler J, Gibney GT, Schmitz OJ, Sykes M, Creusot RJ, Tuting T, Schadendorf D, Rocken M, Eigentler TK, Molotkov A, Mintz A, Bakhoum SF, Beyaz S, Cantley LC, Sorger PK, Meckelmann SW, Tasdogan A, Liu D, Laughney AM, Izar B. Nat Cancer. 2024 Mar;5(3):433-447. doi: 10.1038/s43018-023-00704-x. Epub 2024 Jan 29. PubMed
Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Zhang S, Yun D, Yang H, Eckstein M, Elbait GD, Zhou Y, Lu Y, Yang H, Zhang J, Dorflein I, Britzen-Laurent N, Pfeffer S, Stemmler MP, Dahl A, Mukhopadhyay D, Chang D, He H, Zeng S, Lan B, Frey B, Hampel C, Lentsch E, Gollavilli PN, Buttner C, Ekici AB, Biankin A, Schneider-Stock R, Ceppi P, Grutzmann R, Pilarsky C. Cell Death Discov. 2024 Mar 9;10(1):124. doi: 10.1038/s41420-024-01890-y. PubMed

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