hCRISPRi-v2, Kinases, Phosphatases, and Drug Targets (h1), top 5 sgRNAs/gene Citations (4)

Originally described in: Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.
Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS Elife. 2016 Sep 23;5. pii: e19760. doi: 10.7554/eLife.19760. PubMed Journal

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Articles Citing hCRISPRi-v2, Kinases, Phosphatases, and Drug Targets (h1), top 5 sgRNAs/gene

Articles
Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2. O'Leary PC, Chen H, Doruk YU, Williamson T, Polacco B, McNeal AS, Shenoy T, Kale N, Carnevale J, Stevenson E, Quigley DA, Chou J, Feng FY, Swaney DL, Krogan NJ, Kim M, Diolaiti ME, Ashworth A. Cancer Res. 2022 Nov 2;82(21):3950-3961. doi: 10.1158/0008-5472.CAN-21-4335. PubMed
Ribosome rescue factor PELOTA modulates translation start site choice and protein isoform levels of transcription factor C/EBPalpha. Fernandez SG, Ferguson L, Ingolia NT. bioRxiv. 2023 Jan 17:2023.01.16.524343. doi: 10.1101/2023.01.16.524343. Preprint. PubMed
CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity. Liu C, Shen M, Liu Y, Manhas A, Zhao SR, Zhang M, Belbachir N, Ren L, Zhang JZ, Caudal A, Nishiga M, Thomas D, Zhang A, Yang H, Zhou Y, Ameen M, Sayed N, Rhee JW, Qi LS, Wu JC. Cell Stem Cell. 2024 Dec 5;31(12):1760-1776.e9. doi: 10.1016/j.stem.2024.10.007. Epub 2024 Nov 7. PubMed
Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer. Cordova RA, Sommers NR, Law AS, Klunk AJ, Brady KE, Goodrich DW, Anthony TG, Brault JJ, Pili R, Wek RC, Staschke KA. Sci Signal. 2024 Nov 26;17(864):eadp1375. doi: 10.1126/scisignal.adp1375. Epub 2024 Nov 26. PubMed

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