pLV-U6-gRNA-UbC-DsRed-P2A-Bsr Citations (10)
Originally described in: CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.Klann TS, Black JB, Chellappan M, Safi A, Song L, Hilton IB, Crawford GE, Reddy TE, Gersbach CA Nat Biotechnol. 2017 Apr 3. doi: 10.1038/nbt.3853. PubMed Journal
Articles Citing pLV-U6-gRNA-UbC-DsRed-P2A-Bsr
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| Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing. Klann TS, Crawford GE, Reddy TE, Gersbach CA. Methods Mol Biol. 2018;1767:447-480. doi: 10.1007/978-1-4939-7774-1_25. PubMed |
| Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma. Bayles I, Krajewska M, Pontius WD, Saiakhova A, Morrow JJ, Bartels C, Lu J, Faber ZJ, Fedorov Y, Hong ES, Karnuta JM, Rubin B, Adams DJ, George RE, Scacheri PC. J Clin Invest. 2019 Oct 1;129(10):4377-4392. doi: 10.1172/JCI127718. PubMed |
| Synergistic CRISPRa-Regulated Chondrogenic Extracellular Matrix Deposition Without Exogenous Growth Factors. Farhang N, Davis B, Weston J, Ginley-Hidinger M, Gertz J, Bowles RD. Tissue Eng Part A. 2020 Nov;26(21-22):1169-1179. doi: 10.1089/ten.TEA.2020.0062. Epub 2020 Jul 9. PubMed |
| Endogenous retroviruses drive species-specific germline transcriptomes in mammals. Sakashita A, Maezawa S, Takahashi K, Alavattam KG, Yukawa M, Hu YC, Kojima S, Parrish NF, Barski A, Pavlicev M, Namekawa SH. Nat Struct Mol Biol. 2020 Oct;27(10):967-977. doi: 10.1038/s41594-020-0487-4. Epub 2020 Sep 7. PubMed |
| Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation and is altered with age. Maybury-Lewis SY, Brown AK, Yeary M, Sloutskin A, Dhakal S, Juven-Gershon T, Webb AE. Aging Cell. 2021 Nov;20(11):e13499. doi: 10.1111/acel.13499. Epub 2021 Oct 23. PubMed |
| Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure. Bohnsack JP, Zhang H, Wandling GM, He D, Kyzar EJ, Lasek AW, Pandey SC. Sci Adv. 2022 May 6;8(18):eabn2748. doi: 10.1126/sciadv.abn2748. Epub 2022 May 4. PubMed |
| A Therapeutically Targetable NOTCH1-SIRT1-KAT7 Axis in T-cell Leukemia. Lancho O, Singh A, da Silva-Diz V, Aleksandrova M, Khatun J, Tottone L, Nunes PR, Luo S, Zhao C, Zheng H, Chiles E, Zuo Z, Rocha PP, Su X, Khiabanian H, Herranz D. Blood Cancer Discov. 2023 Jan 6;4(1):12-33. doi: 10.1158/2643-3230.BCD-22-0098. PubMed |
| Multiplex gene editing to promote cell survival using low-pH clustered regularly interspaced short palindromic repeats activation (CRISPRa) gene perturbation. Levis H, Weston J, Austin B, Larsen B, Ginley-Hidinger M, Gullbrand SE, Lawrence B, Bowles RD. Cytotherapy. 2023 May 27:S1465-3249(23)00932-5. doi: 10.1016/j.jcyt.2023.05.001. PubMed |
| Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization. Cerda-Smith CG, Hutchinson HM, Liu A, Goel VY, Sept C, Kim H, Casani-Galdon S, Burkman KG, Bassil CF, Hansen AS, Aryee MJ, Johnstone SE, Eyler CE, Wood KC. bioRxiv [Preprint]. 2023 Sep 21:2023.09.20.558459. doi: 10.1101/2023.09.20.558459. PubMed |
| Temporal chromatin accessibility changes define transcriptional states essential for osteosarcoma metastasis. Pontius WD, Hong ES, Faber ZJ, Gray J, Peacock CD, Bayles I, Lovrenert K, Chin DH, Gryder BE, Bartels CF, Scacheri PC. Nat Commun. 2023 Nov 8;14(1):7209. doi: 10.1038/s41467-023-42656-x. PubMed |
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